Constitutive activation with overexpression of the mTORC2-phospholipase D1 pathway in uterine leiomyosarcoma and STUMP: morphoproteomic analysis with therapeutic implications.

@article{Dhingra2010ConstitutiveAW,
  title={Constitutive activation with overexpression of the mTORC2-phospholipase D1 pathway in uterine leiomyosarcoma and STUMP: morphoproteomic analysis with therapeutic implications.},
  author={Sadhna Dhingra and M Encarnacion Rodriguez and Qi Zhang Shen and Xuizhen Duan and Melissa L. Stanton and Lei Chen and Rongzhen Zhang and Robert E. Brown},
  journal={International journal of clinical and experimental pathology},
  year={2010},
  volume={4 2},
  pages={
          134-46
        }
}
The mammalian target of rapamycin (mTOR) is centrally involved in growth, survival and metabolism. In cancer, mTOR is frequently hyperactivated and is a clinically validated target for therapy and drug development. Biologically, mTOR acts as the catalytic subunit of two functionally distinct complexes, called mTOR complex 1 (mTORC1) which is predominantly cytoplasmic in subcellular localization and mTOR complex 2 (mTORC2) which is both cytoplasmic and nuclear. mTORC1 is sensitive to the… CONTINUE READING

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