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Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes
- A. Guilherme, J. Virbasius, V. Puri, M. Czech
- Biology, MedicineNature Reviews Molecular Cell Biology
- 1 May 2008
It is postulate that this variability in the severity of insulin resistance varies greatly among obese people might reflect differences in levels of lipid-droplet proteins that promote the sequestration of fatty acids within adipocytes in the form of triglycerides, thereby lowering exposure of skeletal muscle to the inhibitory effects of fatty acid.
The GLUT4 glucose transporter.
Mitochondrial remodeling in adipose tissue associated with obesity and treatment with rosiglitazone.
- Leanne Wilson-Fritch, Sarah M Nicoloro, S. Corvera
- BiologyThe Journal of clinical investigation
- 1 November 2004
Adipose tissue plays a central role in the control of energy homeostasis through the storage and turnover of triglycerides and through the secretion of factors that affect satiety and fuel…
Local proliferation of macrophages contributes to obesity-associated adipose tissue inflammation.
Orally delivered siRNA targeting macrophage Map4k4 suppresses systemic inflammation
The engineering of β1,3-d-glucan-encapsulated siRNA particles (GeRPs) are reported as efficient oral delivery vehicles that potently silence genes in mouse macrophages in vitro and in vivo, defining a new strategy for oral delivery of siRNA to attenuate inflammatory responses in human disease.
Mitochondrial Biogenesis and Remodeling during Adipogenesis and in Response to the Insulin Sensitizer Rosiglitazone
- Leanne Wilson-Fritch, Alison M. Burkart, S. Corvera
- BiologyMolecular and Cellular Biology
- 1 February 2003
The results reveal that mitochondrial biogenesis and remodeling are inherent to adipose differentiation per se and are influenced by the actions of insulin sensitizers.
PIP2 and PIP3 Complex Roles at the Cell Surface
- M. Czech
- 17 March 2000
EHD2 and the Novel EH Domain Binding Protein EHBP1 Couple Endocytosis to the Actin Cytoskeleton*
Two novel proteins denoted EH domain protein 2 (EHD2) and EHD2-binding protein 1 (EHBP1) that link clathrin-mediated endocytosis to the actin cytoskeleton are identified.
Insulin action and resistance in obesity and type 2 diabetes
- M. Czech
- Medicine, BiologyNature Medicine
- 1 July 2017
This Perspective reviews alternate viewpoints and recent results on the temporal and mechanistic connections between hyperinsulinemia, obesity and insulin resistance and connects insulin resistance to extensive metabolic cross-talk between the liver, adipose tissue, pancreas and skeletal muscle.