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Integration and evolution of the cichlid mandible: the molecular basis of alternate feeding strategies.
African cichlid fishes have repeatedly evolved highly specialized modes of feeding through adaptations of their oral jaws. Here, we explore the molecular genetic basis of the opening and closingExpand
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Tissue Engineering of Complex Tooth Structures on Biodegradable Polymer Scaffolds
Tooth loss due to periodontal disease, dental caries, trauma, or a variety of genetic disorders continues to affect most adults adversely at some time in their lives. A biological tooth substituteExpand
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Early, H+-V-ATPase-dependent proton flux is necessary for consistent left-right patterning of non-mammalian vertebrates
Biased left-right asymmetry is a fascinating and medically important phenomenon. We provide molecular genetic and physiological characterization of a novel, conserved, early, biophysical event thatExpand
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Bioengineered Teeth from Cultured Rat Tooth Bud Cells
The recent bioengineering of complex tooth structures from pig tooth bud tissues suggests the potential for the regeneration of mammalian dental tissues. We have improved tooth bioengineering methodsExpand
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The pro‐apoptotic kinase Mst1 and its caspase cleavage products are direct inhibitors of Akt1
Akt kinases mediate cell growth and survival. Here, we report that a pro‐apoptotic kinase, Mst1/STK4, is a physiological Akt1 interaction partner. Mst1 was identified as a component of an Akt1Expand
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Bioengineered Dental Tissues Grown in the Rat Jaw
Our long-term objective is to develop methods to form, in the jaw, bioengineered replacement teeth that exhibit physical properties and functions similar to those of natural teeth. Our results showExpand
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Molecular pedomorphism underlies craniofacial skeletal evolution in Antarctic notothenioid fishes
BackgroundPedomorphism is the retention of ancestrally juvenile traits by adults in a descendant taxon. Despite its importance for evolutionary change, there are few examples of a molecular basis forExpand
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Functional characterization and genetic mapping of alk8
The novel type I TGFbeta family member receptor alk8 is expressed both maternally and zygotically. Functional characterization of alk8 was performed using microinjection studies of constitutivelyExpand
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Molecular dissection of craniofacial development using zebrafish.
The zebrafish, Danio rerio, is a small, freshwater teleost that only began to be used as a vertebrate genetic model by the late George Streisinger in the early 1980s. The strengths of the zebrafishExpand
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Ribosomopathies: Global process, tissue specific defects
Disruptions in ribosomal biogenesis would be expected to have global and in fact lethal effects on a developing organism. However, mutations in ribosomal protein genes have been shown in to exhibitExpand
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