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Diagnostic criteria and classification of mastocytosis: a consensus proposal.
Criteria to delineate categories of mastocytosis together with an updated consensus classification system are proposed and proposed, based on typical clinical and histological skin lesions and absence of definitive signs (criteria) of systemic involvement. Expand
Leukotrienes and other products of the 5-lipoxygenase pathway. Biochemistry and relation to pathobiology in human diseases.
Since the chemical characterization of the slow-reacting substance of anaphylaxis as several cysteinyl leukotrienes and the identification and biochemical assessment of the enzymes in the 5-lipoxygenase pathway, the products of this pathway have been implicated in a much broader variety of functions. Expand
Contaminated heparin associated with adverse clinical events and activation of the contact system.
An assay to assess the amidolytic activity of kallikrein can supplement analytic tests to protect the heparin supply chain by screening for OSCS and other highly sulfated polysaccharide contaminants of hepar in that can activate the contact system. Expand
Developmental checkpoints of the basophil/mast cell lineages in adult murine hematopoiesis.
Basophils and mast cells, which are selectively endowed with the high-affinity IgE receptor and mediate a range of adaptive and innate immune responses, have an unknown developmental relationship.Expand
Cysteinyl leukotriene receptor 1 is also a pyrimidinergic receptor and is expressed by human mast cells
The cysteinyl leukotrienes (cys-LTs) LTC4, LTD4, and LTE4 are a class of peptide-conjugated lipids formed from arachidonic acid and released during activation of mast cells (MCs). We now report thatExpand
Expression cloning of a cDNA for human leukotriene C4 synthase, an integral membrane protein conjugating reduced glutathione to leukotriene A4.
LTC4 synthase is distinct from the known GSH S-transferases by nucleotide and consensus amino acid sequences, and its GSH-conjugating function represents a distinct integral membrane protein belonging to a distinct gene family. Expand
Developmental origin and functional specialization of mast cell subsets.
The current understanding of how these unique immunocytes arise, traffic to various sites, and may or may not mature into tissue-directed granulated phenotypes are discussed and whether a granulated end stage is their only intended role is queried. Expand
Prostaglandin D2 generation after activation of rat and human mast cells with anti-IgE.
There was a linear relationship between the net quantities of PGD2 generated and of histamine secreted from dispersed human pulmonary cells when the number of mast cells was varied but the total number of cells was held constant, indicating that it is the numberof mast cells participating in IgE-dependent activation, rather than total mast cell number, that determines PGD 2 generation. Expand
Control of the amplification convertase of complement by the plasma protein beta1H.
An inhibitory activity for an erythrocyte in termediate bearing the properdin (P)-stabilized amplification C3 convertase, PC3bBb, was recognized in whole normal human serum and separated from C3bExpand