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HLA-E surface expression depends on binding of TAP-dependent peptides derived from certain HLA class I signal sequences.
Analysis of peptides bound to HLA-E revealed that a nonamer peptide derived from the A2 signal sequence was the predominant peptide bound, and was nearly identical to the leader sequence-derived peptide previously shown to be a predominant Peptide bound to the murine Qa-1 Ag. Expand
Cloning, mapping, and characterization of activated leukocyte-cell adhesion molecule (ALCAM), a CD6 ligand
It is reported that CD6 expressed by COS cells mediates adhesion to TE cells and that this interaction is specifically blocked with an anti-CD6 monoclonal antibody (mAb) or with a mAb that recognized a TE cell antigen. Expand
Protein Expression and Peptide Binding Suggest Unique and Interacting Functional Roles for HLA-E, F, and G in Maternal-Placental Immune Recognition 1
The structure and expression of the HLA-E, F, and G class I complexes in placental tissue were focused on and a restricted pattern of expression was observed, primarily on extravillous trophoblasts that had invaded the maternal decidua. Expand
The membrane-bound and soluble forms of HLA-G bind identical sets of endogenous peptides but differ with respect to TAP association.
The results show that, similar to classical class I proteins, the membrane-bound form of HLA-G associated with TAP, as evidenced by the ability to immunoprecipitate Hla-G class I heavy chain with T AP antisera. Expand
Rat transforming growth factor type 1: structure and relation to epidermal growth factor.
The complete amino acid sequence of rat transforming growth factor type 1 has been determined. This growth factor, obtained from retrovirus-transformed fibroblasts, is structurally and functionallyExpand
Oncostatin M: a growth regulator produced by differentiated histiocytic lymphoma cells.
A polypeptide termed oncostatin M, which inhibits the replication of A375 melanoma and other human tumor cells, but not normal human fibroblasts, has been isolated from serum-free supernatants ofExpand
The Amino-terminal Immunoglobulin-like Domain of Activated Leukocyte Cell Adhesion Molecule Binds Specifically to the Membrane-proximal Scavenger Receptor Cysteine-rich Domain of CD6 with a 1:1
The stoichiometry of the interaction between the amino-terminal ALCAM domains and the membrane-proximal CD6 SRCR domain is 1:1, providing the first example of an Ig-like domain mediating an interaction with an SRCr domain. Expand
Transforming growth factors produced by retrovirus-transformed rodent fibroblasts and human melanoma cells: amino acid sequence homology with epidermal growth factor.
The reported results suggest that TGFs that compete for binding to the cellular EGF receptor and EGF may have evolved from a common progenitor. Expand
Site-directed mutagenesis of cysteine residues in the pro region of the transforming growth factor beta 1 precursor. Expression and characterization of mutant proteins.
Analysis of recombinant proteins by immunoblotting showed that by substituting Cys-33 the 90-110-kDa protein is not formed, and thus, more mature dimer is obtained, corresponding to a 3- to 5-fold increase in biological activity. Expand
Transformation induced by Abelson murine leukemia virus involves production of a polypeptide growth factor.
Rat embryo fibroblasts transformed by Abelson murine leukemia virus produce and release a transforming growth factor (TGF), which is correlated with a tyrosine-specific protein kinase that is functionally active and is associated with the major Abelson MuLV gene product, P120. Expand