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Serine/Threonine Phosphorylation

Serine/Threonine Phosphorylation involves covalent linkage of a phosphate group (from a donor compound such as ATP) with a serine or threonine… 
National Institutes of Health

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50 relations
ACVR1 protein, humanACVR1B wt AlleleACVR2A geneACVR2B gene

Papers overview

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Highly Cited
2002
Highly Cited
2002
Control of beta-catenin phosphorylation/degradation by a dual-kinase mechanism.
Wnt regulation of beta-catenin degradation is essential for development and carcinogenesis. beta-catenin degradation is initiated… 
Review
2002
Review
2002
14-3-3 Proteins: Active Cofactors in Cellular Regulation by Serine/Threonine Phosphorylation*
The 14-3-3 proteins are a family of abundant, widely expressed 28–33-kDa acidic polypeptides that spontaneously self-assemble as… 
Highly Cited
2001
Highly Cited
2001
Serine/threonine phosphorylation of IRS-1 triggers its degradation: possible regulation by tyrosine phosphorylation.
Insulin receptor substrate (IRS)-1 protein expression is markedly reduced in many insulin-resistant states, although the… 
Highly Cited
2000
Highly Cited
2000
A rapamycin-sensitive pathway down-regulates insulin signaling via phosphorylation and proteasomal degradation of insulin receptor substrate-1.
Insulin receptor substrate-1 (IRS-1) is a major substrate of the insulin receptor and acts as a docking protein for Src homology… 
Highly Cited
1998
Highly Cited
1998
Activation of the beta-catenin gene in primary hepatocellular carcinomas by somatic alterations involving exon 3.
We screened 75 primary hepatocellular carcinomas for somatic mutations in the entire coding region of the beta-catenin gene. We… 
Highly Cited
1996
Highly Cited
1996
Phosphorylation of Insulin Receptor Substrate-1 on Multiple Serine Residues, 612, 632, 662, and 731, Modulates Insulin Action (*)
Okadaic acid has been described previously as being a negative regulator of insulin signaling, as it inhibits insulin stimulation… 
Highly Cited
1994
Highly Cited
1994
Glycogen synthase kinase-3 beta is a dual specificity kinase differentially regulated by tyrosine and serine/threonine phosphorylation.
The enzyme glycogen synthase kinase-3 (GSK-3) has been implicated in the control of several metabolic enzymes and transcription… 
Highly Cited
1994
Highly Cited
1994
Serine/threonine phosphorylation of insulin receptor substrate 1 modulates insulin receptor signaling.
Highly Cited
1992
Highly Cited
1992
Xenopus MAP kinase activator is a serine/threonine/tyrosine kinase activated by threonine phosphorylation.
Xenopus MAP kinase activator, a 45 kDa protein, has been shown to function as a direct upstream factor sufficient for full… 
Review
1988
Review
1988
Insulin receptor signaling. Activation of multiple serine kinases.
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