TOR complex 2

Known as: mTOR Complex 2, Target of Rapamycin Complex 2, TORC2 
A protein complex that is involved in both serine/threonine phosphorylation and cytoskeleton remodeling in response to cellular stress.

Topic mentions per year

Topic mentions per year

2005-2017
051020052017

Papers overview

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2015
2015
The Target Of Rapamycin (TOR) is an evolutionarily conserved protein kinase that forms 2 distinct protein complexes referred to… (More)
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2013
2013
PURPOSE The multikinase inhibitor sorafenib displays antitumor activity in preclinical models of osteosarcoma. However, in… (More)
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2012
2012
The yeast AGC kinase orthologs Ypk1 and Ypk2 control several important cellular processes, including actin polarization… (More)
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2010
2010
BACKGROUND From yeast to human, TOR (target of rapamycin) kinase plays pivotal roles in coupling extracellular stimuli to cell… (More)
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2009
2009
The Target Of Rapamycin (TOR) kinase belongs to the highly conserved eukaryotic family of phosphatidylinositol-3-kinase-related… (More)
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Highly Cited
2009
Highly Cited
2009
The conserved target of rapamycin (TOR) kinases regulate many aspects of cellular physiology. They exist in two distinct… (More)
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Highly Cited
2008
Highly Cited
2008
SGK1 (serum- and glucocorticoid-induced protein kinase 1) is a member of the AGC (protein kinase A/protein kinase G/protein… (More)
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Highly Cited
2008
Highly Cited
2008
The mammalian target of rapamycin (mTOR) is a protein kinase that forms two functionally distinct complexes important for… (More)
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Highly Cited
2007
Highly Cited
2007
The mTOR complex 2 (mTORC2) containing mTOR and rictor is thought to be rapamycin insensitive and was recently shown to regulate… (More)
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Highly Cited
2005
Highly Cited
2005
Deregulation of Akt/protein kinase B (PKB) is implicated in the pathogenesis of cancer and diabetes. Akt/PKB activation requires… (More)
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