Elevation of extrahepatic glutathione S-transferase and epoxide hydratase activities by 2(3)-tert-butyl-4-hydroxyanisole.

@article{Benson1979ElevationOE,
  title={Elevation of extrahepatic glutathione S-transferase and epoxide hydratase activities by 2(3)-tert-butyl-4-hydroxyanisole.},
  author={Ann M. Benson and Y N Cha and Ernest Bueding and H S Heine and Paul Talalay},
  journal={Cancer research},
  year={1979},
  volume={39 8},
  pages={2971-7}
}
Investigations in these and other laboratories have estab lished that administration of 2(3)-tert-butyl-4-hydroxyanisole (BHA) to rodents: (a) protects a variety of target tissues against the production of tumors by a wide range of chemical carcin ogens; (b) reduces the levels of mutagenic metabolites pro duced from benzo(a)pyrene and numerous therapeutic agents in viva; (c) elevates the hepatic activities of microsomal epoxide hydratase and cytosol glutathione S-transferase; (d) alters the… CONTINUE READING