Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors.
- T. Chou, P. Talalay
- BiologyAdvances in Enzyme Regulation
- 1984
The chemical diversity and distribution of glucosinolates and isothiocyanates among plants.
- J. Fahey, A. T. Zalcmann, P. Talalay
- Biology, MedicinePhytochemistry
- 2001
Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants
- A. Dinkova-Kostova, W. D. Holtzclaw, P. Talalay
- Chemistry, BiologyProceedings of the National Academy of Sciences…
- 22 August 2002
This finding suggests that reaction of cysteine thiols is followed by rapid formation of protein disulfide linkages, which are the direct sensors of inducers of the phase 2 system.
A major inducer of anticarcinogenic protective enzymes from broccoli: isolation and elucidation of structure.
- Y. Zhang, P. Talalay, C. Cho, G. Posner
- Biology, ChemistryProceedings of the National Academy of Sciences…
- 15 March 1992
Sulforaphane is the most potent inducer, and the presence of oxygen on sulfur enhances potency, which may be a significant component of the anticarcinogenic action of broccoli.
Protection against electrophile and oxidant stress by induction of the phase 2 response: Fate of cysteines of the Keap1 sensor modified by inducers
- N. Wakabayashi, A. Dinkova-Kostova, P. Talalay
- BiologyProceedings of the National Academy of Sciences…
- 5 February 2004
Evidence for formation of intermolecular disulfide bridges was obtained by 2D PAGE of extracts of cells treated with inducers, and by the demonstration that whereas C273A and C288A mutants of Keap1 alone could not repress Nrf2 activation of the ARE-luciferase reporter, an equal mixture of these mutant constructs restored repressor activity.
Generalized equations for the analysis of inhibitions of Michaelis-Menten and higher-order kinetic systems with two or more mutually exclusive and nonexclusive inhibitors.
- T. Chou, P. Talalay
- BiologyEuropean Journal of Biochemistry
- 3 March 2005
The following simple and generalized equation describes the summation of the effects of two mutually exclusive and reversible inhibitors on enzyme systems obeying Michaelis-Menten kinetics, which has been extended to higher-order (Hill-type) systems in which each reversible inhibitor has more than one binding site.
Broccoli sprouts: an exceptionally rich source of inducers of enzymes that protect against chemical carcinogens.
- J. Fahey, Y. Zhang, P. Talalay
- Chemistry, MedicineProceedings of the National Academy of Sciences…
- 16 September 1997
Induction of phase 2 detoxication enzymes [e.g., glutathione transferases, epoxide hydrolase, NAD(P)H: quinone reductase, and glucuronosyltransferases] is a powerful strategy for achieving protection…
Human metabolism and excretion of cancer chemoprotective glucosinolates and isothiocyanates of cruciferous vegetables.
- T. Shapiro, J. Fahey, K. Wade, K. Stephenson, P. Talalay
- ChemistryCancer Epidemiology, Biomarkers and Prevention
- 1 December 1998
It is established that humans convert substantial amounts of isothiocyanates and glucosinolates to urinary dithiocarbamates that can be easily quantified, thus paving the way for meaningful studies of phase 2 enzyme induction in humans.
NAD(P)H:quinone acceptor oxidoreductase 1 (NQO1), a multifunctional antioxidant enzyme and exceptionally versatile cytoprotector.
- A. Dinkova-Kostova, P. Talalay
- Biology, ChemistryArchives of Biochemistry and Biophysics
- 1 September 2010
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