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Essentials of Glycobiology
General principles - historical background and overview saccharide structure and nomenclature evolution of glycan diversity protein-glycan Interactions exploring the biological roles of glycans… Expand
Siglecs and their roles in the immune system
Cell surfaces in the immune system are richly equipped with a complex mixture of glycans, which can be recognized by diverse glycan-binding proteins. The Siglecs are a family of sialic-acid-binding… Expand
Initial sequence of the chimpanzee genome and comparison with the human genome
Here we present a draft genome sequence of the common chimpanzee (Pan troglodytes). Through comparison with the human genome, we have generated a largely complete catalogue of the genetic differences… Expand
Biological roles of oligosaccharides: all of the theories are correct
- A. Varki
- Biology, Medicine
- 1 April 1993
Abstract Many different theories have been advanced concerning the biological roles of the oligosaccharide units of individual classes of glycoconjugates. Analysis of the evidence indicates that… Expand
Intra- and Interspecific Variation in Primate Gene Expression Patterns
Although humans and their closest evolutionary relatives, the chimpanzees, are 98.7% identical in their genomic DNA sequences, they differ in many morphological, behavioral, and cognitive aspects.… Expand
Heparin and cancer revisited: Mechanistic connections involving platelets, P-selectin, carcinoma mucins, and tumor metastasis
- L. Borsig, R. Wong, J. Feramisco, D. R. Nadeau, N. Varki, A. Varki
- Biology, Medicine
- Proceedings of the National Academy of Sciences…
- 13 March 2001
Independent studies indicate that expression of sialylated fucosylated mucins by human carcinomas portends a poor prognosis because of enhanced metastatic spread of tumor cells, that carcinoma… Expand
Chemical Diversity in the Sialic Acids and Related α-Keto Acids: An Evolutionary Perspective
Siglecs--the major subfamily of I-type lectins.
Animal glycan-recognizing proteins can be broadly classified into two groups-lectins (which typically contain an evolutionarily conserved carbohydrate-recognition domain [CRD]) and sulfated… Expand
Chemical diversity in the sialic acids and related alpha-keto acids: an evolutionary perspective.
The glycan chains of vertebrate glycoconjugates are composed mostly of fiveand six-carbon sugars. One striking exception is the family of sialic acids (Sia), which are R-keto acids with a nine-carbon… Expand
Differential interactions of heparin and heparan sulfate glycosaminoglycans with the selectins. Implications for the use of unfractionated and low molecular weight heparins as therapeutic agents.
- A. Koenig, K. Norgard-Sumnicht, R. Linhardt, A. Varki
- Medicine, Chemistry
- The Journal of clinical investigation
- 15 February 1998
The selectins are calcium-dependent C-type lectins that bind certain sialylated, fucosylated, sulfated glycoprotein ligands. L-selectin also recognizes endothelial proteoglycans in a… Expand