M. Jacobs

Publications490
h-index72
Citations20,047
Highly Influential Citations720
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Antimicrobial Resistance in Haemophilus influenzae
TLDR
Haemophilus influenzae is a major community-acquired pathogen causing significant morbidity and mortality worldwide, and strains with alterations in penicillin binding proteins, particularly PBP3 (β-lactamase negative ampicillin resistant and β-l lactamase positive amoxicillin-clavulanate resistant), are increasing in prevalence.
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The Alexander Project 1998-2000: susceptibility of pathogens isolated from community-acquired respiratory tract infection to commonly used antimicrobial agents.
TLDR
These data demonstrate the continued evolution of and geographical variation in bacterial resistance and highlight the need for appropriate prescribing of antimicrobials in CARTI, using agents with adequate activity, based on local susceptibility profiles and PK/PD parameters.
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Analysis of Antibiotic Resistance Genes in Multidrug-Resistant Acinetobacter sp. Isolates from Military and Civilian Patients Treated at the Walter Reed Army Medical Center
TLDR
A “snapshot” of the complex genetic background responsible for antimicrobial resistance in Acinetobacter spp.
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Molecular dissection of the evolution of carbapenem-resistant multilocus sequence type 258 Klebsiella pneumoniae
Significance Carbapenem-resistant Klebsiella pneumoniae has emerged globally as a multidrug-resistant hospital pathogen for which there are few treatment options. Clinical isolates classified by…
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Resistance to Colistin in Acinetobacter baumannii Associated with Mutations in the PmrAB Two-Component System
TLDR
expression of pmrA was increased in Colr mutants, but not at a low pH, suggesting that additional regulatory factors remain to be discovered, and growth in ferric chloride conferred a small protective effect.
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Intercontinental spread of a multiresistant clone of serotype 23F Streptococcus pneumoniae.
TLDR
The findings demonstrate that the Spanish and Cleveland isolates are clonally related and suggest that this antibiotic resistant clone of serotype 23F S. pneumoniae has spread intercontinentally from Spain to the United States.
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Mutations in 23S rRNA and Ribosomal Protein L4 Account for Resistance in Pneumococcal Strains Selected In Vitro by Macrolide Passage
TLDR
To the authors' knowledge, this is the first description of mutations in 23S rRNA genes or ribosomal proteins in macrolide-resistant S. pneumoniae strains.
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Antimicrobial Treatment Guidelines for Acute Bacterial Rhinosinusitis
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Relationship between bacterial load, species virulence, and transfusion reaction with transfusion of bacterially contaminated platelets.
TLDR
Improved detection methods or use of pathogen inactivation technology are needed to eliminate the major infectious hazard of platelet transfusion from July 1991 through December 2006.
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Two New Mechanisms of Macrolide Resistance in Clinical Strains ofStreptococcus pneumoniae from Eastern Europe and North America
TLDR
Twenty strains with unusual ML or MSB phenotypes which did not harbor erm(B) ormef(A) phenotypes were studied and macrolide resistance mechanisms from clinical isolates are similar to those recently described for laboratory-derived mutants.
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