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The role of IKK in constitutive activation of NF-kappaB transcription factor in prostate carcinoma cells.
The data suggest that increased IKK activation leads to the constitutive activation of NF-kappaB 'survival signaling' pathway in androgen-independent PC cells, important for the support of their androgens-independent status and growth advantage.
Regulation of connexin 43-mediated gap junctional intercellular communication by Ca2+ in mouse epidermal cells is controlled by E- cadherin
The results suggest that Ca(2+)-dependent regulation of GJIC in mouse epidermal cells is directly controlled by a calcium-dependent cell adhesion molecule, E-cadherin.
Functional roles of Akt signaling in mouse skin tumorigenesis
Evidence is provided that Akt activation is one of the key elements during the different steps of mouse skin tumorigenesis as demonstrated by the rate of appearance, the growth and the histological characteristics of the tumors.
Final Report of the Safety Assessment of Methylisothiazolinone
- Christina L. Burnett, W. Bergfeld, F. A. Andersen
- ChemistryInternational journal of toxicology
- 1 May 2010
The Cosmetic Ingredient Review Expert Panel concluded that there is a threshold dose response and that cosmetic products formulated to contain concentrations of MIT at 100 ppm (0.01%) or less would not be expected to pose a sensitization risk.
Studies on the mechanism of skin tumor promotion: evidence for several stages in promotion.
- T. Slaga, S. Fischer, K. Nelson, G. Gleason
- BiologyProceedings of the National Academy of Sciences…
- 1 June 1980
Although mezerein by itself is a weak promoter and mimics TPA in many biochemical and morphological effects it is a potent second-stage promoter in a two-stage promotion regimen, the results suggest that 4-O-methyl-TPA had weak activity as a first-stage promoters.
Evidence that the centrally and peripherally located cells in the murine epidermal proliferative unit are two distinct cell populations.
2 classes of epidermal basal cells have different early responses to TPA treatment: the label-retaining cells proliferate, and most of the "maturing" cells continue to differentiate.
Mechanism-based cancer prevention approaches: targets, examples, and the use of transgenic mice.
- S. Hursting, T. Slaga, S. Fischer, J. DiGiovanni, J. Phang
- Biology, MedicineJournal of the National Cancer Institute
- 3 February 1999
The utility for mechanism-based cancer prevention research of new animal models that are based on the overexpression or inactivation of specific cancer-related genes is examined and the purposes of this review are examined.
Eugenol Causes Melanoma Growth Suppression through Inhibition of E2F1 Transcriptional Activity*
- R. Ghosh, N. Nadiminty, J. Fitzpatrick, W. Alworth, T. Slaga, Addanki P. Kumar
- BiologyJournal of Biological Chemistry
- 18 February 2005
Examination of the mechanism of the antiproliferative action of eugenol in the human malignant melanoma cell line, WM1205Lu, showed that it arrests cells in the S phase of the cell cycle, suggesting that eugenols could be developed as an E2F-targeted agent for melanoma treatment.
Phorbol esters stimulate DNA synthesis and ornithine decarboxylase activity in mouse epidermal cell cultures
Evidence from the laboratory indicates that brief exposure to the potent phorbol ester 12-O-tetradecanoyl-phorbol-13-acetate (TPA), stimulates DNA synthesis and ODC activity in mouse epidermal cell cultures.
The hamster cheek pouch carcinogenesis model
The Syrian golden hamster cheek pouch carcinogenesis model is probably the best‐known animal system that closely compares to events involved in the development of premalignant and malignant human oral cancers and a two‐stage carcinogenesis protocol is established, confirming that this mutation in codon 61 of the Ha‐ras gene is initiation‐related.