androstane-3,17-diol glucuronide

Known as: 3 alpha-diol G, 5-Androstane-3alpha,17beta-Diol Glucuronide, 3-alpha-androstanediol glucuronide 
A glucuronosyltransferase-modified, alcohol-conjugated metabolite of the steroid androsterone and metabolite of the steroid dihydrotestosterone… (More)
National Institutes of Health

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Androstane-3,17-diol
analogs & derivatives

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Highly Cited
2010
Highly Cited
2010
Repeat dose study of the cancer chemopreventive agent resveratrol in healthy volunteers: safety, pharmacokinetics, and effect on the insulin-like growth factor axis.
Resveratrol, a naturally occurring polyphenol, has cancer chemopreventive properties in preclinical models. It has been shown to… (More)
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Highly Cited
2010
Highly Cited
2010
Clinical pharmacology of resveratrol and its metabolites in colorectal cancer patients.
Resveratrol is a phytochemical with chemopreventive activity in preclinical rodent models of colorectal carcinogenesis… (More)
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Highly Cited
2010
Highly Cited
2010
Pharmacokinetics, oral bioavailability, and metabolic profile of resveratrol and its dimethylether analog, pterostilbene, in rats
Resveratrol (3,5,4′-trihydroxy-trans-stilbene) is a naturally occurring polyphenol with a broad range of possible health benefits… (More)
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Highly Cited
2004
Highly Cited
2004
Role of organic anion transporter OATP1B1 (OATP-C) in hepatic uptake of irinotecan and its active metabolite, 7-ethyl-10-hydroxycamptothecin: in vitro evidence and effect of single nucleotide…
Irinotecan hydrochloride (CPT-11) is a potent anticancer drug that is converted to its active metabolite, 7-ethyl-10… (More)
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Highly Cited
2004
Highly Cited
2004
Metabonomic investigations in mice infected with Schistosoma mansoni: an approach for biomarker identification.
Schistosomiasis, a chronic and debilitating parasitic disease, affects approximately 200 million people in the developing world… (More)
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Highly Cited
2002
Highly Cited
2002
Metabolism and kinetics of bisphenol a in humans at low doses following oral administration.
Bisphenol A is a widely used industrial chemical with many potential sources of human exposure. Bisphenol A is a weak estrogen… (More)
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Highly Cited
2002
Highly Cited
2002
UGT1A1*28 polymorphism as a determinant of irinotecan disposition and toxicity
The metabolism of irinotecan (CPT-11) involves sequential activation to SN-38 and detoxification to the pharmacologically… (More)
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Highly Cited
2001
Highly Cited
2001
Characterization of metabolites of the chemopreventive agent curcumin in human and rat hepatocytes and in the rat in vivo, and evaluation of their ability to inhibit phorbol ester-induced…
Curcumin, the yellow pigment in turmeric, has been shown to prevent malignancies in a variety of tissues in rodents, especially… (More)
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Highly Cited
1999
Highly Cited
1999
Ethnic differences in N-glucuronidation of nicotine and cotinine.
We previously reported that the metabolism of cotinine, the proximate metabolite of nicotine, is significantly slower in black… (More)
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Highly Cited
1998
Highly Cited
1998
Differences in the catalytic efficiencies of allelic variants of glutathione transferase P1-1 towards carcinogenic diol epoxides of polycyclic aromatic hydrocarbons.
Previous studies have identified allelic variants of the human glutathione transferase (GST) Pi gene and showed that the two… (More)
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