Transforming Growth Factors

Known as: Factor, Transforming Growth, Growth Factor, Transforming, TGF 
Hormonally active polypeptides that can induce the transformed phenotype when added to normal, non-transformed cells. They have been found in culture… (More)
National Institutes of Health

Related topics

Related topics

43 relations
Artemin, humanBMP2 protein, humanBMP3 protein, humanBMP5 protein, human
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Narrower (7)

Bone Morphogenetic ProteinsTransforming Growth Factor Beta 2Transforming Growth Factor alphaTransforming Growth Factor beta
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Broader (1)

Growth Substances

Papers overview

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Highly Cited
2007
Highly Cited
2007
Interleukins 1beta and 6 but not transforming growth factor-beta are essential for the differentiation of interleukin 17-producing human T helper cells.
Interleukin 17 (IL-17)-producing CD4(+) helper T cells (T(H)-17 cells) have been linked to host defense and autoimmune diseases… (More)
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Highly Cited
2002
Highly Cited
2002
SB-431542 is a potent and specific inhibitor of transforming growth factor-beta superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7.
Small molecule inhibitors have proven extremely useful for investigating signal transduction pathways and have the potential for… (More)
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Highly Cited
2001
Highly Cited
2001
Cell Contact–Dependent Immunosuppression by Cd4+Cd25+Regulatory T Cells Is Mediated by Cell Surface–Bound Transforming Growth Factor β
CD4(+)CD25(+) T cells have been identified as a population of immunoregulatory T cells, which mediate suppression of CD4(+)CD25… (More)
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Highly Cited
2001
Highly Cited
2001
Induction and mechanism of action of transforming growth factor-beta-secreting Th3 regulatory cells.
Th3 CD4+ regulatory cells were identified during the course of investigating mechanisms associated with oral tolerance. Different… (More)
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Highly Cited
2000
Highly Cited
2000
Phosphatidylinositol 3-kinase function is required for transforming growth factor beta-mediated epithelial to mesenchymal transition and cell migration.
We have studied the role of phosphatidylinositol 3-OH kinase (PI3K)-Akt signaling in transforming growth factor beta (TGFbeta… (More)
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Highly Cited
1998
Highly Cited
1998
Platelet-rich plasma: Growth factor enhancement for bone grafts.
Platelet-rich plasma is an autologous source of platelet-derived growth factor and transforming growth factor beta that is… (More)
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Highly Cited
1994
Highly Cited
1994
p27Kip1, a cyclin-Cdk inhibitor, links transforming growth factor-beta and contact inhibition to cell cycle arrest.
Cell-cell contact and TGF-beta can arrest the cell cycle in G1. Mv1Lu mink epithelial cells arrested by either mechanism are… (More)
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Highly Cited
1993
Highly Cited
1993
Transforming growth factor beta 1 null mutation in mice causes excessive inflammatory response and early death.
To delineate specific developmental roles of transforming growth factor beta 1 (TGF-beta 1) we have disrupted its cognate gene in… (More)
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Review
1987
Review
1987
Angiogenic factors.
Within the past 2 years, several angiogenic factors have been fully purified, their amino acid sequences determined, and their… (More)
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Highly Cited
1986
Highly Cited
1986
Transforming growth factor-beta stimulates the expression of fibronectin and collagen and their incorporation into the extracellular matrix.
We have examined whether the extracellular matrix is a biochemical target for transforming growth factor-beta (TGFbeta). We find… (More)
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