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Preparative and analytical separation of the zopiclone enantiomers and determination of their affinity to the benzodiazepine receptor binding site.
TLDR
The preparative separation of rac-zopiclone using malic acid as the resolving agent and benzodiazepine receptor binding of the isolated enantiomers was investigated, indicating a more than 50 times higher affinity of the (+)-enantiomer toward the receptor. Expand
Validated methods for direct determination of hydroquinone glucuronide and sulfate in human urine after oral intake of bearberry leaf extract by capillary zone electrophoresis.
TLDR
Two separate capillary electrophoresis methods have been developed for renal elimination of bearberry leaf extracts and are very suitable for urine analysis with large sample numbers as frequently coming up in the course of pharmaceutical bioavailability, bioequivalence and pharmacokinetic studies. Expand
Chromatographic Resolution of Chiral Drugs on Polyamides and Cellulose Triacetate
Abstract Many chiral drugs are resolved very efficiently by chromatography on optically active polyamides and microcrystalline cellulose triacetate. These adsorbents having a wide range ofExpand
[Chromatographic separation of racemic thalidomide and teratogenic activity of its enantiomers (author's transl)].
Racemic thalidomide is chromatographically separated on optically active polyamide giving both enantiomers. After i.p. administration only the S-(-)-enantiomer is teratogenic on SWS mice and NatalExpand
Stereoselective determination of ofloxacin and its metabolites in human urine by capillary electrophoresis using laser-induced fluorescence detection.
TLDR
It could be demonstrated that the renal excretion of the S-configured metabolites, especially S-desmethyl ofloxacin, within the first 20 h after dosage, is significantly lower than that of the R-enantiomers. Expand
Direct determination of paracetamol and its metabolites in urine and serum by capillary electrophoresis with ultraviolet and mass spectrometric detection.
TLDR
Simple, rapid and reliable assays could be developed that made use of some of the main advantages of this analytical technique, and were demonstrated by applying them to the analysis of urine and serum samples of healthy volunteers as well as to urine samples from children under anticancer therapy. Expand
An enantiomer-enantiomer interaction of (S)- and (R)-propafenone modifies the effect of racemic drug therapy.
TLDR
The effects of racemic drug therapy are not necessarily those predicted by summation of the effects of the individual enantiomers, as indicated by the data indicating that (R)-propafenone impairs the disposition of (S)-propacenone in humans. Expand
Determination of residues of enrofloxacin and its metabolite ciprofloxacin in chicken muscle by capillary electrophoresis using laser‐induced fluorescence detection
TLDR
A method for the residue analysis of the veterinary antimicrobial agent enrofloxacin and its active desethyl metabolite ciprofl oxacin in chicken muscle tissue has been developed and validated and allows the detection of contaminated muscle samples at the required maximum residue limit of the European Union. Expand
Racemization and hydrolysis of tropic acid alkaloids in the presence of cyclodextrins
Because of the constantly increasing demand for optically pure drugs it is of great importance to elucidate factors affecting stereochemistry, in order to provide a stable formulation with a highExpand
Investigation of praziquantel metabolism in isolated rat hepatocytes.
  • H. Meier, G. Blaschke
  • Chemistry, Medicine
  • Journal of pharmaceutical and biomedical analysis
  • 1 October 2001
TLDR
It was found that hepatocytes converted both enantiomers of PZQ to the major metabolites cis- and trans-4-hydroxypraziquantel metabolites of different, unknown structure. Expand
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