ACVR2A gene

Known as: ACTRII, ACTIVIN A RECEPTOR, TYPE IIA, ACVR2A 
This gene plays a role in the transforming growth factor-beta signal transduction pathway through constitutive kinase activity.
National Institutes of Health

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8 relations
ACVR2A protein, humanACVR2A wt AlleleActivin A type II receptorLigand Binding
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Papers overview

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2015
2015
Activin A inhibits BMP-signaling by binding ACVR2A and ACVR2B
Activins are members of the TGF-β family of ligands that have multiple biological functions in embryonic stem cells as well as in… (More)
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Highly Cited
2014
Highly Cited
2014
An antibody blocking activin type II receptors induces strong skeletal muscle hypertrophy and protects from atrophy.
The myostatin/activin type II receptor (ActRII) pathway has been identified to be critical in regulating skeletal muscle size… (More)
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Highly Cited
2014
Highly Cited
2014
Treatment of sporadic inclusion body myositis with bimagrumab.
OBJECTIVE To study activin signaling and its blockade in sporadic inclusion body myositis (sIBM) through translational studies… (More)
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Highly Cited
2012
Highly Cited
2012
Sleeping Beauty mutagenesis reveals cooperating mutations and pathways in pancreatic adenocarcinoma.
Pancreatic cancer is one of the most deadly cancers affecting the Western world. Because the disease is highly metastatic and… (More)
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Highly Cited
2009
Highly Cited
2009
Biological functions of miR-29b contribute to positive regulation of osteoblast differentiation.
Bone tissue arises from mesenchymal cells induced into the osteoblast lineage by essential transcription factors and signaling… (More)
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Highly Cited
2008
Highly Cited
2008
BMP-2/4 and BMP-6/7 differentially utilize cell surface receptors to induce osteoblastic differentiation of human bone marrow-derived mesenchymal stem cells.
Bone morphogenetic proteins (BMPs) are members of the transforming growth factor-beta superfamily of growth factors and are used… (More)
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2007
2007
Proinvasive activity of BMP-7 through SMAD4/src-independent and ERK/Rac/JNK-dependent signaling pathways in colon cancer cells.
Recent data indicate that the Bone Morphogenetic Protein BMP-7 exhibits mucosal protection against experimental colitis in rats… (More)
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Highly Cited
2000
Highly Cited
2000
Betaglycan binds inhibin and can mediate functional antagonism of activin signalling
Activins and inhibins, structurally related members of the TGF-β superfamily of growth and differentiation factors, are mutually… (More)
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2000
2000
Activin A stimulates type IV collagenase (matrix metalloproteinase-2) production in mouse peritoneal macrophages.
The role of activin, a dimer of inhibin beta subunit, in mouse peritoneal macrophages was evaluated. Activin activity in the… (More)
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1995
1995
Inhibin antagonizes inhibition of liver cell growth by activin by a dominant-negative mechanism.
The beta:beta activin homodimer and alpha:beta inhibin heterodimer are mutual antagonists which share a common beta subunit… (More)
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