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mechanistic target of rapamycin complex 1

Known as: TORC1, Target of Rapamycin Complex 1, mTORC1 
A protein complex that is involved in the both serine/threonine phosphorylation and the regulation of protein synthesis in response to cellular… 
National Institutes of Health

Related topics

Related topics

7 relations
DEP Domain-Containing mTOR-Interacting ProteinFRAP1 protein, humanMTOR geneSerine/Threonine Phosphorylation

Broader (2)

FKBP12-rapamycin associated proteinMultiprotein Complexes

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
The yeast H+-ATPase Pma1 promotes Rag/Gtr-dependent TORC1 activation in response to H+-coupled nutrient uptake
The yeast Target of Rapamycin Complex 1 (TORC1) plays a central role in controlling growth. How amino acids and other nutrients… 
2015
2015
The TORC1-activated Proteins, p70S6K and GRB10, Regulate IL-4 Signaling and M2 Macrophage Polarization by Modulating Phosphorylation of Insulin Receptor Substrate-2*
Lung M2 macrophages are regulators of airway inflammation, associated with poor lung function in allergic asthma. Previously, we… 
2013
2013
A dual mTORC1 and mTORC2 inhibitor shows antitumor activity in esophageal squamous cell carcinoma cells and sensitizes them to cisplatin
The mammalian target of rapamycin (mTOR) signaling pathway is critical for the growth and proliferation of various malignant… 
2011
2011
Morphoproteomic analysis reveals an overexpressed and constitutively activated phospholipase D1-mTORC2 pathway in endometrial carcinoma.
The mammalian target of rapamycin (MTOR) assembles into two distinct complexes: mTOR complex 1 (mTORC1) is predominantly… 
2011
2011
Constitutive activation with overexpression of the mTORC2-phospholipase D1 pathway in uterine leiomyosarcoma and STUMP: morphoproteomic analysis with therapeutic implications.
The mammalian target of rapamycin (mTOR) is centrally involved in growth, survival and metabolism. In cancer, mTOR is frequently… 
Highly Cited
2010
Highly Cited
2010
A phase I dose-escalation study of the safety, pharmacokinetics (PK), and pharmacodynamics of XL765 (SAR245409), a PI3K/TORC1/TORC2 inhibitor administered orally to patients (pts) with advanced…
3030 Background: XL765 is a potent and selective inhibitor of class I PI3K isoforms, TORC1, and TORC2. XL765 has shown dose… 
2009
2009
Fed-state clamp stimulates cellular mechanisms of muscle protein anabolism and modulates glucose disposal in normal men.
Since maximum anabolism occurs postprandially, we developed a simulated fed state with clamped hyperinsulinemia, physiological… 
2009
2009
A phase I dose-escalation study of the safety, pharmacokinetics (PK), and pharmacodynamics of XL765, a PI3K/TORC1/TORC2 inhibitor administered orally to patients (pts) with advanced solid tumors.
3502 Background: XL765 is a potent and selective inhibitor of Class I PI3K isoforms, TORC1, and TORC2. XL765 has shown dose… 
2008
2008
MHC class I and integrin ligation induce ERK activation via an mTORC2-dependent pathway.
2007
2007
Regulation of hypoxia-inducible factor 1 by glucose availability under hypoxic conditions.
Hypoxia-inducible transcription factor 1 (HIF-1), consisting of HIF-1 alpha and HIF-1 beta subunits, regulates the expression of… 
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