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Ligand Binding
Ligand Binding is the tight and specific (high affinity) interaction between a small molecule (typically) and a macromolecule (usually protein) that…
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National Institutes of Health
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Related topics
Related topics
50 relations
ABCG2 wt Allele
ADORA2B protein, human
AMIGO2 protein, human
BRS3 gene
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Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2016
Highly Cited
2016
Regulation of protein-ligand binding affinity by hydrogen bond pairing
Deliang Chen
,
N. Oezguen
,
P. Urvil
,
Colin Ferguson
,
Sara M. Dann
,
T. Savidge
Science Advances
2016
Corpus ID: 1201246
Receptor-ligand H-bond pairings have evolved to promote high-affinity binding by reducing competitive interference with water…
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Review
2011
Review
2011
The pro- and anti-inflammatory properties of the cytokine interleukin-6.
J. Scheller
,
A. Chalaris
,
D. Schmidt-Arras
,
S. Rose-John
Biochimica et Biophysica Acta
2011
Corpus ID: 34373989
Highly Cited
2005
Highly Cited
2005
Structural basis for inhibition of the epidermal growth factor receptor by cetuximab.
Shiqing Li
,
K. R. Schmitz
,
P. Jeffrey
,
Jed J. W. Wiltzius
,
P. Kussie
,
K. Ferguson
Cancer Cell
2005
Corpus ID: 15943796
Highly Cited
2003
Highly Cited
2003
Fluorescence resonance energy transfer between quantum dot donors and dye-labeled protein acceptors.
A. R. Clapp
,
Igor L. Medintz
,
J. Mauro
,
B. Fisher
,
M. Bawendi
,
H. Mattoussi
Journal of the American Chemical Society
2003
Corpus ID: 1839731
We used luminescent CdSe-ZnS core-shell quantum dots (QDs) as energy donors in fluorescent resonance energy transfer (FRET…
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Highly Cited
1998
Highly Cited
1998
Crystallographic comparison of the estrogen and progesterone receptor's ligand binding domains.
D. Tanenbaum
,
Yong Wang
,
Shawn P. Williams
,
P. Sigler
Proceedings of the National Academy of Sciences…
1998
Corpus ID: 12972991
The 2.8-A crystal structure of the complex formed by estradiol and the human estrogen receptor-alpha ligand binding domain…
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Highly Cited
1998
Highly Cited
1998
The hemochromatosis gene product complexes with the transferrin receptor and lowers its affinity for ligand binding.
J. Feder
,
D. Penny
,
+7 authors
R. Schatzman
Proceedings of the National Academy of Sciences…
1998
Corpus ID: 6497919
We recently reported the positional cloning of a candidate gene for hereditary hemochromatosis called HFE. The gene product, a…
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Review
1997
Review
1997
The biology of vascular endothelial growth factor.
N. Ferrara
,
T. Davis-Smyth
Endocrine reviews
1997
Corpus ID: 36469601
The establishment of a vascular supply is required for organ development and differentiation as well as for tissue repair and…
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Highly Cited
1997
Highly Cited
1997
Integrin-ligand binding properties govern cell migration speed through cell-substratum adhesiveness
Sean P. Palecek
,
J. Loftus
,
M. Ginsberg
,
D. Lauffenburger
,
A. Horwitz
Nature
1997
Corpus ID: 4303770
Migration of cells in higher organisms is mediated by adhesion receptors, such as integrins, that link the cell to extracellular…
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Review
1990
Review
1990
Structure and ligand binding properties of human serum albumin.
U. Kragh‐Hansen
Danish medical bulletin
1990
Corpus ID: 32897166
UNLABELLED 1. INTRODUCTION Serum albumin possesses a unique capability to bind, covalently or reversibly, a great number of…
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Highly Cited
1988
Highly Cited
1988
Structure and energetics of ligand binding to proteins: Escherichia coli dihydrofolate reductase‐trimethoprim, a drug‐receptor system
P. Dauber-Osguthorpe
,
V. Roberts
,
D. Osguthorpe
,
Jon Wolff
,
Moniqe Genest
,
A. Hagler
Proteins: Structure, Function, and Bioinformatics
1988
Corpus ID: 2845395
A study of the binding of the antibacterial agent trimethoprim to Escherichia coli dihydrofolate reductase was carried out using…
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