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Essentials of Glycobiology
General principles - historical background and overview saccharide structure and nomenclature evolution of glycan diversity protein-glycan Interactions exploring the biological roles of glycansExpand
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Siglecs and their roles in the immune system
Cell surfaces in the immune system are richly equipped with a complex mixture of glycans, which can be recognized by diverse glycan-binding proteins. The Siglecs are a family of sialic-acid-bindingExpand
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Initial sequence of the chimpanzee genome and comparison with the human genome
Here we present a draft genome sequence of the common chimpanzee (Pan troglodytes). Through comparison with the human genome, we have generated a largely complete catalogue of the genetic differencesExpand
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Biological roles of oligosaccharides: all of the theories are correct
  • A. Varki
  • Biology, Medicine
  • Glycobiology
  • 1 April 1993
Abstract Many different theories have been advanced concerning the biological roles of the oligosaccharide units of individual classes of glycoconjugates. Analysis of the evidence indicates thatExpand
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Intra- and Interspecific Variation in Primate Gene Expression Patterns
Although humans and their closest evolutionary relatives, the chimpanzees, are 98.7% identical in their genomic DNA sequences, they differ in many morphological, behavioral, and cognitive aspects.Expand
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Heparin and cancer revisited: Mechanistic connections involving platelets, P-selectin, carcinoma mucins, and tumor metastasis
Independent studies indicate that expression of sialylated fucosylated mucins by human carcinomas portends a poor prognosis because of enhanced metastatic spread of tumor cells, that carcinomaExpand
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Siglecs--the major subfamily of I-type lectins.
Animal glycan-recognizing proteins can be broadly classified into two groups-lectins (which typically contain an evolutionarily conserved carbohydrate-recognition domain [CRD]) and sulfatedExpand
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Chemical diversity in the sialic acids and related alpha-keto acids: an evolutionary perspective.
The glycan chains of vertebrate glycoconjugates are composed mostly of fiveand six-carbon sugars. One striking exception is the family of sialic acids (Sia), which are R-keto acids with a nine-carbonExpand
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Differential interactions of heparin and heparan sulfate glycosaminoglycans with the selectins. Implications for the use of unfractionated and low molecular weight heparins as therapeutic agents.
The selectins are calcium-dependent C-type lectins that bind certain sialylated, fucosylated, sulfated glycoprotein ligands. L-selectin also recognizes endothelial proteoglycans in aExpand
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