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Antibody against poly(ethylene glycol) adversely affects PEG‐asparaginase therapy in acute lymphoblastic leukemia patients
The objective of the study was to determine whether anti‐PEG was associated with rapid clearance PEG‐ASNase, and if so, how prevalent it was in healthy blood donors.
Association of busulfan exposure with survival and toxicity after haemopoietic cell transplantation in children and young adults: a multicentre, retrospective cohort analysis.
Pharmacokinetics of linezolid in septic patients with and without extended dialysis
- S. Swoboda, M. Ober, M. Weigand
- Medicine, BiologyEuropean Journal of Clinical Pharmacology
- 1 March 2010
The results suggest that linezolid pharmacokinetics in critically ill patients with ARF undergoing ED is not comparable to that in healthy subjects and patients without ARF, and the best method of managing lineZolid dosage in such a complex group of patients, whose physiology can vary daily, would be to use therapeutic drug monitoring.
Body Weight-Dependent Pharmacokinetics of Busulfan in Paediatric Haematopoietic Stem Cell Transplantation Patients
The model-based individual dosing nomogram is expected to result in predictive busulfan exposures in patients ranging between 3 and 65 kg and thereby to a safer and more effective conditioning regimen for HSCT in children.
Preparative and analytical separation of the zopiclone enantiomers and determination of their affinity to the benzodiazepine receptor binding site.
The preparative separation of rac-zopiclone using malic acid as the resolving agent and benzodiazepine receptor binding of the isolated enantiomers was investigated, indicating a more than 50 times higher affinity of the (+)-enantiomer toward the receptor.
The effect of cyclophosphamide on the immune system: implications for clinical cancer therapy
Of special interest is the fact that a single administration of low-dose cyclophosphamide is able to selectively suppress regulatory T cells (Tregs) and can be used to counteract immunosuppression in cancer.
Population Pharmacokinetics of Amphotericin B Lipid Complex in Neonates
- G. Würthwein, A. Groll, G. Hempel, F. Adler-Shohet, J. Lieberman, T. Walsh
- MedicineAntimicrobial Agents and Chemotherapy
- 1 December 2005
The disposition of ABLC in neonates was similar to that observed in other age groups: weight was the only factor that influenced clearance, and it is recommended a daily dosage between 2.5 and 5.0 mg/kg for treatment of invasive Candida infections in Neonates.
Population Pharmacokinetics of Busulfan in Children: Increased Evidence for Body Surface Area and Allometric Body Weight Dosing of Busulfan in Children
- M. Trame, M. Bergstrand, M. Karlsson, J. Boos, G. Hempel
- Medicine, BiologyClinical Cancer Research
- 1 November 2011
The present study retrospectively analyzed two different data sets from three different dosing regimens by means of population pharmacokinetics using NONMEM to recommend a BSA or an allometric BW dosing regimen for individualizing busulfan therapy in children to reduce variability in busulfa exposure and to improve safety and efficacy of busulfans treatment.
Population pharmacokinetic‐pharmacodynamic modeling of moxonidine using 24‐hour ambulatory blood pressure measurements
Influence of secreted frizzled receptor protein 1 (SFRP1) on neoadjuvant chemotherapy in triple negative breast cancer does not rely on WNT signaling
It is shown that S FRP1 strongly correlates with the triple negative breast cancer subtype and that SFRP1 might be used as a marker stratifying patients to positively respond to neoadjuvant chemotherapy.