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FKBP12-rapamycin associated protein

Known as: mTOR Serine Threonine Kinases, Associated Protein, FKBP12-Rapamycin, Protein, mTOR 
A serine threonine kinase that controls a wide range of growth-related cellular processes. The protein is referred to as the target of RAPAMYCIN due… 
National Institutes of Health

Related topics

Related topics

14 relations

Narrower (3)

FRAP1 protein, humanTOR complex 2mechanistic target of rapamycin complex 1
In BloodMTOR geneProcess of secretionRNA, Messenger

Broader (1)

Protein Kinases

Papers overview

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Highly Cited
2007
Highly Cited
2007
Probing the membrane environment of the TOR kinases reveals functional interactions between TORC1, actin, and membrane trafficking in Saccharomyces cerevisiae.
The TOR kinases are regulators of growth in eukaryotic cells that assemble into two distinct protein complexes, TORC1 and TORC2… 
Highly Cited
2007
Highly Cited
2007
Discovery of lactoquinomycin and related pyranonaphthoquinones as potent and allosteric inhibitors of AKT/PKB: mechanistic involvement of AKT catalytic activation loop cysteines
The serine/threonine kinase AKT/PKB plays a critical role in cancer and represents a rational target for therapy. Although… 
2007
2007
Distant N- and C-terminal Domains Are Required for Intrinsic Kinase Activity of SMG-1, a Critical Component of Nonsense-mediated mRNA Decay*
Phosphatidylinositol 3-kinase-related kinases (PIKKs) consisting of SMG-1, ATM, ATR, DNA-PKcs, and mTOR are a family of proteins… 
Highly Cited
2002
Highly Cited
2002
The Flavoprotein MrsD Catalyzes the Oxidative Decarboxylation Reaction Involved in Formation of the Peptidoglycan Biosynthesis Inhibitor Mersacidin
ABSTRACT The lantibiotic mersacidin inhibits peptidoglycan biosynthesis by binding to the peptidoglycan precursor lipid II… 
Highly Cited
1998
Highly Cited
1998
Occurrence of an Unusual Phospholipid, Phosphatidyl-l-threonine, in Cultured Hippocampal Neurons
We have recently reported thatl-serine released from astroglial cells supports the survival and neuritogenesis of hippocampal… 
Highly Cited
1990
Highly Cited
1990
Multisite phosphorylation of the epidermal growth factor receptor. Use of site-directed mutagenesis to examine the role of serine/threonine phosphorylation.
Highly Cited
1990
Highly Cited
1990
One amino acid change produces a high affinity cGMP-binding site in cAMP-dependent protein kinase.
Highly Cited
1978
Highly Cited
1978
Baclofen: effects on amino acid release.
This study investigated the effects of the antispastic drug β-(p-chlorophenyl)-γ-amino-butyric acid (Baclofen) on the release of… 
1977
1977
Hydrolytic action of aminoacyl-tRNA synthetases from baker's yeast. "Chemical proofreading" of Thr-tRNA Val by valyl-tRNA synthetase studied with modified tRNA Val and amino acid analogues.
The properties of native and of two modified tRNA Val species in the correction of misactivated threonine by valyl-tRNA… 
1954
1954
C-Terminal groups in myosin, tropomyosin and actin.
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