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Transforming Growth Factor beta

Known as: TGFbeta, Milk Growth Factor, Transforming growth factors-beta 
A factor synthesized in a wide variety of tissues. It acts synergistically with TGF-alpha in inducing phenotypic transformation and can also act as a… 
National Institutes of Health

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31 relations
Cell Differentiation processCell Proliferation Regulatory ProcessExtracellular SpaceGDNF protein, human
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Vg1 protein, XenopusbetaIG-H3 proteindvr1 protein, zebrafishfugacin
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Papers overview

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Highly Cited
2007
Highly Cited
2007
Interleukins 1beta and 6 but not transforming growth factor-beta are essential for the differentiation of interleukin 17-producing human T helper cells.
Interleukin 17 (IL-17)-producing CD4(+) helper T cells (T(H)-17 cells) have been linked to host defense and autoimmune diseases… 
Highly Cited
1996
Highly Cited
1996
A critical role for transforming growth factor-beta but not interleukin 4 in the suppression of T helper type 1-mediated colitis by CD45RB(low) CD4+ T cells
A T helper type 1 (Th1)-mediated colitis with similarities to inflammatory bowel disease in humans developed in severe combined… 
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Highly Cited
1994
Highly Cited
1994
Angiotensin II stimulates extracellular matrix protein synthesis through induction of transforming growth factor-beta expression in rat glomerular mesangial cells.
Angiotensin II (Ang II) has been implicated in the development of progressive glomerulosclerosis, but the precise mechanism of… 
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Highly Cited
1992
Highly Cited
1992
Endoglin is a component of the transforming growth factor-beta receptor system in human endothelial cells.
Endoglin, a dimeric membrane glycoprotein expressed at high levels on human vascular endothelial cells, shares regions of… 
Review
1990
Review
1990
The transforming growth factor-beta family.
  • J. Massagué
  • Annual review of cell biology
  • 1990
  • Corpus ID: 35109826
Highly Cited
1988
Highly Cited
1988
Proteolytic activation of latent transforming growth factor-beta from fibroblast-conditioned medium
Transforming growth factor-beta (TGF beta) is produced by most cultured cells in an inactive form. Potential activation… 
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Highly Cited
1987
Highly Cited
1987
Accelerated healing of incisional wounds in rats induced by transforming growth factor-beta.
The role of polypeptide growth factors in the processes of inflammation and repair was investigated by analyzing the influence of… 
Highly Cited
1986
Highly Cited
1986
Transforming growth factor type beta: rapid induction of fibrosis and angiogenesis in vivo and stimulation of collagen formation in vitro.
Transforming growth factor type beta (TGF-beta), when injected subcutaneously in newborn mice, causes formation of granulation… 
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Highly Cited
1986
Highly Cited
1986
Transforming growth factor-beta stimulates the expression of fibronectin and collagen and their incorporation into the extracellular matrix.
We have examined whether the extracellular matrix is a biochemical target for transforming growth factor-beta (TGFbeta). We find… 
Highly Cited
1983
Highly Cited
1983
Transforming growth factor-beta in human platelets. Identification of a major storage site, purification, and characterization.
Acidic ethanol extracts of human platelets induced non-neoplastic normal rat kidney fibroblasts to undergo anchorage-independent… 
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