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ACVR2B gene

Known as: ACTIVIN A RECEPTOR, TYPE IIB, Activin A Receptor, Type IIB Gene, ACVR2B 
This gene plays a role in the transforming growth factor-beta signal transduction pathway and is essential for ligand binding and kinase activity.
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2010
Highly Cited
2010
Muscle wasting and cachexia have long been postulated to be key determinants of cancer-related death, but there has been no… Expand
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Highly Cited
2003
Highly Cited
2003
ABSTRACT Myostatin, a transforming growth factor β (TGF-β) family member, is a potent negative regulator of skeletal muscle… Expand
Highly Cited
2003
Highly Cited
2003
The TGF‐β superfamily of ligands and receptors stimulate cellular events in diverse processes ranging from cell fate… Expand
Highly Cited
2002
Highly Cited
2002
Background: Two TGFβ‐related proteins, Nodal and Lefty, are implicated in early embryonic patterning of vertebrates. Genetic data… Expand
Highly Cited
2001
Highly Cited
2001
Nodal proteins have crucial roles in mesendoderm formation and left-right patterning during vertebrate development. The molecular… Expand
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Highly Cited
2000
Highly Cited
2000
Foregut development produces a characteristic sequence of gastrointestinal and respiratory organs, but the signaling pathways… Expand
Highly Cited
1999
Highly Cited
1999
Endoglin (CD105) is a transmembrane glycoprotein that binds transforming growth factor (TGF)-β1 and -β3, and coprecipitates with… Expand
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Highly Cited
1997
Highly Cited
1997
Vertebrate animals exhibit segmented axial skeletons and lateral asymmetry of the visceral organs. The segment identity of… Expand
Highly Cited
1995
Highly Cited
1995
Proteins in the TGF-beta superfamily transduce their effects through binding to type I and type II serine/threonine kinase… Expand
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Highly Cited
1994
Highly Cited
1994
We recently demonstrated that inhibin/activin alpha-, beta A-, and beta B-subunit messenger RNAs (mRNAs) are localized in a… Expand