Ligand Binding

Ligand Binding is the tight and specific (high affinity) interaction between a small molecule (typically) and a macromolecule (usually protein) that… (More)

Topic mentions per year

Topic mentions per year

1977-2018
020406019772018

Papers overview

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2011
2011
Analysis of the experimental binding thermodynamics for approximately 100 protein-ligand complexes provides important insights… (More)
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Highly Cited
2009
Highly Cited
2009
Identifying a protein's functional sites is an important step towards characterizing its molecular function. Numerous structure… (More)
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Highly Cited
2005
Highly Cited
2005
Inhibitory glycine receptors (GlyRs) regulate motor coordination and sensory signal processing in spinal cord and other brain… (More)
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Highly Cited
2004
Highly Cited
2004
Ionotropic glutamate receptors are tetramers, the isolated ligand binding cores of which assemble as dimers. Previous work on… (More)
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Highly Cited
2002
Highly Cited
2002
Transcriptional regulation by the glucocorticoid receptor (GR) is mediated by hormone binding, receptor dimerization, and… (More)
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Highly Cited
2000
Highly Cited
2000
Crystal structures of the GluR2 ligand binding core (S1S2) have been determined in the apo state and in the presence of the… (More)
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Highly Cited
2000
Highly Cited
2000
In the Escherichia coli chemosensory pathway, receptor modification mediates adaptation to ligand. Evidence is presented that… (More)
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Highly Cited
1999
Highly Cited
1999
Most computational models of protein-ligand interactions consider only the energetics of the final bound state of the complex and… (More)
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Highly Cited
1993
Highly Cited
1993
Integrin Associated Protein (IAP) is a 50-kD membrane protein which copurifies with the integrin alpha v beta 3 from placenta and… (More)
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Highly Cited
1982
Highly Cited
1982
ANDRE DE LEAN, ARTHUR A. HANCOCK, AND ROBERT J. LEFKOWITZ. Validation and Statistical Analysis of a Computer Modeling Method for… (More)
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