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ACVR2B gene

Known as: ACTIVIN A RECEPTOR, TYPE IIB, Activin A Receptor, Type IIB Gene, ACVR2B 
This gene plays a role in the transforming growth factor-beta signal transduction pathway and is essential for ligand binding and kinase activity.
National Institutes of Health

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9 relations
ACVR2B protein, humanACVR2B wt AlleleLigand BindingPattern Formation

Papers overview

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Highly Cited
2010
Highly Cited
2010
Reversal of Cancer Cachexia and Muscle Wasting by ActRIIB Antagonism Leads to Prolonged Survival
Review
2009
Review
2009
The biology of activin: recent advances in structure, regulation and function.
Activin was discovered in the 1980s as a gonadal protein that stimulated FSH release from pituitary gonadotropes and was thought… 
Highly Cited
2003
Highly Cited
2003
Structures of an ActRIIB:activin A complex reveal a novel binding mode for TGF‐β ligand:receptor interactions
The TGF‐β superfamily of ligands and receptors stimulate cellular events in diverse processes ranging from cell fate… 
Highly Cited
2002
Highly Cited
2002
Inhibition of Nodal signalling by Lefty mediated through interaction with common receptors and efficient diffusion
Background: Two TGFβ‐related proteins, Nodal and Lefty, are implicated in early embryonic patterning of vertebrates. Genetic data… 
Highly Cited
2001
Highly Cited
2001
The orphan receptor ALK7 and the Activin receptor ALK4 mediate signaling by Nodal proteins during vertebrate development.
Nodal proteins have crucial roles in mesendoderm formation and left-right patterning during vertebrate development. The molecular… 
Highly Cited
2000
Highly Cited
2000
Activin receptor patterning of foregut organogenesis.
Foregut development produces a characteristic sequence of gastrointestinal and respiratory organs, but the signaling pathways… 
Highly Cited
1999
Highly Cited
1999
Endoglin Is an Accessory Protein That Interacts with the Signaling Receptor Complex of Multiple Members of the Transforming Growth Factor-β Superfamily*
Endoglin (CD105) is a transmembrane glycoprotein that binds transforming growth factor (TGF)-β1 and -β3, and coprecipitates with… 
Highly Cited
1997
Highly Cited
1997
The signaling pathway mediated by the type IIB activin receptor controls axial patterning and lateral asymmetry in the mouse.
Vertebrate animals exhibit segmented axial skeletons and lateral asymmetry of the visceral organs. The segment identity of… 
Highly Cited
1995
Highly Cited
1995
Osteogenic protein-1 binds to activin type II receptors and induces certain activin-like effects
Proteins in the TGF-beta superfamily transduce their effects through binding to type I and type II serine/threonine kinase… 
Highly Cited
1994
Highly Cited
1994
Expression of messenger ribonucleic acids encoding the inhibin/activin system during mid- and late-gestation rat embryogenesis.
We recently demonstrated that inhibin/activin alpha-, beta A-, and beta B-subunit messenger RNAs (mRNAs) are localized in a… 
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