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Structure and physiological function of calpains.
TLDR
Findings indicate various important functional roles for intracellular proteases belonging to the calpain superfamily. Expand
Tissue-specific expression and alpha-actinin binding properties of the Z-disc titin: implications for the nature of vertebrate Z-discs.
TLDR
Alternative splicing of the Z-disc titin appears to be important for the tissue and fibre type diversity of the X-disc lattice, and may explain how alpha-actinins can cross-link antiparallel titin and thin filaments from opposing sarcomeres. Expand
The VNTR polymorphism of the human dopamine transporter (DAT1) gene affects gene expression
TLDR
Luciferase expression was significantly higher when the 3′-UTR of the DAT1 gene contained the 10-repeat allele than when it contained the 7- or 9-repeat alleles, suggesting that VNTR polymorphism affects the expression of the dopamine transporter. Expand
Membrane-anchored metalloprotease MDC9 has an alpha-secretase activity responsible for processing the amyloid precursor protein.
TLDR
It is demonstrated that MDC9 expressed in COS cells is cleaved between the prodomain and the metalloprotease domain, suggesting that M DC9 has an alpha-secretase-like activity and is activated by phorbol ester. Expand
MKBP, a Novel Member of the Small Heat Shock Protein Family, Binds and Activates the Myotonic Dystrophy Protein Kinase
TLDR
The results suggest that MKBP constitutes a novel stress-responsive system independent of other known sHSPs in muscle cells and that DMPK may be involved in this system by being activated by MKBP. Expand
Muscleblind protein, MBNL1/EXP, binds specifically to CHHG repeats.
TLDR
Deletion analysis indicates a difference in RNA-binding abilities among splice variants of MBNL1, and it was found thatMBNL1 can bind to repetitive motifs in ZNF9, which contain a minimal length of CCUG repeats with non-CCUG insertions. Expand
Molecular links among the causative genes for ocular malformation: Otx2 and Sox2 coregulate Rax expression
TLDR
It is demonstrated that the direct interaction and interdependence between the Otx2 and Sox2 proteins coordinate Rax expression in eye development, providing molecular linkages among the genes responsible for ocular malformation. Expand
Muscle-specific Calpain, p94, Responsible for Limb Girdle Muscular Dystrophy Type 2A, Associates with Connectin through IS2, a p94-specific Sequence (*)
TLDR
Connectin, a gigantic filamentous protein spanning the M- to Z-lines of muscle sarcomere, was found to bind to p94 through a p94-specific region, IS2, and the connectin-insoluble fraction of washed myofibrils contained full-length intact p94, suggesting that connectin regulates p94 activity. Expand
The protease activity of a calpain-like cysteine protease in Saccharomyces cerevisiae is required for alkaline adaptation and sporulation
TLDR
Results indicate that a calpain-like cysteine protease, Cpl1p, plays an important role in alkaline adaptation and sporulation processes, via regulation of the turnover and processing of the transcription factor Rim101p. Expand
Muscle-specific calpain, p94, interacts with the extreme C-terminal region of connectin, a unique region flanked by two immunoglobulin C2 motifs.
TLDR
The results suggest that the interaction between p94 and the C-terminus of skeletal muscle-type connectin is involved in tissue-specific myofibriogenesis. Expand
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