Complement Pathway, Alternative

Known as: complement cascade, alternative pathway, Alternative Complement Pathway, complement activation, alternative pathway 
Complement activation initiated by the interaction of microbial ANTIGENS with COMPLEMENT C3B. When COMPLEMENT FACTOR B binds to the membrane-bound… (More)
National Institutes of Health

Related topics

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13 relations
CFD wt AlleleCFH wt AlleleCFP wt AlleleComplement Factor B
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Broader (1)

complement pathway

Papers overview

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Highly Cited
2011
Highly Cited
2011
Complement alternative pathway acts as a positive feedback amplification of neutrophil activation.
Complement alternative pathway plays an important, but not clearly understood, role in neutrophil-mediated diseases. We here show… (More)
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Review
2008
Review
2008
The alternative complement pathway revisited
Alternative pathway amplification plays a major role for the final effect of initial specific activation of the classical and… (More)
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Highly Cited
2008
Highly Cited
2008
Systemic Complement Activation in Age-Related Macular Degeneration
Dysregulation of the alternative pathway (AP) of complement cascade has been implicated in the pathogenesis of age-related… (More)
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Highly Cited
2006
Highly Cited
2006
Mannan-binding lectin activates C3 and the alternative complement pathway without involvement of C2.
Lectin pathway activation of C3 is known to involve target recognition by mannan-binding lectin (MBL) or ficolins and generation… (More)
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Highly Cited
2006
Highly Cited
2006
The meningococcal vaccine candidate GNA1870 binds the complement regulatory protein factor H and enhances serum resistance.
Neisseria meningitidis binds factor H (fH), a key regulator of the alternative complement pathway. A approximately 29 kD fH… (More)
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Highly Cited
2005
Highly Cited
2005
A common haplotype in the complement regulatory gene factor H (HF1/CFH) predisposes individuals to age-related macular degeneration.
Age-related macular degeneration (AMD) is the most frequent cause of irreversible blindness in the elderly in developed countries… (More)
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Highly Cited
2003
Highly Cited
2003
Role for the alternative complement pathway in ischemia/reperfusion injury.
The terminal complement components play an important role in mediating tissue injury after ischemia and reperfusion (I/R) injury… (More)
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Highly Cited
1997
Highly Cited
1997
Abrogation of the alternative complement pathway by targeted deletion of murine factor B.
To investigate the role of complement protein factor B (Bf) and alternative pathway activity in vivo, and to test the… (More)
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Highly Cited
1995
Highly Cited
1995
Natural hemolytic and bactericidal activities of sea bream Sparus aurata serum are effected by the alternative complement pathway.
Sea bream serum displayed bactericidal and hemolytic activities. These activities were depleted when serum was incubated with… (More)
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Highly Cited
1988
Highly Cited
1988
Antiphagocytic activity of streptococcal M protein: selective binding of complement control protein factor H.
Isolated complement components were used to study the regulation of the alternative complement pathway C3 convertase (EC 3.4.21… (More)
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