Transforming Growth Factor alpha
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We report the crystal structure, at 2.5 A resolution, of a truncated human EGFR ectodomain bound to TGFalpha. TGFalpha interacts… Expand The polytopic membrane protein Rhomboid-1 promotes the cleavage of the membrane-anchored TGFalpha-like growth factor Spitz… Expand Goblet-cell hyperplasia is a critical pathological feature in hypersecretory diseases of airways. However, the underlying… Expand Targeted mice lacking functional EGF or amphiregulin (AR) were derived and bred to the TGFalpha-knockout to generate mice lacking… Expand Exposure of A431 squamous and MDA-MB-231 mammary carcinoma cells to ionizing radiation has been associated with short transient… Expand The ectodomains of numerous proteins are released from cells by proteolysis to yield soluble intercellular regulators. The… Expand The adult mammalian forebrain subependyma contains neural stem cells and their progeny, the constitutively proliferating… Expand The squamous mucosa of patients who develop head and neck cancer is "condemned" or predisposed to disregulated growth as… Expand We investigated whether transforming growth factor alpha (TGF-alpha) is involved in hepatocyte growth responses both in vivo and… Expand Epidermal regeneration following middermal injuries to skin requires both proliferation and migration of keratinocytes. Epidermal… Expand