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- Publications
- Influence
Evolution, weighting, and phylogenetic utility of mitochondrial gene sequences and a compilation of conserved polymerase chain reaction primers
DNA-sequence data from the mitochondrial genome are being used with increasing frequency to estimate phylogenetic relationships among animal taxa. The advantage to using DNA-sequence data is that… Expand
SphK1 and SphK2, Sphingosine Kinase Isoenzymes with Opposing Functions in Sphingolipid Metabolism*
- M. Maceyka, H. Sankala, +9 authors S. Spiegel
- Medicine, Biology
- Journal of Biological Chemistry
- 4 November 2005
The potent sphingolipid metabolite sphingosine 1-phosphate is produced by phosphorylation of sphingosine catalyzed by sphingosine kinase (SphK) types 1 and 2. In contrast to pro-survival SphK1, the… Expand
Sphingosine Kinase Type 2 Is a Putative BH3-only Protein That Induces Apoptosis*
- Hong Liu, R. Toman, +9 authors S. Spiegel
- Biology, Medicine
- Journal of Biological Chemistry
- 10 October 2003
There are two isoforms of sphingosine kinase (SphK) that catalyze the formation of sphingosine 1-phosphate, a potent sphingolipid mediator. Whereas SphK1 stimulates growth and survival, here we show… Expand
Hypoxia Adaptations in the Grey Wolf (Canis lupus chanco) from Qinghai-Tibet Plateau
The Tibetan grey wolf (Canis lupus chanco) occupies habitats on the Qinghai-Tibet Plateau, a high altitude (>3000 m) environment where low oxygen tension exerts unique selection pressure on… Expand
A novel class of antagonists for the FFAs receptor GPR40.
- H. Hu, L. He, +7 authors H. Y. Wang
- Biology, Medicine
- Biochemical and biophysical research…
- 18 December 2009
The free fatty acid receptor, GPR40, is implicated in the pathophysiology of type 2 diabetes, and is a new potential drug target for the treatment of type 2 diabetes. Its antagonist is thought to be… Expand
An α-1,3-Mannosyltransferase of Cryptococcus neoformans*
- U. Sommer, Hong Liu, T. Doering
- Biology
- Journal of Biological Chemistry
- 28 November 2003
Cryptococcus neoformans is a pathogenic fungus, distinguished by an elaborate polysaccharide capsule that is essential for its virulence. As part of an effort to understand the biosynthesis of this… Expand
Ranolazine Improves Cardiac Diastolic Dysfunction Through Modulation of Myofilament Calcium Sensitivity
- Joshua D. Lovelock, Michelle M Monasky, +12 authors S. Dudley
- Medicine, Chemistry
- Circulation research
- 23 November 2010
Rationale: Previously, we demonstrated that a deoxycorticosterone acetate (DOCA)-salt hypertensive mouse model produces cardiac oxidative stress and diastolic dysfunction with preserved systolic… Expand
Sphingosine-1-phosphate and lipid phosphohydrolases.
- H. Le Stunff, Courtney Peterson, Hong Liu, S. Milstien, S. Spiegel
- Biology, Medicine
- Biochimica et biophysica acta
- 23 May 2002
Sphingosine-1-phosphate (S1P) is a bioactive sphingolipid that acts as both an extracellular ligand for the endothelial differentiation gene-1 (EDG-1) G-protein coupled receptor (GPCR) family and as… Expand
Overlapping and Distinct Roles of Aspergillus fumigatus UDP-glucose 4-Epimerases in Galactose Metabolism and the Synthesis of Galactose-containing Cell Wall Polysaccharides*
- M. Lee, Fabrice N Gravelat, +12 authors D. Sheppard
- Biology, Medicine
- The Journal of Biological Chemistry
- 20 November 2013
Background: Aspergillus fumigatus produces two galactose-containing exopolysaccharides, galactomannan and galactosaminogalactan. Results: Galactosaminogalactan synthesis requires the UDP-glucose… Expand
Molecular cloning and characterization of PtrLAR3, a gene encoding leucoanthocyanidin reductase from Populus trichocarpa, and its constitutive expression enhances fungal resistance in transgenic…
The flavonoid-derived proanthocyanidins (PAs) are one class of the major defence phenolics in poplar leaves. Transcriptional activation of PA biosynthetic genes, resulting in PA accumulation in… Expand