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In recent years, a significant amount of research has examined the controversial role of activin A in cancer. Activin A, a member… Expand Objective: To study activin signaling and its blockade in sporadic inclusion body myositis (sIBM) through translational studies… Expand ABSTRACT The myostatin/activin type II receptor (ActRII) pathway has been identified to be critical in regulating skeletal muscle… Expand Myostatin is a secreted TGF-beta family member that controls skeletal muscle growth. Humans, cattle, and dogs carrying natural… Expand Activins and inhibins, structurally related members of the TGF-β superfamily of growth and differentiation factors, are mutually… Expand Type II activin receptors (ActRII and ActRIIB) are single-transmembrane domain serine/threonine kinase receptors that bind… Expand The transforming growth factor β (TGFβ) superfamily of cytokines elicit diverse biological responses by interacting with two… Expand Activins and inhibins belong to the transforming growth factor beta (TGF-beta)-like superfamily and exert their effects on a… Expand The β:β activin homodimer and α:β inhibin heterodimer are mutual antagonists which share a common β subunit. Recently, it has… Expand We have studied the distribution of activin receptor gene expression in the brain, pituitary, ovary, and testis of the adult rat… Expand