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Preclinical Pharmacokinetics and General Toxicology of Iodixanol
To document the safety of iodixanol and to assess its pharmacokinetic properties, extensive tests have been performed. Iodixanol was rapidly excreted, mainly via the kidneys, with a plasma half-lifeExpand
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Myocardial heat shock proteins during the development of heart failure.
When cardiomyocytes are exposed to stresses, production of heat shock proteins (HSPs) in the cells is enhanced. Such increase in cellular HSP production is considered to bring about tolerance againstExpand
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Protective effect of heat shock protein 72 on contractile function of perfused failing heart.
The contribution of heat shock protein 72 (HSP72) to the protection of cardiac function was examined in rats with chronic heat failure (CHF) following coronary artery ligation (CAL). The CAL animalsExpand
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Age- and Sex-Related Differences in Spontaneous Hemorrhage and Fibrosis of the Pancreatic Islets in Sprague–Dawley Rats
To elucidate the spontaneous occurrence of hemorrhage in the pancreatic islet, naïve Crj:CD(SD)IGS rats were given a commercially available standard diet ad libitum over 20 weeks, and wereExpand
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Detection of hemotropic mycoplasmas in free-living brown sewer rats (Rattus norvegicus).
The prevalence of hemotropic mycoplasmas in wild rodents is largely unknown. Here, we report the presence of hemoplasmas in blood samples collected from brown sewer rats (Rattus norvegicus) trappedExpand
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The measurement of gastric emptying in conscious rats by monitoring serial changes in serum acetaminophen level.
A method for evaluation of gastric emptying via monitoring serial serum levels of acetaminophen (APAP) as an indicator, without involving animal sacrifice, has been developed in conscious rats. WeExpand
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Pharmacokinetic disposition and arthropathic potential of oral ofloxacin in dogs.
We examined the relation between the pharmacokinetic disposition and arthropathic potential of ofloxacin, a new quinolone antibacterial agent, using both male immature (3-month-old) and matureExpand
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A single-blood-sample method using inulin for estimating feline glomerular filtration rate.
BACKGROUND Application of a multisample method using inulin to estimate glomerular filtration rate (GFR) in cats is cumbersome. OBJECTIVES To establish a simplified procedure to estimate GFR inExpand
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Response of plasma bone markers to a single intramuscular administration of calcitriol in dairy cows.
To elucidate the effects of an exogenous calcitriol (1,25-dihydroxyvitamin D(3)) on plasma bone markers, the formation item osteocalcin (OC), undercarboxylated OC (ucOC) and bone-specific alkalineExpand
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Pharmacokinetics of tolbutamide following intravenous and oral administrations in rats with obstructive jaundice.
The pharmacokinetics of tolbutamide (TB) following intravenous and oral administration was compared between normal rats and rats with experimentally-induced obstructive jaundice (OJ). The plasmaExpand
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