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FRAP1 protein, human

Known as: RAFT1 protein, human, FKBP12-Rapamycin Complex-Associated Protein, FKBP-Rapamycin Associated Protein 
A protein that helps control several cell functions, including cell division and survival, and binds to rapamycin and other drugs. Mammalian target… Expand
National Institutes of Health

Papers overview

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Highly Cited
2011
Highly Cited
2011
Autophagy is a process by which components of the cell are degraded to maintain essential activity and viability in response to… Expand
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Highly Cited
2010
Highly Cited
2010
Antidepressant Action of Ketamine In contrast to the weeks or months of treatment required for standard antidepressant medication… Expand
Review
2007
Review
2007
The mammalian target of rapamycin (mTOR) has emerged as a critical effector in cell-signaling pathways commonly deregulated in… Expand
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Highly Cited
2006
Highly Cited
2006
Stimulation of the insulin and insulin-like growth factor I (IGF-I) receptor activates the phosphoinositide-3-kinase/Akt/mTOR… Expand
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Highly Cited
2005
Highly Cited
2005
Deregulation of Akt/protein kinase B (PKB) is implicated in the pathogenesis of cancer and diabetes. Akt/PKB activation requires… Expand
Highly Cited
2004
Highly Cited
2004
The mammalian TOR (mTOR) pathway integrates nutrient- and growth factor-derived signals to regulate growth, the process whereby… Expand
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Highly Cited
2004
Highly Cited
2004
Huntington disease is one of nine inherited neurodegenerative disorders caused by a polyglutamine tract expansion. Expanded… Expand
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Highly Cited
2002
Highly Cited
2002
Tuberous sclerosis (TSC) is an autosomal dominant disorder characterized by the formation of hamartomas in a wide range of human… Expand
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Highly Cited
2002
Highly Cited
2002
mTOR/RAFT1/FRAP is the target of the immunosuppressive drug rapamycin and the central component of a nutrient- and hormone… Expand
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Highly Cited
2001
Highly Cited
2001
Skeletal muscles adapt to changes in their workload by regulating fibre size by unknown mechanisms. The roles of two signalling… Expand
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