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Functional role of estrogen metabolism in target cells: review and perspectives.
Some of the many actions of estradiol may not be caused by est radiol per se, but may result from the formation of active estrogen metabolite(s) which function as local mediators or may activate their own unique receptors or effectors.
Induction of microsomal enzymes by foreign chemicals and carcinogenesis by polycyclic aromatic hydrocarbons: G. H. A. Clowes Memorial Lecture.
- A. Conney
- MedicineCancer research
- 1 December 1982
An important problem that has been of great interest to me for many years is individuality in the response of human beings and other living organisms to foreign chemicals.
Characterization of the oxidative metabolites of 17beta-estradiol and estrone formed by 15 selectively expressed human cytochrome p450 isoforms.
Many human CYP isoforms are involved in the oxidative metabolism of 17beta-estradiol and estrone, with a varying degree of catalytic activity and distinct regioselectivity.
Pharmacological implications of microsomal enzyme induction.
- A. Conney
- Biology, MedicinePharmacological reviews
- 1 September 1967
It is of considerable interest that certain inducers of liver microsomal enzymes have recently been used therapeutically for the treatment of hyperbilirubinemia in jaundiced children and for thetreatment of Cushing's syndrome.
Environmental and chemical carcinogenesis.
Is 2-methoxyestradiol an endogenous estrogen metabolite that inhibits mammary carcinogenesis?
Recent studies on the antitumorigenic and antiangiogenic effects of exogenously administered 2-methoxyestradiol in vitro and in vivo are reviewed and it is suggested that some unique effects of 2-MethoxyESTradiol may be mediated by a specific intracellular effector or receptor that is refractory to the parent hormone, estradiol.
Inhibitory effects of dietary curcumin on forestomach, duodenal, and colon carcinogenesis in mice.
- M. Huang, Y. Lou, W. Ma, H. Newmark, K. Reuhl, A. Conney
- Biology, MedicineCancer research
- 15 November 1994
Results indicate that not only did curcumin inhibit the number of tumors per mouse and the percentage of mice with tumors but it also reduced tumor size.
Inhibition of skin tumorigenesis by rosemary and its constituents carnosol and ursolic acid.
Topical application of carnosol or ursolic acid isolated from rosemary inhibited TPA-induced ear inflammation, ornithine decarboxylase activity, and tumor promotion and applied to mice previously initiated with DMBA inhibited the number of skin tumors per mouse.
Inhibitory effect of curcumin, chlorogenic acid, caffeic acid, and ferulic acid on tumor promotion in mouse skin by 12-O-tetradecanoylphorbol-13-acetate.
The effects of topically applied curcumin, chlorogenic acid, caffeic acid, and ferulic acid on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced epidermal ornithine decarboxylase activity, epidermal…
Inhibitory effects of curcumin on in vitro lipoxygenase and cyclooxygenase activities in mouse epidermis.
- M. Huang, T. Lysz, T. Ferraro, T. F. Abidi, J. Laskin, A. Conney
- Biology, ChemistryCancer research
- 1 February 1991
The inhibitory effects of curcumin, chlorogenic acid, caffeic acid, and ferulic acid on TPA-induced tumor promotion in mouse epidermis parallel their inhibitory effect on T PA-induced epidermal inflammation and epider mal lipoxygenase and cyclo oxygengenase activities.