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Human C-reactive protein: expression, structure, and function.
  • J. Volanakis
  • Medicine, Biology
  • Molecular immunology
  • 1 August 2001
The weight of the evidence is that CRP like other acute-phase proteins is a component first line of innate host defense and appears to be host defense against bacterial pathogens and clearance of apoptotic and necrotic cells. Expand
Topology and Structure of the C1q-Binding Site on C-Reactive Protein1
The host defense functions of human C-reactive protein (CRP) depend to a great extent on its ability to activate the classical complement pathway. The aim of this study was to define the topology andExpand
Specificity of C-Reactive Protein for Choline Phosphate Residues of Pneumococcal C-Polysaccharide
Results of these experiments indicated that choline phosphate is the most active inhibitor of CRP-C-polysaccharide precipitation yet described, and suggested that this compound might provide the major reacting site of C-poly Saccharide. Expand
Three dimensional structure of human C-reactive protein
The structure of the classical acute phase reactant human C-reactive protein provides evidence that phosphocholine binding is mediated through calcium and a hydrophobic pocket centred on Phe 66. TheExpand
Susceptibility Locus for IgA Deficiency and Common Variable Immunodeficiency in the HLA-DR3, -B8, -A1 Haplotypes
Crossover events within the MHC indicated a susceptibility locus for IgAD/CVID between the class III markers D821/D823 and HLA-B8, a region populated by 21 genes that include tumor necrosis factor alpha and lymphotoxins alpha and beta. Expand
Role of complement in C-reactive-protein-mediated protection of mice from Streptococcus pneumoniae
The data suggest that in vivo complement and CRP amplify each other's protective capacity, particularly during the early course of infection. Expand
Interaction of C-reactive protein complexes with the complement system. I. Consumption of human complement associated with the reaction of C-reactive protein with pneumococcal C-polysaccharide and
These combined data have permitted the conclusion that complement consumption was attributable to CRP complexes and that it proceeded via the classical pathway independent of the presence of specificExpand
The human complement system in health and disease
This chapter discusses the development of Clinically Useful Agents to Control Complement-Mediated Tissue Damage and the role of Complement in Immune Complex Diseases. Expand
Interaction of C-reactive protein with artificial phosphatidylcholine bilayers
It is reported here that binding of CRP to model membranes of PC requires the incorporation into the bilayer of lysophosphatidylcholine (LPC), providing a possible biochemical explanation for binding ofCRP to damaged but not intact cell membranes. Expand
Recombinant and native zymogen forms of human complement factor D.
A full-length cDNA clone encoding human factor D is expressed by using a baculovirus expression system and results suggested that the recombinant protein was the elusive zymogen of factor D. Expand