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mechanistic target of rapamycin complex 1

Known as: TORC1, Target of Rapamycin Complex 1, mTORC1 
A protein complex that is involved in the both serine/threonine phosphorylation and the regulation of protein synthesis in response to cellular… 
National Institutes of Health

Related topics

Related topics

7 relations
DEP Domain-Containing mTOR-Interacting ProteinFRAP1 protein, humanMTOR geneSerine/Threonine Phosphorylation

Broader (2)

FKBP12-rapamycin associated proteinMultiprotein Complexes

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2014
Review
2014
Mammalian target of rapamycin signaling in cardiac physiology and disease.
The protein kinase mammalian or mechanistic target of rapamycin (mTOR) is an atypical serine/threonine kinase that exerts its… 
Review
2014
Review
2014
Growing knowledge of the mTOR signaling network.
Highly Cited
2012
Highly Cited
2012
Leucyl-tRNA synthetase controls TORC1 via the EGO complex.
Review
2012
Review
2012
Bidirectional crosstalk between endoplasmic reticulum stress and mTOR signaling.
Highly Cited
2011
Highly Cited
2011
Role of mTOR in podocyte function and diabetic nephropathy in humans and mice.
Chronic glomerular diseases, associated with renal failure and cardiovascular morbidity, represent a major health issue. However… 
Highly Cited
2011
Highly Cited
2011
mTORC1 activation in podocytes is a critical step in the development of diabetic nephropathy in mice.
Diabetic nephropathy (DN) is among the most lethal complications that occur in type 1 and type 2 diabetics. Podocyte dysfunction… 
Highly Cited
2010
Highly Cited
2010
LKB1 regulates quiescence and metabolic homeostasis of hematopoietic stem cells
The capacity to fine-tune cellular bioenergetics with the demands of stem-cell maintenance and regeneration is central to normal… 
Highly Cited
2010
Highly Cited
2010
Effective and selective targeting of leukemia cells using a TORC1/2 kinase inhibitor
Targeting the mammalian target of rapamycin (mTOR) protein is a promising strategy for cancer therapy. The mTOR kinase functions… 
Highly Cited
2010
Highly Cited
2010
Beyond rapalog therapy: preclinical pharmacology and antitumor activity of WYE-125132, an ATP-competitive and specific inhibitor of mTORC1 and mTORC2.
The mammalian target of rapamycin (mTOR) is a major component of the phosphoinositide 3-kinase (PI3K)/AKT signaling pathway that… 
Review
2009
Review
2009
mTOR Mediated Anti-Cancer Drug Discovery.
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