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Ligand Binding

Ligand Binding is the tight and specific (high affinity) interaction between a small molecule (typically) and a macromolecule (usually protein) that… Expand
National Institutes of Health

Papers overview

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Review
2018
Review
2018
Reactive oxygen species (ROS) are generated within activated platelets and play an important role in regulating platelet… Expand
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Review
2018
Review
2018
The tumor necrosis factor (TNF) ligand and receptor superfamilies play an important role in cell proliferation, survival, and… Expand
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Review
2017
Review
2017
Plants have evolved a family of unique membrane receptor kinases to orchestrate the growth and development of their cells… Expand
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Highly Cited
2005
Highly Cited
2005
We developed a new computational algorithm for the accurate identification of ligand binding envelopes rather than surface… Expand
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Review
2002
Review
2002
The EGF receptor mediates many cellular responses in normal biological processes and in pathological states. Recent structural… Expand
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Highly Cited
1998
Highly Cited
1998
We recently reported the positional cloning of a candidate gene for hereditary hemochromatosis called HFE. The gene product, a… Expand
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Highly Cited
1998
Highly Cited
1998
The 2.8-A crystal structure of the complex formed by estradiol and the human estrogen receptor-alpha ligand binding domain… Expand
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Highly Cited
1997
Highly Cited
1997
Migration of cells in higher organisms is mediated by adhesion receptors, such as integrins, that link the cell to extracellular… Expand
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Review
1997
Review
1997
I. Introduction II. Biological Activities of VEGF III. Organization of the VEGF Gene IV. Properties of the VEGF Isoforms V… Expand
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Highly Cited
1988
Highly Cited
1988
A study of the binding of the antibacterial agent trimethoprim to Escherichia coli dihydrofolate reductase was carried out using… Expand
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