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Complement Pathway, Classical

Known as: Classical Complement Activation Pathway, Classical Complement Pathway, Complement Activation Pathway, Classical 
Complement activation initiated by the binding of COMPLEMENT C1 to ANTIGEN-ANTIBODY COMPLEXES at the COMPLEMENT C1Q subunit. This leads to the… 
National Institutes of Health

Related topics

Related topics

14 relations
C1QA wt AlleleC2 wt AlleleC4A wt AlleleC4B wt Allele

Broader (1)

complement pathway

Papers overview

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Review
2003
Review
2003
Rheumatic syndromes associated with complement deficiency
Deficiency of an early component of the classical complement pathway, C1q, C1r/C1s, C4, or C2, regularly produces autoimmunity in… 
2003
2003
The phosphocholine and the polycation-binding sites on rabbit C-reactive protein are structurally and functionally distinct.
Highly Cited
2000
Highly Cited
2000
Serum Amyloid P Component Bound to Gram-Negative Bacteria Prevents Lipopolysaccharide-Mediated Classical Pathway Complement Activation
ABSTRACT Although serum amyloid P component (SAP) is known to bind many ligands, its biological function is not yet clear… 
Highly Cited
1995
Highly Cited
1995
Diversity of Sites for Measles Virus Binding and for Inactivation of Complement C3b and C4b on Membrane Cofactor Protein CD46 (*)
The complement system membrane cofactor protein (MCP) CD46 serves as a C3b/C4b inactivating factor for the protection of host… 
1995
1995
Circulating levels of mannose binding protein in human immunodeficiency virus infection.
Highly Cited
1990
Highly Cited
1990
Complement-activated oligodendroglia: A new pathogenic entity identified by immunostaining with antibodies to human complement proteins C3d and C4d
Highly Cited
1985
Highly Cited
1985
C-reactive protein mediates the solubilization of nuclear DNA by complement in vitro
We have studied the interaction of C-reactive protein (CRP)-chromatin complexes with serum. The amount of chromatin solubilized… 
1985
1985
Depressed classical complement pathway activities in chronic lymphocytic leukaemia.
Haemolytic activities of the classical and alternative complement pathways, and levels of C1, C4, C3, factor B and C1 inhibitor… 
Highly Cited
1985
Highly Cited
1985
Influence of genetically inherited complement deficiencies on humoral immune response in guinea pigs.
To assess the role of complement in the induction of the humoral immune response, we studied the antibody response of guinea pigs… 
1983
1983
Deficient Classical Complement Pathway Activity in Newborn Sera
Summary: The bactericidal activity of 20 maternal-neonatal paired sera was assessed employing a clinical type la, group B… 
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