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Transforming Growth Factor alpha

Known as: Transforming Growth Factor alpha [Chemical/Ingredient], transforming growth factor alpha (TGF alpha), TGFalpha 
An EPIDERMAL GROWTH FACTOR related protein that is found in a variety of tissues including EPITHELIUM, and maternal DECIDUA. It is synthesized as a… 
National Institutes of Health

Related topics

Related topics

17 relations
In BloodProcess of secretionTGFA geneTransforming growth factor alpha Ag:PrThr:Pt:Tiss:Ord:Immune stain

Narrower (5)

Shope fibroma virus growth factorTGFA protein, humantransforming growth factor alpha-Pseudomonas exotoxin A (40)transforming growth factor(alpha)-Pseudomonas aeruginosa exotoxin (38)

Broader (1)

Transforming Growth Factors

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2002
Highly Cited
2002
Activation of the MAPK pathway enhances sensitivity of MCF-7 breast cancer cells to the mitogenic effect of estradiol.
Long-term estrogen deprivation causes human breast cancer cells to develop hypersensitivity to the mitogenic effect of estradiol… 
Highly Cited
2001
Highly Cited
2001
Role of leptin in ulcer healing.
Highly Cited
2000
Highly Cited
2000
Morphologic and functional determinants of primordial and primary follicles in the monkey ovary
Highly Cited
1999
Highly Cited
1999
Some hypothalamic hamartomas contain transforming growth factor alpha, a puberty-inducing growth factor, but not luteinizing hormone-releasing hormone neurons.
Activation of LH-releasing hormone (LHRH) secretion, essential for the initiation of puberty, is brought about by the interaction… 
Highly Cited
1997
Highly Cited
1997
Transforming growth factor-alpha enhances cyclin D1 transcription through the binding of early growth response protein to a cis-regulatory element in the cyclin D1 promoter.
Cyclin D1 is a critical oncogene involved in the regulation of progression through the G1 phase of the cell cycle, thereby… 
Highly Cited
1996
Highly Cited
1996
Conditioned medium from a rat ureteric bud cell line in combination with bFGF induces complete differentiation of isolated metanephric mesenchyme.
Differentiation of metanephric mesenchyme is triggered by an inductive signal(s) from the epithelial ureteric bud. As a result of… 
Highly Cited
1991
Highly Cited
1991
Transforming growth factor alpha contributes to the mechanism by which hypothalamic injury induces precocious puberty.
It has long been known that lesions of the hypothalamus lead to female sexual precocity. While an increased production of… 
Highly Cited
1991
Highly Cited
1991
EGF and TGF alpha influence in vitro lung development by the induction of matrix-degrading metalloproteinases.
Remodeling of the extracellular matrix by matrix-degrading metalloproteinases (MMPs) has been implicated in the early… 
Highly Cited
1988
Highly Cited
1988
Blockade of the epidermal growth factor receptor inhibits transforming growth factor alpha-induced but not estrogen-induced growth of hormone-dependent human breast cancer.
Transforming growth factor alpha (TGF alpha), a polypeptide that binds to the epidermal growth factor (EGF) receptor, is… 
Highly Cited
1987
Highly Cited
1987
Expression of transforming growth factor alpha (TGF alpha) in differentiated rat mammary tumors: estrogen induction of TGF alpha production.
Primary well-differentiated dimethylbenzene alpha-anthracene (DMBA)-or nitrosomethylurea (NMU)-induced rat mammary… 
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