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Molecular pathogenesis of human hepatocellular carcinoma
Hepatocarcinogenesis is a slow process during which genomic changes progressively alter the hepatocellular phenotype to produce cellular intermediates that evolve into hepatocellular carcinoma.Expand
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A diploid epithelial cell line from normal adult rat liver with phenotypic properties of 'oval' cells.
A diploid epithelial cell line (termed WB-F344) was isolated from the liver of an adult male Fischer-344 rat and the phenotypic characteristics of the cells were studied. These cells measureExpand
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A morphologic study of deoxyribonucleic acid synthesis and cell proliferation in regenerating rat liver; autoradiography with thymidine-H3.
  • J. Grisham
  • Biology, Medicine
  • Cancer research
  • 1 August 1962
Summary A morphologic study of DNA synthesis and cellular proliferation in regenerating rat liver has been made by means of incorporation of thymidine-H3 and autoradiography. Appreciable numbers ofExpand
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NFkappaB prevents apoptosis and liver dysfunction during liver regeneration.
Although NFkappaB binding activity is induced during liver regeneration after partial hepatectomy, the physiological consequence of this induction is unknown. We have assessed the role of NFkappaBExpand
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Temporal analysis of hepatocyte differentiation by small hepatocyte-like progenitor cells during liver regeneration in retrorsine-exposed rats.
Liver regeneration after two-thirds surgical partial hepatectomy (PH) in rats treated with the pyrrolizidine alkaloid retrorsine is accomplished through the activation, expansion, and differentiationExpand
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Liver regeneration in rats with retrorsine-induced hepatocellular injury proceeds through a novel cellular response.
The adult rodent liver contains at least two recognized populations of cells with stem-like properties that contribute to liver repair/regeneration under different pathophysiological circumstances:Expand
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Interspecies comparison of liver carcinogenesis: implications for cancer risk assessment.
The morphology of hepatocellular carcinoma is similar among mice, rats and humans, and the cellular pathogenesis shows features that are both similar and divergent among these species. However, majorExpand
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  • J. Grisham
  • Biology, Medicine
  • Annals of the New York Academy of Sciences
  • 1 September 1980
Under the conditions of this experiment, propagable hepatic epithelial cells in long‐term culture were derived from a small, nonparenchymal precursor cell present in the liver in vivo. Progeny of theExpand
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Comparative functional genomics for identifying models of human cancer.
Genetically modified mice with overexpressed and/or deleted genes have been used extensively to model human cancer. However, it is uncertain as to what extent the mouse models reproduce theExpand
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