• Publications
  • Influence
Development of interpretive breakpoints for antifungal susceptibility testing: conceptual framework and analysis of in vitro-in vivo correlation data for fluconazole, itraconazole, and candida
TLDR
The conceptual framework underlying interpretation of antimicrobial susceptibility testing results is examined and these ideas are used to drive analysis of data packages developed by the respective manufacturers that correlate fluconazole and itraconazole MICs with outcome of candidal infections. Expand
Detection of extended-spectrum-beta-lactamase-producing members of the family Enterobacteriaceae with Vitek ESBL test
TLDR
Data indicate that the Vitek ESBL test is reliable for the detection of ESBLs in E. coli and K. pneumoniae, the two species in which ESBLS are most common, and of hyperproduction of the K. oxytoca beta-lactamase in strains of this species as well. Expand
Fluconazole disk diffusion procedure for determining susceptibility of Candida species
  • A. Barry, S. Brown
  • Medicine, Biology
  • Journal of clinical microbiology
  • 1 September 1996
TLDR
The disk test did not adequately separate fully resistant strains from those with dose-dependent susceptibility: additional quantitative tests are needed for the few that are not unequivocally susceptible by the disk method. Expand
Quality Control Limits for Broth Microdilution Susceptibility Tests of Ten Antifungal Agents
TLDR
An eight-laboratory collaborative study was carried out to document reproducibility of tests of Candida parapsilosis ATCC 22019 and Candida krusei ATCC 6258 by the NCCLS method. Expand
In Vitro Activities of Daptomycin against 2,789 Clinical Isolates from 11 North American Medical Centers
  • A. Barry, P. Fuchs, Steven D. Brown
  • Medicine, Biology
  • Antimicrobial Agents and Chemotherapy
  • 1 June 2001
TLDR
The in vitro activity of daptomycin is affected by the concentration of calcium cations in the test medium, and greater concentrations of calcium (50 mg/liter) are recommended to better resemble the normal concentration of ionized calcium in human serum. Expand
In vitro bactericidal activity of daptomycin against staphylococci.
TLDR
Of the four drugs tested, daptomycin was bactericidal against the most strains and had the most rapid cidal activity. Expand
Rapid determination of antimicrobial susceptibility for urgent clinical situations.
TLDR
Data is presented to show that the conventional approach to susceptibility tests for drugs and bacterial genera is too unreliable for clinical use, especially with specimens containing mixtures of microorganisms. Expand
In Vitro Activities of the Ketolide HMR 3647 against Recent Gram-Positive Clinical Isolates and Haemophilus influenzae
  • A. Barry, P. Fuchs, Steven D. Brown
  • Biology, Medicine
  • Antimicrobial Agents and Chemotherapy
  • 1 August 1998
TLDR
The ketolide HMR 3647 (previously RU 66647) was evaluated against 2,563 recent clinical isolates of gram-positive pathogens and 200Haemophilus influenzae isolates, and was active against macrolide-resistant streptococci, but was not active againstmacrolides- or lincosamide-resistant staphylococci. Expand
Identification of β-Lactamase-Negative, Ampicillin-Resistant Strains of Haemophilus influenzae with Four Methods and Eight Media
  • A. Barry, P. Fuchs, Steven D. Brown
  • Medicine, Biology
  • Antimicrobial Agents and Chemotherapy
  • 1 May 2001
TLDR
The data emphasize the need for a standardized testing procedure and a universal definition of BLNAR strains before the clinical relevance of such strains can be evaluated. Expand
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