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  • Influence
Functional role of estrogen metabolism in target cells: review and perspectives.
Some of the many actions of estradiol may not be caused by est radiol per se, but may result from the formation of active estrogen metabolite(s) which function as local mediators or may activate their own unique receptors or effectors. Expand
Characterization of the oxidative metabolites of 17beta-estradiol and estrone formed by 15 selectively expressed human cytochrome p450 isoforms.
Many human CYP isoforms are involved in the oxidative metabolism of 17beta-estradiol and estrone, with a varying degree of catalytic activity and distinct regioselectivity. Expand
Pharmacological implications of microsomal enzyme induction.
  • A. Conney
  • Biology, Medicine
  • Pharmacological reviews
  • 1 September 1967
It is of considerable interest that certain inducers of liver microsomal enzymes have recently been used therapeutically for the treatment of hyperbilirubinemia in jaundiced children and for thetreatment of Cushing's syndrome. Expand
Induction of microsomal enzymes by foreign chemicals and carcinogenesis by polycyclic aromatic hydrocarbons: G. H. A. Clowes Memorial Lecture.
  • A. Conney
  • Medicine
  • Cancer research
  • 1 December 1982
An important problem that has been of great interest to me for many years is individuality in the response of human beings and other living organisms to foreign chemicals. Expand
Environmental and chemical carcinogenesis.
This chapter summarizes several aspects of environmental chemical carcinogenesis that have been extensively studied and illustrates the power of mechanistic investigation combined with molecular epidemiologic approaches in establishing causative linkages between environmental exposures and increased cancer risks. Expand
Is 2-methoxyestradiol an endogenous estrogen metabolite that inhibits mammary carcinogenesis?
Recent studies on the antitumorigenic and antiangiogenic effects of exogenously administered 2-methoxyestradiol in vitro and in vivo are reviewed and it is suggested that some unique effects of 2-MethoxyESTradiol may be mediated by a specific intracellular effector or receptor that is refractory to the parent hormone, estradiol. Expand
Inhibitory effects of dietary curcumin on forestomach, duodenal, and colon carcinogenesis in mice.
Results indicate that not only did curcumin inhibit the number of tumors per mouse and the percentage of mice with tumors but it also reduced tumor size. Expand
Inhibition of 7,12-dimethylbenz(a)anthracene-induced skin tumorigenesis in C57BL/6 mice by sulforaphane is mediated by nuclear factor E2-related factor 2.
The results show for the first time that Nrf2(-/-) mice are more susceptible to skin tumorigenesis and that the chemopreventive effects of sulforaphane are mediated, at least in part, through NRF2. Expand
Inhibitory effects of curcumin on in vitro lipoxygenase and cyclooxygenase activities in mouse epidermis.
The inhibitory effects of curcumin, chlorogenic acid, caffeic acid, and ferulic acid on TPA-induced tumor promotion in mouse epidermis parallel their inhibitory effect on T PA-induced epidermal inflammation and epider mal lipoxygenase and cyclo oxygengenase activities. Expand
Inhibition of skin tumorigenesis by rosemary and its constituents carnosol and ursolic acid.
Topical application of carnosol or ursolic acid isolated from rosemary inhibited TPA-induced ear inflammation, ornithine decarboxylase activity, and tumor promotion and applied to mice previously initiated with DMBA inhibited the number of skin tumors per mouse. Expand