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Ligand Binding

Ligand Binding is the tight and specific (high affinity) interaction between a small molecule (typically) and a macromolecule (usually protein) that… 
National Institutes of Health

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Related topics

50 relations
ABCG2 wt AlleleADORA2B protein, humanAMIGO2 protein, humanBRS3 gene

Papers overview

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Highly Cited
2009
Highly Cited
2009
Predicting Protein Ligand Binding Sites by Combining Evolutionary Sequence Conservation and 3D Structure
Identifying a protein's functional sites is an important step towards characterizing its molecular function. Numerous structure… 
Review
2008
Review
2008
Flexible ligand docking to multiple receptor conformations: a practical alternative.
Highly Cited
2005
Highly Cited
2005
Pocketome via Comprehensive Identification and Classification of Ligand Binding Envelopes*
We developed a new computational algorithm for the accurate identification of ligand binding envelopes rather than surface… 
Review
2002
Review
2002
Ligand-Induced, Receptor-Mediated Dimerization and Activation of EGF Receptor
Highly Cited
2000
Highly Cited
2000
Translating biomolecular recognition into nanomechanics.
We report the specific transduction, via surface stress changes, of DNA hybridization and receptor-ligand binding into a direct… 
Highly Cited
1998
Highly Cited
1998
Crystallographic comparison of the estrogen and progesterone receptor's ligand binding domains.
The 2.8-A crystal structure of the complex formed by estradiol and the human estrogen receptor-alpha ligand binding domain… 
Highly Cited
1993
Highly Cited
1993
Chimaeric nicotinic–serotonergic receptor combines distinct ligand binding and channel specificities
THE neuronal nicotinic α7 (nAChR) and 5-hydroxytryptamine (5HT3) receptors1–3 are ligand-gated ion channels with a homologous… 
Review
1990
Review
1990
Structure and ligand binding properties of human serum albumin.
UNLABELLED 1. INTRODUCTION Serum albumin possesses a unique capability to bind, covalently or reversibly, a great number of… 
Highly Cited
1990
Highly Cited
1990
A beta 3 integrin mutation abolishes ligand binding and alters divalent cation-dependent conformation.
The ligand-binding function of integrin adhesion receptors depends on divalent cations. A mutant alpha IIb beta 3 integrin… 
Highly Cited
1980
Highly Cited
1980
A quantitative analysis of beta-adrenergic receptor interactions: resolution of high and low affinity states of the receptor by computer modeling of ligand binding data.
The properties of ligand binding to the beta-adrenergic receptor have been studied using a computer modeling technique to analyze… 
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