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Coaggregation, Cointernalization, and Codesensitization of Adenosine A2A Receptors and Dopamine D2Receptors*
TLDR
The results give a molecular basis for adenosine-dopamine antagonism at the membrane level and have implications for treatment of Parkinson's disease and schizophrenia, in which D2R are involved.
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Alternatively activated microglia and macrophages in the central nervous system
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Presynaptic Control of Striatal Glutamatergic Neurotransmission by Adenosine A1–A2A Receptor Heteromers
TLDR
It is demonstrated that heteromerization of adenosine A1 receptors and A2A receptors allowsAdenosine to exert a fine-tuning modulation of glutamatergic neurotransmission and that chronic caffeine treatment leads to modifications in the function of the A1R–A2AR heteromer that could underlie the strong tolerance to the psychomotor effects of caffeine.
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Striatal Adenosine A2A and Cannabinoid CB1 Receptors Form Functional Heteromeric Complexes that Mediate the Motor Effects of Cannabinoids
TLDR
It is reported that CB1 and adenosine A2A receptors form heteromeric complexes in co-transfected HEK-293T cells and rat striatum, where they colocalize in fibrilar structures and counteracted the motor depressant effects produced by the intrastriatal administration of a cannabinoid CB1 receptor agonist.
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Synergistic interaction between adenosine A2A and glutamate mGlu5 receptors: Implications for striatal neuronal function
TLDR
The results suggest that a functional mGluR5/A2AR interaction is required to overcome the well-known strong tonic inhibitory effect of dopamine on striatal adenosine A2AR function.
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Detection of heteromerization of more than two proteins by sequential BRET-FRET
TLDR
Using SRET, complexes of cannabinoid CB1, dopamine D2 and adenosine A2A receptors in living cells are identified and will allow us to better understand how signals are integrated at the molecular level.
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An update on adenosine A2A-dopamine D2 receptor interactions: implications for the function of G protein-coupled receptors.
TLDR
There is evidence for the coexistence of two reciprocal antagonistic interactions between A(2A) and D(2) receptors in the same neurons, the GABAergic enkephalinergic neurons, which will have implications for the pathophysiology and treatment of basal ganglia disorders and drug addiction.
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Aspects of the general biology of adenosine A2A signaling
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Cell surface adenosine deaminase: Much more than an ectoenzyme
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Comodulation of CXCR4 and CD26 in Human Lymphocytes*
TLDR
The physical association of CXCR4 and CD26, direct or part of a supramolecular structure, suggests a role on the function of the immune system and the pathophysiology of HIV infection.
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