• Publications
  • Influence
Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes
Acquired resistance to the action of insulin to stimulate glucose transport in skeletal muscle is associated with obesity and promotes the development of type 2 diabetes. In skeletal muscle, insulinExpand
The GLUT4 glucose transporter.
Few physiological parameters are more tightly and acutely regulated in humans than blood glucose concentration. The major cellular mechanism that diminishes blood glucose when carbohydrates areExpand
Mitochondrial remodeling in adipose tissue associated with obesity and treatment with rosiglitazone.
Adipose tissue plays a central role in the control of energy homeostasis through the storage and turnover of triglycerides and through the secretion of factors that affect satiety and fuelExpand
Local proliferation of macrophages contributes to obesity-associated adipose tissue inflammation.
Adipose tissue (AT) of obese mice and humans accumulates immune cells, which secrete cytokines that can promote insulin resistance. AT macrophages (ATMs) are thought to originate fromExpand
Orally delivered siRNA targeting macrophage Map4k4 suppresses systemic inflammation
Gene silencing by double-stranded RNA, denoted RNA interference, represents a new paradigm for rational drug design. However, the transformative therapeutic potential of short interfering RNA (siRNA)Expand
Mitochondrial Biogenesis and Remodeling during Adipogenesis and in Response to the Insulin Sensitizer Rosiglitazone
ABSTRACT White adipose tissue is an important endocrine organ involved in the control of whole-body metabolism, insulin sensitivity, and food intake. To better understand these functions, 3T3-L1 cellExpand
Structural basis and mechanism of autoregulation in 3-phosphoinositide-dependent Grp1 family Arf GTPase exchange factors.
Arf GTPases regulate membrane trafficking and actin dynamics. Grp1, ARNO, and Cytohesin-1 comprise a family of phosphoinositide-dependent Arf GTPase exchange factors with a Sec7-pleckstrin homologyExpand
EHD2 and the Novel EH Domain Binding Protein EHBP1 Couple Endocytosis to the Actin Cytoskeleton*
Here we identified two novel proteins denoted EH domain protein 2 (EHD2) and EHD2-binding protein 1 (EHBP1) that link clathrin-mediated endocytosis to the actin cytoskeleton. EHD2 contains anExpand
A Comparative Analysis of the Phosphoinositide Binding Specificity of Pleckstrin Homology Domains*
Pleckstrin homology (PH) and phosphotyrosine binding (PTB) domains are structurally related regulatory modules that are present in a variety of proteins involved in signal transduction, such asExpand
PIP2 and PIP3 Complex Roles at the Cell Surface
  • M. Czech
  • Biology, Medicine
  • Cell
  • 17 March 2000
of pleckstrin homology (PH) domains that bind selectively to these phosphoinositides (Kavran et al., 1998). Worcester, Massachusetts 01605 PH domains have been identified in over 100 proteins, manyExpand