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TOR complex 2

Known as: mTOR Complex 2, Target of Rapamycin Complex 2, TORC2 
A protein complex that is involved in both serine/threonine phosphorylation and cytoskeleton remodeling in response to cellular stress.
National Institutes of Health

Related topics

Related topics

7 relations
DEP Domain-Containing mTOR-Interacting ProteinFRAP1 protein, humanMTOR geneSerine/Threonine Phosphorylation

Broader (2)

FKBP12-rapamycin associated proteinMultiprotein Complexes

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
The Kinase Complex mTOR Complex 2 Promotes the Follicular Migration and Functional Maturation of Differentiated Follicular Helper CD4+ T Cells During Viral Infection
Follicular helper CD4+ T (TFH) cells are critical for optimal B-cell-mediated humoral immunity by initiating, fueling, and… 
2018
2018
Rab5 GTPases are required for optimal TORC2 function
Target of rapamycin complex-2 (TORC2), a conserved protein kinase complex, is an indispensable regulator of plasma membrane… 
Review
2014
Review
2014
Insight into Tor2, a budding yeast microdomain protein.
2013
2013
Target of rapamycin (TOR) kinase in Trypanosoma brucei: an extended family.
The complex life cycle of Trypanosoma brucei provides an excellent model system to understand signalling pathways that regulate… 
2013
2013
A dual mTORC1 and mTORC2 inhibitor shows antitumor activity in esophageal squamous cell carcinoma cells and sensitizes them to cisplatin
The mammalian target of rapamycin (mTOR) signaling pathway is critical for the growth and proliferation of various malignant… 
2011
2011
Constitutive activation with overexpression of the mTORC2-phospholipase D1 pathway in uterine leiomyosarcoma and STUMP: morphoproteomic analysis with therapeutic implications.
The mammalian target of rapamycin (mTOR) is centrally involved in growth, survival and metabolism. In cancer, mTOR is frequently… 
Highly Cited
2010
Highly Cited
2010
A phase I dose-escalation study of the safety, pharmacokinetics (PK), and pharmacodynamics of XL765 (SAR245409), a PI3K/TORC1/TORC2 inhibitor administered orally to patients (pts) with advanced…
3030 Background: XL765 is a potent and selective inhibitor of class I PI3K isoforms, TORC1, and TORC2. XL765 has shown dose… 
2010
2010
Glycogen Synthase Kinase-3 Is Required for Efficient Dictyostelium Chemotaxis
We present a new role for glycogen synthase kinase (GSK) in the regulation of aggregation and chemotaxis in Dictyostelium. GSK… 
Review
2010
Review
2010
Protein kinase C - a family of protein kinases, allosteric effectors or both?
2008
2008
MHC class I and integrin ligation induce ERK activation via an mTORC2-dependent pathway.
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