Complement Factor B

Known as: C3PA, Complement Protein Factor B, Complement Protein B 
A glycine-rich, heat-labile serum glycoprotein that contains a component of the C3 CONVERTASE ALTERNATE PATHWAY (C3bBb). Bb, a serine protease, is… (More)
National Institutes of Health

Papers overview

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Highly Cited
2014
Highly Cited
2014
The lowest free-energy conformations are identified by structure clustering. A second round of assembly simulation is conducted… (More)
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Highly Cited
2011
Highly Cited
2011
Common polymorphisms in complement alternative pathway (AP) proteins C3 (C3(R102G)), factor B (fB(R32Q)), and factor H (fH(V62I… (More)
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Review
2010
Review
2010
During the past ten years, dramatic advances have been made in unraveling the biological bases of age-related macular… (More)
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Highly Cited
2007
Highly Cited
2007
Hemolytic uremic syndrome (HUS) is an important cause of acute renal failure in children. Mutations in one or more genes encoding… (More)
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Highly Cited
2007
Highly Cited
2007
Age-related macular degeneration (AMD) is a devastating disorder of the central retina, causing significant visual impairment for… (More)
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Highly Cited
2006
Highly Cited
2006
Age-related macular degeneration (AMD) is the most common form of irreversible blindness in developed countries. Variants in the… (More)
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Highly Cited
2002
Highly Cited
2002
The alternative pathway of complement is activated continuously in vivo through the C3 'tick-over' pathway. This pathway is… (More)
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Highly Cited
2001
Highly Cited
2001
Flavopiridol (L86-8275, HMR1275) is a cyclin-dependent kinase (Cdk) inhibitor in clinical trials as a cancer therapy that has… (More)
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Highly Cited
1997
Highly Cited
1997
To investigate the role of complement protein factor B (Bf) and alternative pathway activity in vivo, and to test the… (More)
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Highly Cited
1984
Highly Cited
1984
Four human complement genes, which have previously been mapped between HLA-D and HLA-B on chromosome 6, have now been aligned on… (More)
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