TAM Receptors Are Pleiotropic Inhibitors of the Innate Immune Response
- C. Rothlin, Sourav Ghosh, E. Zúñiga, M. Oldstone, G. Lemke
- BiologyCell
- 14 December 2007
Interleukin-10 determines viral clearance or persistence in vivo
- D. Brooks, M. Trifilo, K. Edelmann, L. Teyton, D. McGavern, M. Oldstone
- Biology, MedicineNature Network Boston
- 15 October 2006
It is shown that persistent viral infection in mice results in a significant upregulation of interleukin (IL)-10 by antigen-presenting cells, leading to impaired T-cell responses, and that a therapy to neutralize IL-10 results in T- cell recovery and the prevention of viral persistence.
Antiviral pressure exerted by HIV-l-specific cytotoxic T lymphocytes (CTLs) during primary infection demonstrated by rapid selection of CTL escape virus
- P. Borrow, H. Lewicki, G. Shaw
- BiologyNature Network Boston
- 1 February 1997
It is shown that in a patient whose early CTL response was focused on a highly immunodominant epitope in gp160, there was rapid elimination of the transmitted virus strain and selection for a virus population bearing amino acid changes at a single residue within this epitope, which conferred escape from recognition by epitope-specific CTL.
Selection of genetic variants of lymphocytic choriomeningitis virus in spleens of persistently infected mice. Role in suppression of cytotoxic T lymphocyte response and viral persistence
- R. Ahmed, A. Salmi, L. Butler, J. Chiller, M. Oldstone
- BiologyJournal of Experimental Medicine
- 1 August 1984
The results show that LCMV variants that emerge during infection in vivo play a crucial role in the suppression of virus-specific CTL responses and in the maintenance of virus persistence.
Virus-specific CD8+ cytotoxic T-lymphocyte activity associated with control of viremia in primary human immunodeficiency virus type 1 infection
- P. Borrow, H. Lewicki, B. Hahn, G. Shaw, M. Oldstone
- Medicine, BiologyJournal of Virology
- 1 September 1994
HIV-1-specific CTL activity is a major component of the host immune response associated with the control of virus replication following primary HIV-1 infection and have important implications for the design of antiviral vaccines.
Neurologic disease induced in transgenic mice by cerebral overexpression of interleukin 6.
- I. Campbell, C. Abraham, L. Mucke
- Biology, MedicineProceedings of the National Academy of Sciences…
- 1 November 1993
Transgenic mice generated in which the cytokine interleukin 6 (IL-6), under the regulatory control of the glial fibrillary acidic protein gene promoter, was overexpressed in the CNS exhibited a neurologic syndrome the severity of which correlated with the levels of cerebral IL-6 expression.
Anchorless Prion Protein Results in Infectious Amyloid Disease Without Clinical Scrapie
- B. Chesebro, M. Trifilo, M. Oldstone
- BiologyScience
- 3 June 2005
In scrapie-infected transgenic mice expressing prion protein (PrP) lacking the glycosylphosphatidylinositol (GPI) membrane anchor, abnormal protease-resistant PrPres was deposited as amyloid plaques, rather than the usual nonamyloid form of PrPres, which may play a role in the pathogenesis of prion diseases.
Virus infection triggers insulin-dependent diabetes mellitus in a transgenic model: Role of anti-self (virus) immune response
- M. Oldstone, M. Nerenberg, P. Southern, J. Price, H. Lewicki
- BiologyCell
- 19 April 1991
Persistent LCMV Infection Is Controlled by Blockade of Type I Interferon Signaling
- J. Teijaro, C. Ng, M. Oldstone
- Biology, MedicineScience
- 12 April 2013
A direct causal link between IFN-I signaling, immune activation, negative immune regulator expression, lymphoid tissue disorganization, and virus persistence is demonstrated and the results suggest that therapies targeting IFn-I may help control persistent virus infections.
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