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Autophagy is a process by which components of the cell are degraded to maintain essential activity and viability in response to… Expand Antidepressant Action of Ketamine In contrast to the weeks or months of treatment required for standard antidepressant medication… Expand The mammalian target of rapamycin (mTOR) has emerged as a critical effector in cell-signaling pathways commonly deregulated in… Expand Stimulation of the insulin and insulin-like growth factor I (IGF-I) receptor activates the phosphoinositide-3-kinase/Akt/mTOR… Expand Deregulation of Akt/protein kinase B (PKB) is implicated in the pathogenesis of cancer and diabetes. Akt/PKB activation requires… Expand The mammalian TOR (mTOR) pathway integrates nutrient- and growth factor-derived signals to regulate growth, the process whereby… Expand Huntington disease is one of nine inherited neurodegenerative disorders caused by a polyglutamine tract expansion. Expanded… Expand Tuberous sclerosis (TSC) is an autosomal dominant disorder characterized by the formation of hamartomas in a wide range of human… Expand mTOR/RAFT1/FRAP is the target of the immunosuppressive drug rapamycin and the central component of a nutrient- and hormone… Expand Skeletal muscles adapt to changes in their workload by regulating fibre size by unknown mechanisms. The roles of two signalling… Expand