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ACVR2A gene

Known as: ACTRII, ACTIVIN A RECEPTOR, TYPE IIA, ACVR2A 
This gene plays a role in the transforming growth factor-beta signal transduction pathway through constitutive kinase activity.
National Institutes of Health

Related topics

Related topics

8 relations
ACVR2A protein, humanACVR2A wt AlleleActivin A type II receptorLigand Binding
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Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2016
Highly Cited
2016
Activin B Induces Noncanonical SMAD1/5/8 Signaling via BMP Type I Receptors in Hepatocytes: Evidence for a Role in Hepcidin Induction by Inflammation in Male Mice.
Induction of the iron regulatory hormone hepcidin contributes to the anemia of inflammation. Bone morphogenetic protein 6 (BMP6… Expand
Highly Cited
2014
Highly Cited
2014
Treatment of sporadic inclusion body myositis with bimagrumab
Objective: To study activin signaling and its blockade in sporadic inclusion body myositis (sIBM) through translational studies… Expand
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Highly Cited
2013
Highly Cited
2013
An Antibody Blocking Activin Type II Receptors Induces Strong Skeletal Muscle Hypertrophy and Protects from Atrophy
ABSTRACT The myostatin/activin type II receptor (ActRII) pathway has been identified to be critical in regulating skeletal muscle… Expand
Highly Cited
2009
Highly Cited
2009
Biological Functions of miR-29b Contribute to Positive Regulation of Osteoblast Differentiation*
Bone tissue arises from mesenchymal cells induced into the osteoblast lineage by essential transcription factors and signaling… Expand
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Highly Cited
2008
Highly Cited
2008
Bone morphogenetic protein 6 (BMP6) and BMP7 inhibit estrogen-induced proliferation of breast cancer cells by suppressing p38 mitogen-activated protein kinase activation.
Estrogen is involved in the development and progression of breast cancer. Here, we investigated the effects of bone morphogenetic… Expand
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Highly Cited
2008
Highly Cited
2008
Cripto Is a Noncompetitive Activin Antagonist That Forms Analogous Signaling Complexes with Activin and Nodal*
Cripto plays critical roles during embryogenesis and has been implicated in promoting the growth and spread of tumors. Cripto is… Expand
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Review
2006
Review
2006
A comprehensive expression survey of bone morphogenetic proteins in breast cancer highlights the importance of BMP4 and BMP7
Bone morphogenetic proteins (BMPs) regulate diverse cellular processes, such as proliferation, differentiation, and apoptosis… Expand
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Highly Cited
2003
Highly Cited
2003
Cripto forms a complex with activin and type II activin receptors and can block activin signaling
Activin, nodal, Vg1, and growth and differentiation factor 1 are members of the transforming growth factor β superfamily and… Expand
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Highly Cited
2000
Highly Cited
2000
Betaglycan binds inhibin and can mediate functional antagonism of activin signalling
Activins and inhibins, structurally related members of the TGF-β superfamily of growth and differentiation factors, are mutually… Expand
Highly Cited
1994
Highly Cited
1994
Expression of messenger ribonucleic acids encoding the inhibin/activin system during mid- and late-gestation rat embryogenesis.
We recently demonstrated that inhibin/activin alpha-, beta A-, and beta B-subunit messenger RNAs (mRNAs) are localized in a… Expand
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