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FRAP1 protein, human

Known as: RAFT1 protein, human, FKBP12-Rapamycin Complex-Associated Protein, FKBP-Rapamycin Associated Protein 
A protein that helps control several cell functions, including cell division and survival, and binds to rapamycin and other drugs. Mammalian target… 
National Institutes of Health

Related topics

Related topics

27 relations
Adipocytokine Signaling PathwayCTCF PathwayCell Proliferation Regulatory ProcessEF-1 Peptide

Broader (2)

FKBP12-rapamycin associated proteinProtein-Serine-Threonine Kinases

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2017
Highly Cited
2017
Vertical inhibition of the PI3K/Akt/mTOR pathway is synergistic in breast cancer
Deregulation and activation of the phosphoinositide 3-kinase (PI3K)/Akt/mammalian (or mechanistic) target of rapamycin (mTOR… 
Highly Cited
2014
Highly Cited
2014
Melatonin Inhibits mTOR-Dependent Autophagy during Liver Ischemia/Reperfusion
Background: Autophagy is a self-digestion system responsible for maintaining cellular homeostasis and interacts with reactive… 
Highly Cited
2010
Highly Cited
2010
Ischemic post-conditioning reduces infarct size of the in vivo rat heart: role of PI3-K, mTOR, GSK-3β, and apoptosis
Post-conditioning by repetitive cycles of reperfusion/ischemia after prolonged ischemia protects the heart from infarction. The… 
Review
2009
Review
2009
Enhancing mTOR-targeted cancer therapy
Background: The mammalian target of rapamycin (mTOR) has emerged as an attractive cancer therapeutic target. Accordingly, several… 
2009
2009
Developing Antiepileptogenic Drugs for Acquired Epilepsy: Targeting the Mammalian Target of Rapamycin (mTOR) Pathway.
While current medications for epilepsy are primarily symptomatic treatments that suppress seizures, one of the main goals of… 
Highly Cited
2008
Highly Cited
2008
Photic regulation of the mTOR signaling pathway in the suprachiasmatic circadian clock
Highly Cited
2006
Highly Cited
2006
New polyphenol derivative in Ipomoea batatas tubers and its antioxidant activity.
Four different polyphenolic compounds were isolated by chromatographic methods from methanolic and hydromethanolic extracts of… 
Highly Cited
2005
Highly Cited
2005
Disruption of parallel and converging signaling pathways contributes to the synergistic antitumor effects of simultaneous mTOR and EGFR inhibition in GBM cells.
Elevated epidermal growth factor receptor (EGFR) and mammalian target of rapamycin (mTOR) signaling are known to contribute to… 
Highly Cited
2000
Highly Cited
2000
Carboxyl‐terminal region conserved among phosphoinositide‐kinase‐related kinases is indispensable for mTOR function in vivo and in vitro
The mammalian target of rapamycin (mTOR) belongs to the family of phosphoinositide (PI)‐kinase‐related kinases that includes the… 
Highly Cited
1995
Highly Cited
1995
The Rapamycin and FKBP12 Target (RAFT) Displays Phosphatidylinositol 4-Kinase Activity (*)
The immunosuppressant rapamycin prevents cell cycle progression in several mammalian cell lines and the yeast Saccharomyces… 
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