Transforming Growth Factor beta

Known as: TGFbeta, Milk Growth Factor, Transforming growth factors-beta 
A factor synthesized in a wide variety of tissues. It acts synergistically with TGF-alpha in inducing phenotypic transformation and can also act as a… (More)
National Institutes of Health

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Papers overview

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Review
2016
Review
2016
Signalling by Transforming Growth Factor Beta Isoforms in Wound Healing and Tissue Regeneration
Transforming growth factor beta (TGFβ) signalling is essential for wound healing, including both non-specific scar formation and… (More)
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Highly Cited
2007
Highly Cited
2007
Interleukins 1beta and 6 but not transforming growth factor-beta are essential for the differentiation of interleukin 17-producing human T helper cells.
Interleukin 17 (IL-17)-producing CD4(+) helper T cells (T(H)-17 cells) have been linked to host defense and autoimmune diseases… (More)
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Highly Cited
2006
Highly Cited
2006
Transforming growth factor-beta controls development, homeostasis, and tolerance of T cells by regulatory T cell-dependent and -independent mechanisms.
The role of transforming growth factor-beta (TGF-beta) in inhibiting T cell functions has been studied with dominant-negative TGF… (More)
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Highly Cited
2001
Highly Cited
2001
Smurf1 interacts with transforming growth factor-beta type I receptor through Smad7 and induces receptor degradation.
Smad7 is an inhibitory Smad that acts as a negative regulator of signaling by the transforming growth factor-beta (TGF-beta… (More)
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Highly Cited
2001
Highly Cited
2001
Induction and mechanism of action of transforming growth factor-beta-secreting Th3 regulatory cells.
Th3 CD4+ regulatory cells were identified during the course of investigating mechanisms associated with oral tolerance. Different… (More)
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Highly Cited
1994
Highly Cited
1994
Angiotensin II stimulates extracellular matrix protein synthesis through induction of transforming growth factor-beta expression in rat glomerular mesangial cells.
Angiotensin II (Ang II) has been implicated in the development of progressive glomerulosclerosis, but the precise mechanism of… (More)
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Highly Cited
1992
Highly Cited
1992
Endoglin is a component of the transforming growth factor-beta receptor system in human endothelial cells.
Endoglin, a dimeric membrane glycoprotein expressed at high levels on human vascular endothelial cells, shares regions of… (More)
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Highly Cited
1986
Highly Cited
1986
Transforming growth factor-beta stimulates the expression of fibronectin and collagen and their incorporation into the extracellular matrix.
We have examined whether the extracellular matrix is a biochemical target for transforming growth factor-beta (TGFbeta). We find… (More)
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Highly Cited
1986
Highly Cited
1986
Transforming growth factor type beta: rapid induction of fibrosis and angiogenesis in vivo and stimulation of collagen formation in vitro.
Transforming growth factor type beta (TGF-beta), when injected subcutaneously in newborn mice, causes formation of granulation… (More)
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Highly Cited
1983
Highly Cited
1983
Transforming growth factor-beta in human platelets. Identification of a major storage site, purification, and characterization.
Acidic ethanol extracts of human platelets induced non-neoplastic normal rat kidney fibroblasts to undergo anchorage-independent… (More)
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