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Growth differentiation factor-9 is required during early ovarian folliculogenesis
TLDR
Oocyte growth and zona pellucida formation proceed normally, but other aspects of oocyte differentiation are compromised, and GDF-9 is the first oocyte-derived growth factor required for somatic cell function in vivo. Expand
Math1 is essential for genesis of cerebellar granule neurons
TLDR
It is reported that mice lacking Math1 fail to form granule cells and are born with a cerebellum that is devoid of an external germinal layer, the first gene to be shown to be required in vivo for the genesis of granules cells, and hence the predominant neuronal population in the cerebellums. Expand
Social amnesia in mice lacking the oxytocin gene
TLDR
The data indicate that OT is necessary for the normal development of social memory in mice and support the hypothesis that social memory has a neural basis distinct from other forms of memory. Expand
Paracrine actions of growth differentiation factor-9 in the mammalian ovary.
TLDR
In addition to playing a critical function as a growth and differentiation factor during early folliculogenesis, GDF-9 functions as an oocyte-secreted paracrine factor to regulate several key granulosa cell enzymes involved in cumulus expansion and maintenance of an optimal oocyte microenvironment, processes which are essential for normal ovulation, fertilization, and female reproduction. Expand
NOBOX Deficiency Disrupts Early Folliculogenesis and Oocyte-Specific Gene Expression
TLDR
It is shown that lack of Nobox, an oocyte-specific homeobox gene, accelerates postnatal oocyte loss and abolishes the transition from primordial to growing follicles in mice, essential for postnatal follicle development. Expand
Follistatin operates downstream of Wnt4 in mammalian ovary organogenesis
  • H. Yao, M. Matzuk, +4 authors B. Capel
  • Biology, Medicine
  • Developmental dynamics : an official publication…
  • 1 June 2004
TLDR
This work shows that follistatin (Fst), which encodes a TGFβ superfamily binding protein, is a downstream component of Wnt4 signaling and proposes that WNT4 acts through FST to regulate vascular boundaries and maintain germ cell survival in the ovary. Expand
Pervasive social deficits, but normal parturition, in oxytocin receptor-deficient mice.
TLDR
It is demonstrated that OXTR plays a critical role in regulating several aspects of social behavior and may have important implications for developmental psychiatric disorders characterized by deficits in social behavior. Expand
Human cumulus granulosa cell gene expression: a predictor of fertilization and embryo selection in women undergoing IVF.
TLDR
PTGS2, HAS2 and GREM1 gene expression correlates to morphological and physiological characteristics and provides a novel approach to predict human embryo development, reducing higher order pregnancy rates. Expand
Follicle stimulating hormone is required for ovarian follicle maturation but not male fertility
TLDR
To generate animal models for human diseases involving the gonadotropin signal transduction pathway, mice deficient in the FSHβ subunit are produced and therefore in FSH using ES cell technology. Expand
Synergistic roles of bone morphogenetic protein 15 and growth differentiation factor 9 in ovarian function.
TLDR
The dosage of intact Bmp15 and Gdf9 alleles directly influences the destiny of the oocyte during folliculogenesis and in the periovulatory period, which has important implications for human fertility control and the maintenance of fertility and normal ovarian physiology. Expand
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