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Transforming Growth Factors

Known as: Factor, Transforming Growth, Growth Factor, Transforming, TGF 
Hormonally active polypeptides that can induce the transformed phenotype when added to normal, non-transformed cells. They have been found in culture… Expand
National Institutes of Health

Related topics

Related topics

43 relations
Artemin, humanBMP2 protein, humanBMP3 protein, humanBMP5 protein, human
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Narrower (7)

Bone Morphogenetic ProteinsTransforming Growth Factor Beta 2Transforming Growth Factor alphaTransforming Growth Factor beta
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Broader (1)

Growth Substances

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2001
Highly Cited
2001
Cell Contact–Dependent Immunosuppression by Cd4+Cd25+Regulatory T Cells Is Mediated by Cell Surface–Bound Transforming Growth Factor β
CD4+CD25+ T cells have been identified as a population of immunoregulatory T cells, which mediate suppression of CD4+CD25− T… Expand
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Review
2000
Review
2000
Role of transforming growth factor beta in human disease.
In human tissues, normal homeostasis requires intricately balanced interactions between cells and the network of secreted… Expand
Highly Cited
1994
Highly Cited
1994
p27Kip1, a cyclin-Cdk inhibitor, links transforming growth factor-beta and contact inhibition to cell cycle arrest.
Cell-cell contact and TGF-beta can arrest the cell cycle in G1. Mv1Lu mink epithelial cells arrested by either mechanism are… Expand
Highly Cited
1993
Highly Cited
1993
Transforming growth factor beta 1 null mutation in mice causes excessive inflammatory response and early death.
To delineate specific developmental roles of transforming growth factor beta 1 (TGF-beta 1) we have disrupted its cognate gene in… Expand
Highly Cited
1993
Highly Cited
1993
Transforming growth factor-beta 1 induces alpha-smooth muscle actin expression in granulation tissue myofibroblasts and in quiescent and growing cultured fibroblasts
Granulation tissue fibroblasts (myofibroblasts) develop several ultrastructural and biochemical features of smooth muscle (SM… Expand
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Review
1990
Review
1990
The transforming growth factor-beta family.
  • J. Massagué
  • Annual review of cell biology
  • 1990
    • Corpus ID: 35109826
Highly Cited
1987
Highly Cited
1987
Transforming growth factor type beta induces monocyte chemotaxis and growth factor production.
  • S. Wahl, D. Hunt, +4 authors M. Sporn
  • Proceedings of the National Academy of Sciences…
  • 1987
    • Corpus ID: 29724321
Recent studies have focused on the potential role of transforming growth factor type beta (TGF-beta) as an immunoregulatory… Expand
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Highly Cited
1986
Highly Cited
1986
Transforming growth factor-beta stimulates the expression of fibronectin and collagen and their incorporation into the extracellular matrix.
We have examined whether the extracellular matrix is a biochemical target for transforming growth factor-beta (TGFbeta). We find… Expand
Highly Cited
1983
Highly Cited
1983
Transforming growth factor-beta in human platelets. Identification of a major storage site, purification, and characterization.
Acidic ethanol extracts of human platelets induced non-neoplastic normal rat kidney fibroblasts to undergo anchorage-independent… Expand
Highly Cited
1981
Highly Cited
1981
New class of transforming growth factors potentiated by epidermal growth factor: isolation from non-neoplastic tissues.
Proteins potentiated by epidermal growth factor (EGF) to induce a transformed phenotype in non-neoplastic rat kidney fibroblasts… Expand
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