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Genome Sequence of Aedes aegypti, a Major Arbovirus Vector
We present a draft sequence of the genome of Aedes aegypti, the primary vector for yellow fever and dengue fever, which at ∼1376 million base pairs is about 5 times the size of the genome of theExpand
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Evolutionary Dynamics of Immune-Related Genes and Pathways in Disease-Vector Mosquitoes
Mosquitoes are vectors of parasitic and viral diseases of immense importance for public health. The acquisition of the genome sequence of the yellow fever and Dengue vector, Aedes aegypti (Aa), hasExpand
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Wolbachia induces reactive oxygen species (ROS)-dependent activation of the Toll pathway to control dengue virus in the mosquito Aedes aegypti
Wolbachia are maternally transmitted symbiotic bacteria that can spread within insect populations because of their unique ability to manipulate host reproduction. When introduced to nonnativeExpand
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Molecular characteristics of insect vitellogenins and vitellogenin receptors.
The recent cloning and sequencing of several insect vitellogenins (Vg), the major yolk protein precursor of most oviparous animals, and the mosquito Vg receptor (VgR) has brought the study of insectExpand
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Sequencing of Culex quinquefasciatus Establishes a Platform for Mosquito Comparative Genomics
Closing the Vector Circle The genome sequence of Culex quinquefasciatus offers a representative of the third major genus of mosquito disease vectors for comparative analysis. In a major internationalExpand
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Extensive Sequence Conservation Among Insect, Nematode, and Vertebrate Vitellogenins Reveals Ancient Common Ancestry
Abstract. The eggs of most oviparous animals are provisioned with a class of protein called vitellogenin (Vg) which is stored as the major component of yolk. Until recently, deduced amino acidExpand
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Accumulation of yolk proteins in insect oocytes.
In insects, accumulation of yolk, or vitellogenesis, is a heterosynthetic pro­ cess, in which an extraovarian tissue, the fat body, produces yolk protein precursors ( 1 , 92). HeterosyntheticExpand
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Efficient transformation of the yellow fever mosquito Aedes aegypti using the piggyBac transposable element vector pBac[3xP3-EGFP afm].
We report efficient germ-line transformation in the yellow fever mosquito Aedes aegypti accomplished using the piggyBac transposable element vector pBac[3xP3-EGFP afm]. Two transgenic lines wereExpand
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Molecular characterization of the mosquito vitellogenin receptor reveals unexpected high homology to the Drosophila yolk protein receptor.
The mosquito (Aedes aegypti) vitellogenin receptor (AaVgR) is a large membrane-bound protein (214 kDa when linearized) that mediates internalization of vitellogenin, the major yolk-protein precursor,Expand
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Nutritional regulation of vitellogenesis in mosquitoes: implications for anautogeny.
Anautogeny is a successful reproductive strategy utilized by many mosquito species and other disease-transmitting arthropod vectors. Developing an understanding of the mechanisms underlyingExpand
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