Human C-reactive protein: expression, structure, and function.
- J. Volanakis
- BiologyMolecular Immunology
- 1 August 2001
Topology and Structure of the C1q-Binding Site on C-Reactive Protein1
- A. Agrawal, A. Shrive, T. Greenhough, J. Volanakis
- Biology, ChemistryJournal of Immunology
- 15 March 2001
The host defense functions of human C-reactive protein (CRP) depend to a great extent on its ability to activate the classical complement pathway. The aim of this study was to define the topology and…
Interaction of C-reactive protein with artificial phosphatidylcholine bilayers
- J. Volanakis, K. Wirtz
- Biology, ChemistryNature
- 13 September 1979
It is reported here that binding of CRP to model membranes of PC requires the incorporation into the bilayer of lysophosphatidylcholine (LPC), providing a possible biochemical explanation for binding ofCRP to damaged but not intact cell membranes.
Three dimensional structure of human C-reactive protein
- A. Shrive, Graham M.T. Gheetham, T. Greenhough
- Biology, ChemistryNature Structural Biology
- 1 April 1996
The structure of the classical acute phase reactant human C-reactive protein provides evidence that phosphocholine binding is mediated through calcium and a hydrophobic pocket centred on Phe 66. The…
Major histocompatibility complex class III genes and susceptibility to immunoglobulin A deficiency and common variable immunodeficiency.
- J. Volanakis, Z. Zhu, M. Cooper
- Biology, MedicineJournal of Clinical Investigation
- 1 June 1992
Detailed analysis of MHC haplotypes suggests that a susceptibility gene or genes for both immunodeficiencies are located within the class III region of the MHC, possibly between the C4B and C2 genes.
Susceptibility Locus for IgA Deficiency and Common Variable Immunodeficiency in the HLA-DR3, -B8, -A1 Haplotypes
- H. Schroeder, Z. Zhu, J. Volanakis
- Medicine, BiologyMolecular Medicine
- 1 February 1998
Crossover events within the MHC indicated a susceptibility locus for IgAD/CVID between the class III markers D821/D823 and HLA-B8, a region populated by 21 genes that include tumor necrosis factor alpha and lymphotoxins alpha and beta.
Role of complement in C-reactive-protein-mediated protection of mice from Streptococcus pneumoniae
- A. Szalai, D. Briles, J. Volanakis
- Biology, MedicineInfection and Immunity
- 1 November 1996
The data suggest that in vivo complement and CRP amplify each other's protective capacity, particularly during the early course of infection.
Complement activation in factor D-deficient mice
- Yuanyuan Xu, Minghe Ma, G. Ippolito, H. Schroeder, M. Carroll, J. Volanakis
- Biology, MedicineProceedings of the National Academy of Sciences…
- 27 November 2001
Results suggest that in mouse proteolytic cleavage of factor B by factor D is not an absolute requirement for the zymogen to active enzyme conformational transition of CVF-bound factor B, and suggests a significant contribution of the alternative pathway to antibacterial host defense early after infection.
Interaction of C-reactive protein complexes with the complement system. I. Consumption of human complement associated with the reaction of C-reactive protein with pneumococcal C-polysaccharide and…
- M. Kaplan, J. Volanakis
- Medicine, BiologyJournal of Immunology
- 1 June 1974
The combined data have permitted the conclusion that complement consumption was attributable to CRP complexes and that it proceeded via the classical pathway independent of the presence of specific antibody or immunoglobulin.
Recombinant and native zymogen forms of human complement factor D.
- Y. Yamauchi, J. Stevens, K. Macon, J. Volanakis
- BiologyJournal of Immunology
- 1 April 1994
A full-length cDNA clone encoding human factor D is expressed by using a baculovirus expression system and results suggested that the recombinant protein was the elusive zymogen of factor D.
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