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Essential Role for TrkB Receptors in Hippocampus-Mediated Learning
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Targeted disruption of the glucocorticoid receptor gene blocks adrenergic chromaffin cell development and severely retards lung maturation.
TLDR
The results suggest that the adrenal medulla may be formed from two different cell populations: adrenergic-specific cells that require glucocorticoids for proliferation and/or survival, and a smaller noradrenergic population that differentiates normally in the absence of glucOCorticoid signaling.
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Kinase-Independent Requirement of EphB2 Receptors in Hippocampal Synaptic Plasticity
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Distinct sites of intracellular production for Alzheimer's disease Aβ40/42 amyloid peptides
TLDR
The specific production of the critical Aβ isoform in the ER of neurons links this compartment with the generation of Aβ and explains why primarily ER localized (mutant) proteins such as the presenilins3 could induce AD.
View on Nature
TGF‐beta superfamily members promote survival of midbrain dopaminergic neurons and protect them against MPP+ toxicity.
TLDR
It is concluded that TGF‐beta s 1‐3, activin A and GDNF share a neurotrophic capacity for developing dopaminergic neurons, which is not mediated by astroglial cells and not accompanied by an increase in cell proliferation.
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Glial Cell Line-Derived Neurotrophic Factor Requires Transforming Growth Factor-β for Exerting Its Full Neurotrophic Potential on Peripheral and CNS Neurons
TLDR
It is shown on a variety of cultured neurons including peripheral autonomic, sensory, and CNS dopaminergic neurons that GDNF is not trophically active unless supplemented with TGF-β, and the definition of a neurotrophic factor is broadened by incorporating the possibility that two factors that lack an neurotrophic activity when acting separately become neurotrophic when acting in concert.
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The transforming growth factor-betas: structure, signaling, and roles in nervous system development and functions.
TLDR
The current state of knowledge concerning the roles of TGF-betas in controlling neuronal performances, including the regulation of proliferation of neuronal precursors, survival/death decisions, and neuronal differentiation is reviewed.
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Bone Morphogenetic Proteins: Neurotrophic Roles for Midbrain Dopaminergic Neurons and Implications of Astroglial Cells
TLDR
It is shown that BMP 2 and BMP 6 are expressed in the developing midbrain floor of the rat and share a neurotrophic capacity for dopaminergic midbrain neurons with other members of the TGF‐β superfamily, but act indirectly, possibly through glial cells.
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TrkB regulates neocortex formation through the Shc/PLCγ‐mediated control of neuronal migration
TLDR
Genetic evidence is provided that TrkB regulates important functions throughout the formation of the cerebral cortex via recruitment of the Shc/FRS2 adaptors and PLCγ.
View on Wiley
Transforming growth factor beta isoforms in the adult rat central and peripheral nervous system
View on Elsevier
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