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complement pathway

Known as: complement pathways 
The complement pathway consists of a series of over thirty proteins in plasma that are part of the immune response. Activation of the complement… 
National Institutes of Health

Related topics

Related topics

9 relations

Broader (1)

Antigen-Antibody Reactions
C2 wt AlleleC4A wt AlleleC4B wt AlleleComplement C2, human

Narrower (3)

Complement ActivationComplement Pathway, AlternativeComplement Pathway, Classical

Papers overview

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Highly Cited
2015
Highly Cited
2015
Neutrophil extracellular traps can activate alternative complement pathways
The interaction between neutrophils and activation of alternative complement pathway plays a pivotal role in the pathogenesis of… 
Highly Cited
2006
Highly Cited
2006
Deficient alternative complement pathway activation due to factor D deficiency by 2 novel mutations in the complement factor D gene in a family with meningococcal infections.
The complement system is an essential element in our innate defense against infections with Neisseria meningitidis. We describe 2… 
Review
2006
Review
2006
Replication-defective viruses as vaccines and vaccine vectors.
Highly Cited
2002
Highly Cited
2002
The classical pathway is the dominant complement pathway required for innate immunity to Streptococcus pneumoniae infection in mice
The complement system is an important component of the innate immune response to bacterial pathogens, including Streptococcus… 
Review
1998
Review
1998
Therapeutic inhibition of the complement system.
The use of powerful methodologies in molecular biology, biochemistry, and physiology in the last 2 decades had led to impressive… 
Highly Cited
1992
Highly Cited
1992
Mechanism of complement activation in the hyperacute rejection of porcine organs transplanted into primate recipients.
The authors investigated the importance of natural antibody and complement in the pathogenesis of hyperacute xenograft rejection… 
Highly Cited
1988
Highly Cited
1988
Pulmonary alveolar type II epithelial cells synthesize and secrete proteins of the classical and alternative complement pathways.
The serum complement system is a major mediator of inflammation reactions. Two of the complement proteins, the third (C3) and… 
Highly Cited
1980
Highly Cited
1980
Inherited structural polymorphism of the fourth component of human complement.
Human fourth component of complement (C4) was found to be highly polymorphic by agarose gel electrophoresis of neuraminidase… 
Highly Cited
1980
Highly Cited
1980
Biosynthesis of the complement components and the regulatory proteins of the alternative complement pathway by human peripheral blood monocytes
Short-term cultures of human peripheral blood monocytes were shown to synthesize the alternative pathway complement components C3… 
Highly Cited
1977
Highly Cited
1977
Activation of the alternative complement pathway due to resistance of zymosan-bound amplification convertase to endogenous regulatory mechanisms.
The surface of zymosan (Zy), by affording a protected microenvironment for C3b and the amplification convertase stabilized by… 
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