Complement Factor B

Known as: C3PA, Complement Protein Factor B, Complement Protein B 
A glycine-rich, heat-labile serum glycoprotein that contains a component of the C3 CONVERTASE ALTERNATE PATHWAY (C3bBb). Bb, a serine protease, is… (More)
National Institutes of Health

Related topics

Related topics

15 relations
CFB geneComplement 3Complement C3 ConvertasesComplement C3b
(More)

Narrower (2)

Complement Factor BaProperdin Factor Bf

Broader (1)

Immunologic Factors

Papers overview

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Highly Cited
2014
Highly Cited
2014
The I-TASSER Suite: protein structure and function prediction
The lowest free-energy conformations are identified by structure clustering. A second round of assembly simulation is conducted… (More)
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Highly Cited
2011
Highly Cited
2011
Common polymorphisms in C3, factor B, and factor H collaborate to determine systemic complement activity and disease risk.
Common polymorphisms in complement alternative pathway (AP) proteins C3 (C3(R102G)), factor B (fB(R32Q)), and factor H (fH(V62I… (More)
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Review
2010
Review
2010
The pivotal role of the complement system in aging and age-related macular degeneration: Hypothesis re-visited
During the past ten years, dramatic advances have been made in unraveling the biological bases of age-related macular… (More)
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Highly Cited
2007
Highly Cited
2007
Gain-of-function mutations in complement factor B are associated with atypical hemolytic uremic syndrome.
Hemolytic uremic syndrome (HUS) is an important cause of acute renal failure in children. Mutations in one or more genes encoding… (More)
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Highly Cited
2007
Highly Cited
2007
Protective effect of complement factor B and complement component 2 variants in age-related macular degeneration.
Age-related macular degeneration (AMD) is a devastating disorder of the central retina, causing significant visual impairment for… (More)
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Highly Cited
2006
Highly Cited
2006
Variation in factor B (BF) and complement component 2 (C2) genes is associated with age-related macular degeneration
Age-related macular degeneration (AMD) is the most common form of irreversible blindness in developed countries. Variants in the… (More)
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Highly Cited
2002
Highly Cited
2002
Uncontrolled C3 activation causes membranoproliferative glomerulonephritis in mice deficient in complement factor H
The alternative pathway of complement is activated continuously in vivo through the C3 'tick-over' pathway. This pathway is… (More)
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Highly Cited
2001
Highly Cited
2001
Flavopiridol inactivates P-TEFb and blocks most RNA polymerase II transcription in vivo.
Flavopiridol (L86-8275, HMR1275) is a cyclin-dependent kinase (Cdk) inhibitor in clinical trials as a cancer therapy that has… (More)
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Highly Cited
1997
Highly Cited
1997
Abrogation of the alternative complement pathway by targeted deletion of murine factor B.
To investigate the role of complement protein factor B (Bf) and alternative pathway activity in vivo, and to test the… (More)
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Highly Cited
1984
Highly Cited
1984
A molecular map of the human major histocompatibility complex class III region linking complement genes C4, C2 and factor B
Four human complement genes, which have previously been mapped between HLA-D and HLA-B on chromosome 6, have now been aligned on… (More)
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