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ACVR2A gene

Known as: ACTRII, ACTIVIN A RECEPTOR, TYPE IIA, ACVR2A 
This gene plays a role in the transforming growth factor-beta signal transduction pathway through constitutive kinase activity.
National Institutes of Health

Related topics

Related topics

8 relations
ACVR2A protein, humanACVR2A wt AlleleActivin A type II receptorLigand Binding
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Papers overview

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Highly Cited
2016
Highly Cited
2016
Activin B Induces Noncanonical SMAD1/5/8 Signaling via BMP Type I Receptors in Hepatocytes: Evidence for a Role in Hepcidin Induction by Inflammation in Male Mice.
Induction of the iron regulatory hormone hepcidin contributes to the anemia of inflammation. Bone morphogenetic protein 6 (BMP6… Expand
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Highly Cited
2014
Highly Cited
2014
Treatment of sporadic inclusion body myositis with bimagrumab
Objective: To study activin signaling and its blockade in sporadic inclusion body myositis (sIBM) through translational studies… Expand
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Highly Cited
2013
Highly Cited
2013
An Antibody Blocking Activin Type II Receptors Induces Strong Skeletal Muscle Hypertrophy and Protects from Atrophy
ABSTRACT The myostatin/activin type II receptor (ActRII) pathway has been identified to be critical in regulating skeletal muscle… Expand
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Highly Cited
2009
Highly Cited
2009
Biological Functions of miR-29b Contribute to Positive Regulation of Osteoblast Differentiation*
Bone tissue arises from mesenchymal cells induced into the osteoblast lineage by essential transcription factors and signaling… Expand
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Highly Cited
2008
Highly Cited
2008
Bone morphogenetic protein 6 (BMP6) and BMP7 inhibit estrogen-induced proliferation of breast cancer cells by suppressing p38 mitogen-activated protein kinase activation.
Estrogen is involved in the development and progression of breast cancer. Here, we investigated the effects of bone morphogenetic… Expand
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Highly Cited
2008
Highly Cited
2008
Cripto Is a Noncompetitive Activin Antagonist That Forms Analogous Signaling Complexes with Activin and Nodal*
Cripto plays critical roles during embryogenesis and has been implicated in promoting the growth and spread of tumors. Cripto is… Expand
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Highly Cited
2003
Highly Cited
2003
Cripto forms a complex with activin and type II activin receptors and can block activin signaling
Activin, nodal, Vg1, and growth and differentiation factor 1 are members of the transforming growth factor β superfamily and… Expand
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Highly Cited
2002
Highly Cited
2002
Expression of activin receptors, follistatin and betaglycan by human endometrial stromal cells; consistent with a role for activins during decidualization.
Decidualization of the human endometrium is critical for implantation, but the mechanisms involved are largely unknown. Activin… Expand
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Highly Cited
2000
Highly Cited
2000
Betaglycan binds inhibin and can mediate functional antagonism of activin signalling
Activins and inhibins, structurally related members of the TGF-β superfamily of growth and differentiation factors, are mutually… Expand
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Highly Cited
1994
Highly Cited
1994
Expression of messenger ribonucleic acids encoding the inhibin/activin system during mid- and late-gestation rat embryogenesis.
We recently demonstrated that inhibin/activin alpha-, beta A-, and beta B-subunit messenger RNAs (mRNAs) are localized in a… Expand
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