FAQ

mechanistic target of rapamycin complex 1

Known as: TORC1, Target of Rapamycin Complex 1, mTORC1 
A protein complex that is involved in the both serine/threonine phosphorylation and the regulation of protein synthesis in response to cellular… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

2005-2017
02040608020052017

Related topics

Related topics

6 relations

Broader (2)

FKBP12-rapamycin associated proteinMultiprotein Complexes
FRAP1 protein, humanMTOR geneSerine/Threonine PhosphorylationTranslational Activation

Related mentions per year

Related mentions per year

1980-2018
19801990200020102020
mechanistic target of rapamycin complex 1
FRAP1 protein, human
Multiprotein Complexes
MTOR gene
Translational Activation
Serine/Threonine Phosphorylation

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2015
2015
Tuberous sclerosis complex 1-mechanistic target of rapamycin complex 1 signaling determines brown-to-white adipocyte phenotypic switch.
Interconversion of white and brown adipocytes occurs between anabolic and catabolic states. The molecular mechanism regulating… (More)
Is this relevant?
2014
2014
Hepatic signaling by the mechanistic target of rapamycin complex 2 (mTORC2).
The mechanistic target of rapamycin (mTOR) exists in two complexes that regulate diverse cellular processes. mTOR complex 1… (More)
  • figure 1
  • table 1
  • figure 2
  • table 2
  • table 3
Is this relevant?
2014
2014
Mechanistic target of rapamycin complex 1 expands Th17 and IL-4+ CD4-CD8- double-negative T cells and contracts regulatory T cells in systemic lupus erythematosus.
The mechanistic target of rapamycin (mTOR) is activated in CD4(-)CD8(-) double-negative (DN) T cells and its blockade is… (More)
Is this relevant?
2014
2014
Mechanistic target of rapamycin complex 1 is critical for invariant natural killer T-cell development and effector function.
The mechanisms that control invariant natural killer T (iNKT)-cell development and function are still poorly understood. The… (More)
Is this relevant?
Highly Cited
2012
Highly Cited
2012
A unifying model for mTORC1-mediated regulation of mRNA translation
The mTOR complex 1 (mTORC1) kinase nucleates a pathway that promotes cell growth and proliferation and is the target of rapamycin… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
Is this relevant?
Highly Cited
2012
Highly Cited
2012
A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB
The lysosome plays a key role in cellular homeostasis by controlling both cellular clearance and energy production to respond to… (More)
  • figure 1
  • figure 3
  • figure 4
  • figure 5
  • figure 6
Is this relevant?
Highly Cited
2011
Highly Cited
2011
mTOR Complex 1 Regulates Lipin 1 Localization to Control the SREBP Pathway
The nutrient- and growth factor-responsive kinase mTOR complex 1 (mTORC1) regulates many processes that control growth, including… (More)
Is this relevant?
Highly Cited
2011
Highly Cited
2011
mTORC1 senses lysosomal amino acids through an inside-out mechanism that requires the vacuolar H(+)-ATPase.
The mTOR complex 1 (mTORC1) protein kinase is a master growth regulator that is stimulated by amino acids. Amino acids activate… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
Is this relevant?
Highly Cited
2009
Highly Cited
2009
Biochemical, cellular, and in vivo activity of novel ATP-competitive and selective inhibitors of the mammalian target of rapamycin.
The mammalian target of rapamycin (mTOR) is centrally involved in cell growth, metabolism, and angiogenesis. While showing… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
2008
Highly Cited
2008
The role of hypothalamic mammalian target of rapamycin complex 1 signaling in diet-induced obesity.
The mammalian target of rapamycin (mTOR) kinase is a key regulator of several cellular functions, including cell growth and… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?