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The properties of several new, investigational quinolones are reviewed. Desirable characteristics of new quinolones are improved… Expand The in vitro activity of clinafloxacin (formerly CI-960, AM-1091, PD-127391) was compared with other fluoroquinolones… Expand A collection of ciprofloxacin-resistant organisms (200 strains) was developed among 300 total test strains to "challenge" the… Expand The quinolone class of antibacterial agents has evolved rapidly to emerge as one of the most effective classes of drugs in the… Expand The in-vitro activities of two new fluoroquinolones, clinafloxacin (CI-960, PD 127391, AM-1091) and PD 131628 (the active… Expand A 7H9 broth microdilution method against CI-960, sparfloxacin, WIN57273, ciprofloxacin, norfloxacin, isepamicin, amikacin… Expand CI-960, fleroxacin, lomefloxacin, and temafloxacin were tested against over 100 strains of Neisseria gonorrhoeae. Each organism… Expand The in vitro activities of PD127391 and the new fluorinated-4-quinolone, PD131628, were compared with each other and with five… Expand The in vitro activity of a new quinolone, AM-1091 [7-(3-amino-1-pyrrolidinyl)-8-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro- 4-oxo… Expand The relationship between the chemical structure and epileptogenic activity of quinolones was investigated. When the quinolones… Expand