FAQ

ACVR2B gene

Known as: ACTIVIN A RECEPTOR, TYPE IIB, Activin A Receptor, Type IIB Gene, ACVR2B 
This gene plays a role in the transforming growth factor-beta signal transduction pathway and is essential for ligand binding and kinase activity.
National Institutes of Health

Topic mentions per year

Topic mentions per year

1993-2018
05101519932018

Related topics

Related topics

9 relations
ACVR2B protein, humanACVR2B wt AlleleLigand BindingPattern Formation
(More)

Related mentions per year

Related mentions per year

1938-2018
19401960198020002020
ACVR2B gene
Signal Transduction
Phosphorylation
Ligand Binding
Receptor Signaling
Serine/Threonine Phosphorylation

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2010
Highly Cited
2010
Reversal of Cancer Cachexia and Muscle Wasting by ActRIIB Antagonism Leads to Prolonged Survival
Muscle wasting and cachexia have long been postulated to be key determinants of cancer-related death, but there has been no… (More)
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Highly Cited
2010
Highly Cited
2010
Acute inhibition of myostatin-family proteins preserves skeletal muscle in mouse models of cancer cachexia.
Cachexia, progressive loss of fat and muscle mass despite adequate nutrition, is a devastating complication of cancer associated… (More)
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Highly Cited
2008
Highly Cited
2008
Hemojuvelin regulates hepcidin expression via a selective subset of BMP ligands and receptors independently of neogenin.
Hemojuvelin (HJV) is a coreceptor for bone morphogenetic protein (BMP) signaling that regulates hepcidin expression and iron… (More)
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2007
2007
Distinct and cooperative roles of mammalian Vg1 homologs GDF1 and GDF3 during early embryonic development.
Vg1, a member of the TGF-beta superfamily of ligands, has been implicated in the induction of mesoderm, formation of primitive… (More)
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Highly Cited
2004
Highly Cited
2004
Bone morphogenetic protein (BMP) ligands and receptors in bovine ovarian follicle cells: actions of BMP-4, -6 and -7 on granulosa cells and differential modulation of Smad-1 phosphorylation by…
Given the paucity of information on the potential roles of bone morphogenetic proteins (BMPs) in the ruminant ovary we conducted… (More)
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Highly Cited
2003
Highly Cited
2003
Myostatin signals through a transforming growth factor beta-like signaling pathway to block adipogenesis.
Myostatin, a transforming growth factor beta (TGF-beta) family member, is a potent negative regulator of skeletal muscle growth… (More)
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Highly Cited
2002
Highly Cited
2002
Activin type IIA and IIB receptors mediate Gdf11 signaling in axial vertebral patterning.
Vertebral bodies are segmented along the anteroposterior (AP) body axis, and the segmental identity of the vertebrae is… (More)
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Highly Cited
2001
Highly Cited
2001
The orphan receptor ALK7 and the Activin receptor ALK4 mediate signaling by Nodal proteins during vertebrate development.
Nodal proteins have crucial roles in mesendoderm formation and left-right patterning during vertebrate development. The molecular… (More)
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Highly Cited
1999
Highly Cited
1999
Endoglin is an accessory protein that interacts with the signaling receptor complex of multiple members of the transforming growth factor-beta superfamily.
Endoglin (CD105) is a transmembrane glycoprotein that binds transforming growth factor (TGF)-beta1 and -beta3, and coprecipitates… (More)
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Highly Cited
1997
Highly Cited
1997
The signaling pathway mediated by the type IIB activin receptor controls axial patterning and lateral asymmetry in the mouse.
Vertebrate animals exhibit segmented axial skeletons and lateral asymmetry of the visceral organs. The segment identity of… (More)
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