Transforming Growth Factor alpha

Known as: Transforming Growth Factor alpha [Chemical/Ingredient], transforming growth factor alpha (TGF alpha), TGFalpha 
An EPIDERMAL GROWTH FACTOR related protein that is found in a variety of tissues including EPITHELIUM, and maternal DECIDUA. It is synthesized as a… (More)
National Institutes of Health

Related topics

Related topics

16 relations
In BloodProcess of secretionTGFA geneagonists
(More)

Narrower (5)

Shope fibroma virus growth factorTGFA protein, humantransforming growth factor alpha-Pseudomonas exotoxin A (40)transforming growth factor(alpha)-Pseudomonas aeruginosa exotoxin (38)
(More)

Broader (1)

Transforming Growth Factors

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2002
Highly Cited
2002
Crystal Structure of a Truncated Epidermal Growth Factor Receptor Extracellular Domain Bound to Transforming Growth Factor α
We report the crystal structure, at 2.5 A resolution, of a truncated human EGFR ectodomain bound to TGFalpha. TGFalpha interacts… (More)
  • table 1
  • figure 1
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
2000
Highly Cited
2000
Cross-talk between epidermal growth factor receptor and c-Met signal pathways in transformed cells.
In rat liver epithelial cells constitutively expressing transforming growth factor alpha (TGFalpha), c-Met is constitutively… (More)
Is this relevant?
Highly Cited
1999
Highly Cited
1999
Expansion of Pdx1-expressing pancreatic epithelium and islet neogenesis in transgenic mice overexpressing transforming growth factor alpha.
BACKGROUND & AIMS The progenitor cells responsible for transforming growth factor (TGF)-alpha-induced pancreatic ductal… (More)
Is this relevant?
Highly Cited
1999
Highly Cited
1999
Radiation-induced release of transforming growth factor alpha activates the epidermal growth factor receptor and mitogen-activated protein kinase pathway in carcinoma cells, leading to increased…
Exposure of A431 squamous and MDA-MB-231 mammary carcinoma cells to ionizing radiation has been associated with short transient… (More)
Is this relevant?
Highly Cited
1998
Highly Cited
1998
Transforming growth factor alpha is a target for the von Hippel-Lindau tumor suppressor.
The von Hippel-Lindau (VHL) tumor suppressor gene has a critical role in the pathogenesis of clear cell renal cell carcinoma (RCC… (More)
Is this relevant?
Highly Cited
1998
Highly Cited
1998
An essential role for ectodomain shedding in mammalian development.
The ectodomains of numerous proteins are released from cells by proteolysis to yield soluble intercellular regulators. The… (More)
Is this relevant?
Highly Cited
1997
Highly Cited
1997
Transforming growth factor-alpha null and senescent mice show decreased neural progenitor cell proliferation in the forebrain subependyma.
The adult mammalian forebrain subependyma contains neural stem cells and their progeny, the constitutively proliferating… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
1997
Highly Cited
1997
Transforming growth factor-alpha-induced transcriptional activation of the vascular permeability factor (VPF/VEGF) gene requires AP-2-dependent DNA binding and transactivation.
The endothelial cell-specific mitogen vascular permeability factor/vascular endothelial growth factor (VPF/VEGF) represents a… (More)
Is this relevant?
Highly Cited
1993
Highly Cited
1993
Elevated levels of transforming growth factor alpha and epidermal growth factor receptor messenger RNA are early markers of carcinogenesis in head and neck cancer.
The squamous mucosa of patients who develop head and neck cancer is "condemned" or predisposed to disregulated growth as… (More)
Is this relevant?
Highly Cited
1987
Highly Cited
1987
Synthesis of messenger RNAs for transforming growth factors alpha and beta and the epidermal growth factor receptor by human tumors.
Human tumors and tumor cell lines were analyzed for the presence of mRNA coding for transforming growth factors alpha and beta… (More)
Is this relevant?