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Transforming growth factor type beta: rapid induction of fibrosis and angiogenesis in vivo and stimulation of collagen formation in vitro.
Further data are obtained to support a role for TGF-beta as an intrinsic mediator of collagen formation: conditioned media obtained from activated human tonsillar T lymphocytes contain greatly elevated levels of T GF-beta compared tomedia obtained from unactivated lymphocytes. Expand
Transforming growth factor beta 1 null mutation in mice causes excessive inflammatory response and early death.
Pathological examination revealed an excessive inflammatory response with massive infiltration of lymphocytes and macrophages in many organs, but primarily in heart and lungs, which suggests a prominent role for TGF-beta 1 in homeostatic regulation of immune cell proliferation and extravasation into tissues. Expand
NRF2 and cancer: the good, the bad and the importance of context
This Opinion article aims to rationalize conflicting perspectives by critiquing the context dependence of NRF2 functions and the experimental methods behind these conflicting data. Expand
The Retinoids : biology, chemistry, and medicine
lntroduction Michael B. Sporn and Anita B. Roberts The Synthetic Chemistry of Retinoids Marcia I. Dawson and Peter D. Hobbs Retinoid Skeletal-Bond Methodology / Methodology for Constructing the PolarExpand
Production of transforming growth factor beta by human T lymphocytes and its potential role in the regulation of T cell growth
TGF-beta may be an important antigen-nonspecific regulator of human T cell proliferation, and important in T cell interaction with other cell types whose cellular functions are modulated by TGF- beta. Expand
Triterpenoids and rexinoids as multifunctional agents for the prevention and treatment of cancer
Synthetic oleanane triterpenoids and rexinoids are two new classes of multifunctional drugs that have unique molecular and cellular mechanisms of action and might prove to be synergistic with standard anti-cancer treatments. Expand
Transforming growth factor-beta in human platelets. Identification of a major storage site, purification, and characterization.
The results show that platelets contain a type beta transforming growth factor, which is distinct from platelet-derived growth factor and elicits 50% of its maximal biological response at concentrations less than 5 x 10(-12) M. Expand
Human transforming growth factor-β complementary DNA sequence and expression in normal and transformed cells
The cDNA sequence indicates that the 112-amino acid monomeric form of the natural TGF-β homodimer is derived proteolytically from a much longer precursor polypeptide which may be secreted. Expand
Some recent advances in the chemistry and biology of transforming growth factor-beta
It is clear that there is no one principal action for TGF-beta; moreover, the almost universal cellular distribution of its receptor encompasses a very broad spectrum of target tissues. Expand
New class of transforming growth factors potentiated by epidermal growth factor: isolation from non-neoplastic tissues.
Proteins potentiated by epidermal growth factor (EGF) to induce a transformed phenotype in non-neoplastic rat kidney fibroblasts in cell culture have been isolated from many non-neoplastic tissues ofExpand