Complement Pathway, Classical

Known as: Classical Complement Activation Pathway, Classical Complement Pathway, Complement Activation Pathway, Classical 
Complement activation initiated by the binding of COMPLEMENT C1 to ANTIGEN-ANTIBODY COMPLEXES at the COMPLEMENT C1Q subunit. This leads to the… (More)
National Institutes of Health

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14 relations
C1QA wt AlleleC2 wt AlleleC4A wt AlleleC4B wt Allele
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Broader (1)

complement pathway

Papers overview

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Highly Cited
2007
Highly Cited
2007
Complement activation in experimental and human temporal lobe epilepsy
We investigated the involvement of the complement cascade during epileptogenesis in a rat model of temporal lobe epilepsy (TLE… (More)
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Highly Cited
2002
Highly Cited
2002
I-PLA2 Activation during Apoptosis Promotes the Exposure of Membrane Lysophosphatidylcholine Leading to Binding by Natural Immunoglobulin M Antibodies and Complement Activation
Deficiency of serum immunoglobulin (Ig)M is associated with the development of a lupus-like disease in mice. Recent studies… (More)
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Highly Cited
2001
Highly Cited
2001
Generation of C-reactive protein and complement components in atherosclerotic plaques.
C-reactive protein (CRP) and complement are hypothesized to be major mediators of inflammation in atherosclerotic plaques. We… (More)
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Highly Cited
2001
Highly Cited
2001
Complement component C3 is not required for full expression of immune complex glomerulonephritis in MRL/lpr mice.
Complement activation and tissue deposition of complement fragments occur during disease progression in lupus nephritis. Genetic… (More)
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Highly Cited
1999
Highly Cited
1999
Complement activation in acute humoral renal allograft rejection: diagnostic significance of C4d deposits in peritubular capillaries.
The distinction between acute humoral rejection (AHR) and acute cellular rejection (ACR) in renal allografts is therapeutically… (More)
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Highly Cited
1998
Highly Cited
1998
Complement-dependent Proinflammatory Properties of the Alzheimer's Disease β-Peptide
Large numbers of neuritic plaques (NP), largely composed of a fibrillar insoluble form of the beta-amyloid peptide (Abeta), are… (More)
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Highly Cited
1992
Highly Cited
1992
Activation of the classical complement pathway by mannose-binding protein in association with a novel C1s-like serine protease
Serum mannose-binding protein (MBP) is a C-type lectin that binds to terminal mannose and N-acetylglucosamine moieties present on… (More)
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Highly Cited
1992
Highly Cited
1992
Vaccinia virus complement-control protein prevents antibody-dependent complement-enhanced neutralization of infectivity and contributes to virulence.
The role of a viral gene product in evasion of the host immune response was investigated. The antibody-dependent complement… (More)
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Highly Cited
1984
Highly Cited
1984
Activation of human complement by the pneumococcal toxin pneumolysin.
Highly purified pneumolysin (at a concentration of 10 micrograms/ml) caused significant activation of human complement, as… (More)
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Highly Cited
1976
Highly Cited
1976
Lysis of RNA tumor viruses by human serum: direct antibody-independent triggering of the classical complement pathway
In earlier studies we found that human serum, but not serum from multiple other species, inactivated and lysed oncornaviruses… (More)
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