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mechanistic target of rapamycin complex 1

Known as: TORC1, Target of Rapamycin Complex 1, mTORC1 
A protein complex that is involved in the both serine/threonine phosphorylation and the regulation of protein synthesis in response to cellular… 
National Institutes of Health

Related topics

Related topics

7 relations
DEP Domain-Containing mTOR-Interacting ProteinFRAP1 protein, humanMTOR geneSerine/Threonine Phosphorylation

Broader (2)

FKBP12-rapamycin associated proteinMultiprotein Complexes

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2015
2015
Inhibition of mTOR by Rapamycin Results in Auditory Hair Cell Damage and Decreased Spiral Ganglion Neuron Outgrowth and Neurite Formation In Vitro
Rapamycin is an antifungal agent with immunosuppressive properties. Rapamycin inhibits the mammalian target of rapamycin (mTOR… 
2015
2015
Synergistic Effects between mTOR Complex 1/2 and Glycolysis Inhibitors in Non-Small-Cell Lung Carcinoma Cells
Cancer metabolism has greatly interested researchers. Mammalian target of rapamycin (mTOR) is dysregulated in a variety of… 
2014
2014
Benzofuran derivatives as a novel class of inhibitors of mTOR signaling.
2014
2014
Mudi, a web tool for identifying mutations by bioinformatics analysis of whole‐genome sequence
In forward genetics, identification of mutations is a time‐consuming and laborious process. Modern whole‐genome sequencing… 
2013
2013
A dual mTORC1 and mTORC2 inhibitor shows antitumor activity in esophageal squamous cell carcinoma cells and sensitizes them to cisplatin
The mammalian target of rapamycin (mTOR) signaling pathway is critical for the growth and proliferation of various malignant… 
2011
2011
Constitutive activation with overexpression of the mTORC2-phospholipase D1 pathway in uterine leiomyosarcoma and STUMP: morphoproteomic analysis with therapeutic implications.
The mammalian target of rapamycin (mTOR) is centrally involved in growth, survival and metabolism. In cancer, mTOR is frequently… 
Highly Cited
2010
Highly Cited
2010
A phase I dose-escalation study of the safety, pharmacokinetics (PK), and pharmacodynamics of XL765 (SAR245409), a PI3K/TORC1/TORC2 inhibitor administered orally to patients (pts) with advanced…
3030 Background: XL765 is a potent and selective inhibitor of class I PI3K isoforms, TORC1, and TORC2. XL765 has shown dose… 
2009
2009
Fed-state clamp stimulates cellular mechanisms of muscle protein anabolism and modulates glucose disposal in normal men.
Since maximum anabolism occurs postprandially, we developed a simulated fed state with clamped hyperinsulinemia, physiological… 
2008
2008
MHC class I and integrin ligation induce ERK activation via an mTORC2-dependent pathway.
2007
2007
Regulation of hypoxia-inducible factor 1 by glucose availability under hypoxic conditions.
Hypoxia-inducible transcription factor 1 (HIF-1), consisting of HIF-1 alpha and HIF-1 beta subunits, regulates the expression of… 
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