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Mitogenic signaling pathways induced by G protein‐coupled receptors
  • E. Rozengurt
  • Biology, Medicine
  • Journal of cellular physiology
  • 1 December 2007
Recent advances in defining the pathways that play a role in transducing mitogenic responses induced by GPCR agonists are reviewed. Expand
Protein Kinase D Signaling*
Protein kinase D (PKD), the founding member of a new family of serine/threonine protein kinases and the subject of this minireview, occupies a unique position in the signal transduction pathways initiated by DAG and PKC. Expand
Molecular cloning and characterization of protein kinase D: a target for diacylglycerol and phorbol esters with a distinctive catalytic domain.
The bacterially expressed catalytic domain of PKD efficiently phosphorylated the exogenous peptide substrate syntide 2 in serine but did not catalyze significant phosphorylation of a variety of other substrates used by PKCs and other major second messenger regulated kinases. Expand
Expression of bitter taste receptors of the T2R family in the gastrointestinal tract and enteroendocrine STC-1 cells
The expression of bitter taste receptors of the T2R family in the mouse and rat gastrointestinal tract is demonstrated using reverse transcriptase–PCR and DNA sequencing, immunohistochemistry, and Western blotting. Expand
Early signals in the mitogenic response.
Polypeptide growth factors, regulatory peptides, and a variety of pharmacological agents acting alone or synergistically induce mitogenesis in cultured fibroblasts are integrated in a unified hypothesis for the regulation of fibroblast growth. Expand
Protein kinase D signaling: multiple biological functions in health and disease.
Studies on PKD thus far indicate a striking diversity of both its signal generation and distribution and its potential for complex regulatory interactions with multiple downstream pathways, often regulating the subcellular localization of its targets. Expand
Colocalization of the alpha-subunit of gustducin with PYY and GLP-1 in L cells of human colon.
Galpha(gust) and chemosensory receptors that perceive chemical components of ingested substances, including drugs and toxins, in open enteroendocrine L cells has important implications for understanding molecular sensing in the human GI tract and for developing novel therapeutic compounds that modify the function of these receptors in the gut. Expand
Identification and Cloning of Kidins220, a Novel Neuronal Substrate of Protein Kinase D*
It is shown that Kidins220 is an integral membrane protein selectively expressed in brain and neuroendocrine cells, where it concentrates at the tip of neurites and is phosphorylated by PKD at serine 919 in vivo. Expand
Bitter stimuli induce Ca2+ signaling and CCK release in enteroendocrine STC-1 cells: role of L-type voltage-sensitive Ca2+ channels.
It is demonstrated that bitter tastants increase [Ca(2+)](i) and cholecystokinin release through Ca(2+) influx mediated by the opening of L-type VSCCs in enteroendocrine STC-1 cells. Expand
Enteroendocrine cells: a site of ‘taste’ in gastrointestinal chemosensing
The role of enteroendocrine cells of the gastrointestinal tract as chemoreceptors that sense lumen contents and induce changes in gastrointestinal function and food intake through the release of signaling substances acting on a variety of targets locally or at a distance is discussed. Expand