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clinafloxacin

Known as: 3-Quinolinecarboxylic acid, 7-(3-amino-1-pyrrolidinyl)-8-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-, 7-(3-amino-1-pyrrolidinyl)-8-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid, 7-(3-aminopyrrolidin-1-yl)-8-chloro-1-cyclopropyl-6-fluoro-4-oxoquinoline-3-carboxylic acid 
 
National Institutes of Health

Related topics

Related topics

9 relations

Narrower (3)

AM 1091CI 960PD 127,391

Broader (3)

Anti-Bacterial AgentsFluoroquinolonesTopoisomerase II Inhibitors
Clinafloxacin HydrochlorideClinafloxacin:Susc:Pt:Isolate:OrdQn:Gradient stripClinafloxacin:Susceptibility:Point in time:Isolate:Quantitative or Ordinal

Papers overview

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Highly Cited
2009
Highly Cited
2009
Structural insight into the quinolone–DNA cleavage complex of type IIA topoisomerases
Type II topoisomerases alter DNA topology by forming a covalent DNA-cleavage complex that allows DNA transport through a double… Expand
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Review
2005
Review
2005
Treatment and control of severe infections caused by multiresistant Pseudomonas aeruginosa.
Pseudomonas aeruginosa is one of the leading causes of nosocomial infections. Severe infections, such as pneumonia or bacteraemia… Expand
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Highly Cited
2005
Highly Cited
2005
Toxicity of fluoroquinolone antibiotics to aquatic organisms.
Toxicity tests were performed with seven fluoroquinolone antibiotics, ciprofloxacin, lomefloxacin, ofloxacin, levofloxacin… Expand
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2001
2001
Results of a clinical trial of clinafloxacin versus imipenem/cilastatin for intraabdominal infections.
OBJECTIVE Clinafloxacin is a novel quinolone with wide activity against the plethora of microorganisms encountered in… Expand
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Review
2000
Review
2000
The fluoroquinolone antibacterials: past, present and future perspectives.
The history of the development of the quinolones is described from the first quinolone, nalidixic acid, via the first 6… Expand
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Review
1999
Review
1999
Toxicity of Quinolones
Reactions of the gastrointestinal tract, the CNS and the skin are the most often observed adverse effects during therapy with… Expand
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Highly Cited
1998
Highly Cited
1998
DNA gyrase and topoisomerase IV are dual targets of clinafloxacin action in Streptococcus pneumoniae.
We examined the response of Streptococcus pneumoniae 7785 to clinafloxacin, a novel C-8-substituted fluoroquinolone which is… Expand
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Highly Cited
1998
Highly Cited
1998
In vitro and in vivo activities of moxifloxacin and clinafloxacin against Mycobacterium tuberculosis.
On 10% oleic acid-albumin-dextrose-catalase-enriched 7H11 agar medium, the MIC at which 90% of the isolates are inhibited for 20… Expand
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Highly Cited
1997
Highly Cited
1997
Comparison of the antibacterial activities of the quinolones Bay 12-8039, gatifloxacin (AM 1155), trovafloxacin, clinafloxacin, levofloxacin and ciprofloxacin.
The in-vitro activities of the quinolones Bay 12-8039, gatifloxacin (AM 1155), trovafloxacin, clinafloxacin, levofloxacin and… Expand
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Highly Cited
1997
Highly Cited
1997
Reappraisal of the antimicrobial susceptibilities of Chryseobacterium and Flavobacterium species and methods for reliable susceptibility testing.
Several Flavobacterium species, comprising a heterogeneous group of gram-negative bacilli that are capable of causing… Expand
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