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Ligand Binding

Ligand Binding is the tight and specific (high affinity) interaction between a small molecule (typically) and a macromolecule (usually protein) that… Expand
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2018
Review
2018
Underpinning all drug discovery projects is the interaction between a drug and its target, usually a protein. Thus, improved… Expand
Review
2017
Review
2017
  • A. Grove
  • Computational and structural biotechnology…
  • 2017
  • Corpus ID: 30603789
Bacteria have evolved sophisticated mechanisms for regulation of metabolic pathways. Such regulatory circuits ensure that… Expand
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Highly Cited
2005
Highly Cited
2005
We developed a new computational algorithm for the accurate identification of ligand binding envelopes rather than surface… Expand
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Highly Cited
2004
Highly Cited
2004
We used luminescent CdSe-ZnS core-shell quantum dots (QDs) as energy donors in fluorescent resonance energy transfer (FRET… Expand
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Review
2002
Review
2002
The EGF receptor mediates many cellular responses in normal biological processes and in pathological states. Recent structural… Expand
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Highly Cited
1998
Highly Cited
1998
We recently reported the positional cloning of a candidate gene for hereditary hemochromatosis called HFE. The gene product, a… Expand
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Highly Cited
1998
Highly Cited
1998
The 2.8-A crystal structure of the complex formed by estradiol and the human estrogen receptor-alpha ligand binding domain… Expand
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Review
1997
Review
1997
The establishment of a vascular supply is required for organ development and differentiation as well as for tissue repair and… Expand
Highly Cited
1997
Highly Cited
1997
Migration of cells in higher organisms is mediated by adhesion receptors, such as integrins, that link the cell to extracellular… Expand
Highly Cited
1988
Highly Cited
1988
A study of the binding of the antibacterial agent trimethoprim to Escherichia coli dihydrofolate reductase was carried out using… Expand