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Endothelial-to-mesenchymal transition contributes to cardiac fibrosis
Cardiac fibrosis, associated with a decreased extent of microvasculature and with disruption of normal myocardial structures, results from excessive deposition of extracellular matrix, which isExpand
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Transforming growth factor type beta: rapid induction of fibrosis and angiogenesis in vivo and stimulation of collagen formation in vitro.
Transforming growth factor type beta (TGF-beta), when injected subcutaneously in newborn mice, causes formation of granulation tissue (induction of angiogenesis and activation of fibroblasts toExpand
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The Retinoids : biology, chemistry, and medicine
lntroduction Michael B. Sporn and Anita B. Roberts The Synthetic Chemistry of Retinoids Marcia I. Dawson and Peter D. Hobbs Retinoid Skeletal-Bond Methodology / Methodology for Constructing the PolarExpand
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Mice lacking Smad3 show accelerated wound healing and an impaired local inflammatory response
The generation of animals lacking SMAD proteins, which transduce signals from transforming growth factor-β (TGF-β), has made it possible to explore the contribution of the SMAD proteins to TGF-βExpand
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Smad3 is key to TGF-beta-mediated epithelial-to-mesenchymal transition, fibrosis, tumor suppression and metastasis.
Smads2 and 3 transduce signals of TGF-beta from the cell surface to the nucleus. We used mice with a targeted deletion of Smad3 to study the specific contributions of this signaling pathway toExpand
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Targeted disruption of TGF-beta1/Smad3 signaling protects against renal tubulointerstitial fibrosis induced by unilateral ureteral obstruction.
Tubulointerstitial fibrosis is the final common result of a variety of progressive injuries leading to chronic renal failure. Transforming growth factor-beta (TGF-beta) is reportedly upregulated inExpand
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Transforming growth factor beta 1 null mutation in mice causes excessive inflammatory response and early death.
To delineate specific developmental roles of transforming growth factor beta 1 (TGF-beta 1) we have disrupted its cognate gene in mouse embryonic stem cells by homologous recombination to generateExpand
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REGULATION OF IMMUNE RESPONSES BY TGF-β*
▪ Abstract The transforming growth factor β (TGF-β) family of proteins are a set of pleiotropic secreted signaling molecules with unique and potent immunoregulatory properties. TGF-β1 is produced byExpand
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Production of transforming growth factor beta by human T lymphocytes and its potential role in the regulation of T cell growth
This study examines the potential role of transforming growth factor beta (TGF-beta) in the regulation of human T lymphocyte proliferation, and proposes that TGF-beta is an important autoregulatoryExpand
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Human transforming growth factor-β complementary DNA sequence and expression in normal and transformed cells
The partial amino-acid sequence of purified human transforming growth factor-β (TGF-β) was used to identify a series of cDNA clones encoding the protein. The cDNA sequence indicates that theExpand
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