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Essentials of Glycobiology
General principles - historical background and overview saccharide structure and nomenclature evolution of glycan diversity protein-glycan Interactions exploring the biological roles of glycans
Siglecs and their roles in the immune system
TLDR
The postulated functions of the recently discovered CD33-related Siglecs are discussed and the factors that seem to be driving their rapid evolution are considered.
Initial sequence of the chimpanzee genome and comparison with the human genome
TLDR
It is found that the patterns of evolution in human and chimpanzee protein-coding genes are highly correlated and dominated by the fixation of neutral and slightly deleterious alleles.
Intra- and Interspecific Variation in Primate Gene Expression Patterns
TLDR
Three mouse species that are approximately as related to each other as are humans, chimpanzees, and orangutans are studied, and species-specific gene expression patterns indicating that changes in protein and gene expression have been particularly pronounced in the human brain are identified.
Biological roles of glycans
  • A. Varki
  • Biology, Chemistry
    Glycobiology
  • 28 December 2016
TLDR
It is time for the diverse functional roles of glycans to be fully incorporated into the mainstream of biological sciences, as they are no different from other major macromolecular building blocks of life, simply more rapidly evolving and complex.
Chemical diversity in the sialic acids and related alpha-keto acids: an evolutionary perspective.
TLDR
Unlike the other vertebrate monosaccharides, sialic acids are not ubiquitous in nature and seem to be predominantly found in two distinct branches of the tree of life: in the deuterostome lineage of animals (vertebrates and a few higher invertebrates such as starfish and in certain types of bacteria.
Differential interactions of heparin and heparan sulfate glycosaminoglycans with the selectins. Implications for the use of unfractionated and low molecular weight heparins as therapeutic agents.
TLDR
High-dose unfractionated heparin should be investigated as a treatment option for acute and chronic diseases in which P- and L-selectin play pathological roles, and the current switchover to low-molecular weight heparins may come at some loss of this effect.
Methods and Applications
TLDR
The aim of the research presented in this thesis is to create new methods for design for manufacturing, by using several approaches of KE, and find the beneficial and less beneficial aspects of these methods in comparison to each other and earlier research.
Siglecs--the major subfamily of I-type lectins.
TLDR
The Siglecs can be divided into two groups: an evolutionarily conserved subgroup (Siglecs-1, -2, and -4) and a CD33/S Siglec-3-related subgroup, which appear to be rapidly evolving.
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