Interleukin-12 and the regulation of innate resistance and adaptive immunity
- G. Trinchieri
- BiologyNature reviews. Immunology
- 1 February 2003
The understanding of the relative roles of IL-12 and other factors in TH1-type maturation of both CD4+ and CD8+ T cells is discussed here, including the participation in this process ofIL-23 and IL-27, two recently discovered members of the new family of heterodimeric cytokines.
Plasmacytoid dendritic cells in immunity
Recent progress on the characterization of plasmacytoid dendritic cell origin, development, migration and function in immunity and tolerance, as well as their effect on human diseases are reviewed.
Interleukin-12: a proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity.
- G. Trinchieri
- BiologyAnnual Review of Immunology
IL-12 represents a functional bridge between the early nonspecific innate resistance and the subsequent antigen-specific adaptive immunity in the innate resistance/adaptive immune response to infection.
Biology of Natural Killer Cells
- G. Trinchieri
- Biology, MedicineAdvances in Immunology
- 31 December 1989
Cooperation of Toll-like receptor signals in innate immune defence
This Review highlights recent advances in the newly emerging field of TLR cooperation and discusses their implications for the development of adjuvants and immunotherapies.
Commensal Bacteria Control Cancer Response to Therapy by Modulating the Tumor Microenvironment
Optimal responses to cancer therapy require an intact commensal microbiota that mediates its effects by modulating myeloid-derived cell functions in the tumor microenvironment, and disruption of the microbiota impairs the response of subcutaneous tumors to CpG-oligonucleotide immunotherapy and platinum chemotherapy.
Mouse type I IFN-producing cells are immature APCs with plasmacytoid morphology
It is shown that mouse interferon-α–producing cells (mIPCs) are a unique subset of immature antigen-presenting cells (APCs) that secrete IFN-α upon stimulation with viruses and interleukin 12 (IL-12) in response to viruses and CpG oligodeoxynucleotides, but not bacterial products.
A type I interferon autocrine–paracrine loop is involved in Toll-like receptor-induced interleukin-12p70 secretion by dendritic cells
Analysis of interferon regulatory factors (IRF) regulation in moDC suggests a role for IRF7/8 in mediating IRF3-independent type I IFN and possibly IL-12p35 synthesis in response to TLR7/9 and R-848/Resiquimod synergized with poly(I:C) (TLR3 ligand) or lipopolysaccharide (LPS; TLR4 ligand).
Interleukin 10 (IL-10) inhibits human lymphocyte interferon gamma- production by suppressing natural killer cell stimulatory factor/IL-12 synthesis in accessory cells
- A. D’Andrea, M. Aste‐Amezaga, N. Valiante, X. Ma, M. Kubin, G. Trinchieri
- Biology, MedicineJournal of Experimental Medicine
- 1 September 1993
It is shown that IL-10 is a potent inhibitor of NKSF/IL-12 production from human peripheral blood mononuclear cells activated with Staphylococcus aureus or lipopolysaccharide (LPS), and that antibodies against NKSF-12, TNF-alpha, or IL-1 beta can significantly inhibit IFN-gamma production in response to various stimuli.
Identification and purification of natural killer cell stimulatory factor (NKSF), a cytokine with multiple biologic effects on human lymphocytes
Data strongly suggest that the same molecule mediates these three activities, although the presence of traces of contaminant peptides even in the most purified NKSF preparations does not allow us to exclude the possibility that distinct biologically active molecules have been co-purified.