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Transforming Growth Factor alpha

Known as: Transforming Growth Factor alpha [Chemical/Ingredient], transforming growth factor alpha (TGF alpha), TGFalpha 
An EPIDERMAL GROWTH FACTOR related protein that is found in a variety of tissues including EPITHELIUM, and maternal DECIDUA. It is synthesized as a… Expand
National Institutes of Health

Related topics

Related topics

17 relations
In BloodProcess of secretionTGFA geneTransforming growth factor alpha Ag:PrThr:Pt:Tiss:Ord:Immune stain
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Narrower (5)

Shope fibroma virus growth factorTGFA protein, humantransforming growth factor alpha-Pseudomonas exotoxin A (40)transforming growth factor(alpha)-Pseudomonas aeruginosa exotoxin (38)
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Broader (1)

Transforming Growth Factors

Papers overview

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Highly Cited
2002
Highly Cited
2002
Crystal Structure of a Truncated Epidermal Growth Factor Receptor Extracellular Domain Bound to Transforming Growth Factor α
We report the crystal structure, at 2.5 A resolution, of a truncated human EGFR ectodomain bound to TGFalpha. TGFalpha interacts… Expand
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Highly Cited
2001
Highly Cited
2001
Drosophila Rhomboid-1 Defines a Family of Putative Intramembrane Serine Proteases
The polytopic membrane protein Rhomboid-1 promotes the cleavage of the membrane-anchored TGFalpha-like growth factor Spitz… Expand
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Highly Cited
1999
Highly Cited
1999
Epidermal growth factor system regulates mucin production in airways.
Goblet-cell hyperplasia is a critical pathological feature in hypersecretory diseases of airways. However, the underlying… Expand
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Highly Cited
1999
Highly Cited
1999
Radiation-induced release of transforming growth factor alpha activates the epidermal growth factor receptor and mitogen-activated protein kinase pathway in carcinoma cells, leading to increased…
Exposure of A431 squamous and MDA-MB-231 mammary carcinoma cells to ionizing radiation has been associated with short transient… Expand
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Highly Cited
1999
Highly Cited
1999
Targeted inactivation of the EGF and amphiregulin genes reveals distinct roles for EGF receptor ligands in mouse mammary gland development.
Targeted mice lacking functional EGF or amphiregulin (AR) were derived and bred to the TGFalpha-knockout to generate mice lacking… Expand
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Highly Cited
1998
Highly Cited
1998
An essential role for ectodomain shedding in mammalian development.
The ectodomains of numerous proteins are released from cells by proteolysis to yield soluble intercellular regulators. The… Expand
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Highly Cited
1998
Highly Cited
1998
Expression of growth factors, growth-inhibiting factors, and their receptors in invasive breast cancer. II: Correlations with proliferation and angiogenesis.
Growth factors may play an important role in tumour growth and angiogenesis by their influence on tumour cell proliferation or… Expand
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Highly Cited
1997
Highly Cited
1997
Transforming Growth Factor-α Null and Senescent Mice Show Decreased Neural Progenitor Cell Proliferation in the Forebrain Subependyma
The adult mammalian forebrain subependyma contains neural stem cells and their progeny, the constitutively proliferating… Expand
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Highly Cited
1993
Highly Cited
1993
Elevated levels of transforming growth factor alpha and epidermal growth factor receptor messenger RNA are early markers of carcinogenesis in head and neck cancer.
The squamous mucosa of patients who develop head and neck cancer is "condemned" or predisposed to disregulated growth as… Expand
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Highly Cited
1989
Highly Cited
1989
Transforming growth factor alpha may be a physiological regulator of liver regeneration by means of an autocrine mechanism.
We investigated whether transforming growth factor alpha (TGF-alpha) is involved in hepatocyte growth responses both in vivo and… Expand
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