P. Appelbaum

Publications456
h-index70
Citations18,891
Highly Influential Citations660
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Antimicrobial Resistance in Haemophilus influenzae
TLDR
Haemophilus influenzae is a major community-acquired pathogen causing significant morbidity and mortality worldwide, and strains with alterations in penicillin binding proteins, particularly PBP3 (β-lactamase negative ampicillin resistant and β-l lactamase positive amoxicillin-clavulanate resistant), are increasing in prevalence. Expand
The Alexander Project 1998-2000: susceptibility of pathogens isolated from community-acquired respiratory tract infection to commonly used antimicrobial agents.
TLDR
These data demonstrate the continued evolution of and geographical variation in bacterial resistance and highlight the need for appropriate prescribing of antimicrobials in CARTI, using agents with adequate activity, based on local susceptibility profiles and PK/PD parameters. Expand
Comparison of Multiple-Locus Variable-Number Tandem-Repeat Analysis with Pulsed-Field Gel Electrophoresis, spa Typing, and Multilocus Sequence Typing for Clonal Characterization of Staphylococcus…
TLDR
The results suggest that MLVA may be reliable in shorter-term S. aureus epidemiological studies, including analyses of outbreaks and hospital-to-hospital strain transmission events and those performing routine microbiological analyses within medical centers. Expand
Diversity of ampicillin-resistance genes in Haemophilus influenzae in Japan and the United States.
TLDR
Differences in proportions of respective AMP-resistant genes in H. influenzae isolates between the two countries might reflect differences in antibiotic agents ordinarily given to outpatients with community-acquired bacterial infections. Expand
Two New Mechanisms of Macrolide Resistance in Clinical Strains ofStreptococcus pneumoniae from Eastern Europe and North America
TLDR
Twenty strains with unusual ML or MSB phenotypes which did not harbor erm(B) ormef(A) phenotypes were studied and macrolide resistance mechanisms from clinical isolates are similar to those recently described for laboratory-derived mutants. Expand
Diversity of Ribosomal Mutations Conferring Resistance to Macrolides, Clindamycin, Streptogramin, and Telithromycin in Streptococcus pneumoniae
TLDR
Twenty-two macrolide-resistant mutants selected in vitro from 5 parental strains of macrolid-susceptible Streptococcus pneumoniae by serial passage in various macrolides were studied, finding no mutations in L22, L4, or 23S rRNA could be detected. Expand
Antimicrobial resistance in Streptococcus pneumoniae: an overview.
  • P. Appelbaum
  • Medicine
  • Clinical infectious diseases : an official…
  • 1 July 1992
TLDR
Pneumococcal resistance has been described in Zambia, Japan, Malaysia, Pakistan, Bangladesh, Chile, and Brazil; information from other African, Asian, and South American countries is not available. Expand
Mutations in 23S rRNA and Ribosomal Protein L4 Account for Resistance in Pneumococcal Strains Selected In Vitro by Macrolide Passage
TLDR
To the authors' knowledge, this is the first description of mutations in 23S rRNA genes or ribosomal proteins in macrolide-resistant S. pneumoniae strains. Expand
Antistaphylococcal Activity of Ceftobiprole, a New Broad-Spectrum Cephalosporin
TLDR
Ceftobiprole is a novel cephalosporin with expanded activity against gram-positive bacteria and single-passage selections showed very low frequencies of resistance to ceftoiprole irrespective of genotype or phenotype. Expand
Vancomycin-Resistant Staphylococcus aureus Isolate from a Patient in Pennsylvania
TLDR
Pulsed-field gel electrophoresis of SmaI-digested genomic DNA indicated that the isolate belonged to the USA100 lineage (also known as the New York/Japan clone), the most common staphylococcal PFGE type found in hospitals in the United States. Expand
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