Skip to search form
Skip to main content
Skip to account menu
Semantic Scholar
Semantic Scholar's Logo
Search 227,741,300 papers from all fields of science
Search
Sign In
Create Free Account
mechanistic target of rapamycin complex 1
Known as:
TORC1
, Target of Rapamycin Complex 1
, mTORC1
Expand
A protein complex that is involved in the both serine/threonine phosphorylation and the regulation of protein synthesis in response to cellular…
Expand
National Institutes of Health
Create Alert
Alert
Related topics
Related topics
7 relations
DEP Domain-Containing mTOR-Interacting Protein
FRAP1 protein, human
MTOR gene
Serine/Threonine Phosphorylation
Expand
Broader (2)
FKBP12-rapamycin associated protein
Multiprotein Complexes
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
The yeast H+-ATPase Pma1 promotes Rag/Gtr-dependent TORC1 activation in response to H+-coupled nutrient uptake
E. Saliba
,
Minoas Evangelinos
,
Christos Gournas
,
F. Corrillon
,
I. Georis
,
B. André
eLife
2018
Corpus ID: 4148000
The yeast Target of Rapamycin Complex 1 (TORC1) plays a central role in controlling growth. How amino acids and other nutrients…
Expand
2015
2015
The TORC1-activated Proteins, p70S6K and GRB10, Regulate IL-4 Signaling and M2 Macrophage Polarization by Modulating Phosphorylation of Insulin Receptor Substrate-2*
K. Warren
,
Xi Fang
,
N. Gowda
,
Joshua J Thompson
,
N. Heller
Journal of Biological Chemistry
2015
Corpus ID: 21369945
Lung M2 macrophages are regulators of airway inflammation, associated with poor lung function in allergic asthma. Previously, we…
Expand
2013
2013
A dual mTORC1 and mTORC2 inhibitor shows antitumor activity in esophageal squamous cell carcinoma cells and sensitizes them to cisplatin
Yu Huang
,
Q. Xi
,
+4 authors
Shiying Yu
Anti-Cancer Drugs
2013
Corpus ID: 25649188
The mammalian target of rapamycin (mTOR) signaling pathway is critical for the growth and proliferation of various malignant…
Expand
2011
2011
Morphoproteomic analysis reveals an overexpressed and constitutively activated phospholipase D1-mTORC2 pathway in endometrial carcinoma.
Q. Shen
,
M. Stanton
,
+5 authors
Xiuzhen Duan
International Journal of Clinical and…
2011
Corpus ID: 32116113
The mammalian target of rapamycin (MTOR) assembles into two distinct complexes: mTOR complex 1 (mTORC1) is predominantly…
Expand
2011
2011
Constitutive activation with overexpression of the mTORC2-phospholipase D1 pathway in uterine leiomyosarcoma and STUMP: morphoproteomic analysis with therapeutic implications.
S. Dhingra
,
M. Rodriguez
,
+5 authors
Robert E. Brown
International Journal of Clinical and…
2011
Corpus ID: 6139727
The mammalian target of rapamycin (mTOR) is centrally involved in growth, survival and metabolism. In cancer, mTOR is frequently…
Expand
Highly Cited
2010
Highly Cited
2010
A phase I dose-escalation study of the safety, pharmacokinetics (PK), and pharmacodynamics of XL765 (SAR245409), a PI3K/TORC1/TORC2 inhibitor administered orally to patients (pts) with advanced…
I. Braña
,
P. LoRusso
,
+5 authors
K. Papadopoulos
2010
Corpus ID: 78797415
3030 Background: XL765 is a potent and selective inhibitor of class I PI3K isoforms, TORC1, and TORC2. XL765 has shown dose…
Expand
2009
2009
Fed-state clamp stimulates cellular mechanisms of muscle protein anabolism and modulates glucose disposal in normal men.
O. Adegoke
,
S. Chevalier
,
+5 authors
E. Marliss
American Journal of Physiology. Endocrinology and…
2009
Corpus ID: 25985775
Since maximum anabolism occurs postprandially, we developed a simulated fed state with clamped hyperinsulinemia, physiological…
Expand
2009
2009
A phase I dose-escalation study of the safety, pharmacokinetics (PK), and pharmacodynamics of XL765, a PI3K/TORC1/TORC2 inhibitor administered orally to patients (pts) with advanced solid tumors.
P. LoRusso
,
B. Markman
,
+5 authors
K. Papadopoulos
Journal of Clinical Oncology
2009
Corpus ID: 31252264
3502 Background: XL765 is a potent and selective inhibitor of Class I PI3K isoforms, TORC1, and TORC2. XL765 has shown dose…
Expand
2008
2008
MHC class I and integrin ligation induce ERK activation via an mTORC2-dependent pathway.
P. Jindra
,
Yi-Ping Jin
,
R. Jacamo
,
E. Rozengurt
,
E. Reed
Biochemical and Biophysical Research…
2008
Corpus ID: 39578996
2007
2007
Regulation of hypoxia-inducible factor 1 by glucose availability under hypoxic conditions.
Jing Zhou
,
K. Hara
,
+8 authors
K. Yokono
The Kobe journal of medical sciences
2007
Corpus ID: 23706228
Hypoxia-inducible transcription factor 1 (HIF-1), consisting of HIF-1 alpha and HIF-1 beta subunits, regulates the expression of…
Expand
By clicking accept or continuing to use the site, you agree to the terms outlined in our
Privacy Policy
(opens in a new tab)
,
Terms of Service
(opens in a new tab)
, and
Dataset License
(opens in a new tab)
ACCEPT & CONTINUE