FKBP12-rapamycin associated protein

Known as: mTOR Serine Threonine Kinases, Associated Protein, FKBP12-Rapamycin, Protein, mTOR 
A serine threonine kinase that controls a wide range of growth-related cellular processes. The protein is referred to as the target of RAPAMYCIN due… (More)
National Institutes of Health

Related topics

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14 relations

Narrower (3)

FRAP1 protein, humanTOR complex 2mechanistic target of rapamycin complex 1
In BloodMTOR geneProcess of secretionRNA, Messenger
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Broader (1)

Protein Kinases

Papers overview

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Highly Cited
2012
Highly Cited
2012
Mixed Lineage Kinase Domain-like Protein Mediates Necrosis Signaling Downstream of RIP3 Kinase
The receptor-interacting serine-threonine kinase 3 (RIP3) is a key signaling molecule in the programmed necrosis (necroptosis… (More)
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Review
2009
Review
2009
From promiscuity to precision: protein phosphatases get a makeover.
The control of biological events requires strict regulation using complex protein phosphorylation and dephosphorylation… (More)
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Highly Cited
2006
Highly Cited
2006
SIN1/MIP1 Maintains rictor-mTOR Complex Integrity and Regulates Akt Phosphorylation and Substrate Specificity
Mammalian target of rapamycin (mTOR) controls cell growth and proliferation via the raptor-mTOR (TORC1) and rictor-mTOR (TORC2… (More)
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Highly Cited
2005
Highly Cited
2005
Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex.
Deregulation of Akt/protein kinase B (PKB) is implicated in the pathogenesis of cancer and diabetes. Akt/PKB activation requires… (More)
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Highly Cited
2004
Highly Cited
2004
Rictor, a Novel Binding Partner of mTOR, Defines a Rapamycin-Insensitive and Raptor-Independent Pathway that Regulates the Cytoskeleton
The mammalian TOR (mTOR) pathway integrates nutrient- and growth factor-derived signals to regulate growth, the process whereby… (More)
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Highly Cited
2004
Highly Cited
2004
Determinants of rapamycin sensitivity in breast cancer cells.
PURPOSE Rapamycin inhibits the serine-threonine kinase mammalian target of rapamycin (mTOR), blocking phosphorylation of p70 S6… (More)
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Highly Cited
2002
Highly Cited
2002
Phenotypic spectrum caused by transgenic overexpression of activated Akt in the heart.
The serine-threonine kinase, Akt, inhibits cardiomyocyte apoptosis acutely both in vitro and in vivo. However, the effects of… (More)
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Highly Cited
2000
Highly Cited
2000
Modulation of Akt kinase activity by binding to Hsp90.
Serine/threonine kinase Akt/PKB is a downstream effector molecule of phosphoinositide 3-kinase and is thought to mediate many… (More)
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Highly Cited
2000
Highly Cited
2000
Angiopoietin-1 regulates endothelial cell survival through the phosphatidylinositol 3'-Kinase/Akt signal transduction pathway.
Angiopoietin-1 (Ang1) is a strong apoptosis survival factor for endothelial cells. In this study, the receptor/second messenger… (More)
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Highly Cited
1998
Highly Cited
1998
Vascular endothelial growth factor regulates endothelial cell survival through the phosphatidylinositol 3'-kinase/Akt signal transduction pathway. Requirement for Flk-1/KDR activation.
Vascular endothelial growth factor (VEGF) has been found to have various functions on endothelial cells, the most prominent of… (More)
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