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ACVR2A protein, human

Known as: ACTRIIA, Activin Receptor Type IIA, ACTR-II 
Activin receptor type-2A (513 aa, ~58 kDa) is encoded by the human ACVR2A gene. This protein is involved in signal transduction and embryonic… Expand
National Institutes of Health

Related topics

Related topics

15 relations
ACVR2A geneEnzyme GeneHomo sapiensLigand Binding
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Broader (2)

Activin A type II receptorReceptor Serine/Threonine Kinase

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2012
Highly Cited
2012
Specificity and Structure of a High Affinity Activin Receptor-like Kinase 1 (ALK1) Signaling Complex
Background: Activin receptor-like kinase 1 (ALK1) is an important regulator of normal blood vessel formation and pathological… Expand
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Highly Cited
2009
Highly Cited
2009
Single-dose, randomized, double-blind, placebo-controlled study of ACE-011 (ActRIIA-IgG1) in postmenopausal women.
The effects of ACE-011 on safety, pharmacokinetics, and bone biomarkers were evaluated in healthy, postmenopausal women. Our data… Expand
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Highly Cited
2008
Highly Cited
2008
Hemojuvelin regulates hepcidin expression via a selective subset of BMP ligands and receptors independently of neogenin.
Hemojuvelin (HJV) is a coreceptor for bone morphogenetic protein (BMP) signaling that regulates hepcidin expression and iron… Expand
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Highly Cited
2008
Highly Cited
2008
A soluble activin Type IIA receptor induces bone formation and improves skeletal integrity
Diseases that affect the regulation of bone turnover can lead to skeletal fragility and increased fracture risk. Members of the… Expand
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Highly Cited
2007
Highly Cited
2007
Identification of BMP9 and BMP10 as functional activators of the orphan activin receptor-like kinase 1 (ALK1) in endothelial cells.
ALK1 is an endothelial-specific type I receptor of the TGFbeta receptor family whose heterozygous mutations cause hereditary… Expand
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Highly Cited
2007
Highly Cited
2007
Distinct and cooperative roles of mammalian Vg1 homologs GDF1 and GDF3 during early embryonic development.
Vg1, a member of the TGF-beta superfamily of ligands, has been implicated in the induction of mesoderm, formation of primitive… Expand
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Highly Cited
2005
Highly Cited
2005
Bone Morphogenetic Protein (BMP) Type II Receptor Deletion Reveals BMP Ligand-specific Gain of Signaling in Pulmonary Artery Smooth Muscle Cells*
Bone morphogenetic protein (BMP) ligands signal by binding the BMP type II receptor (BMPR2) or the activin type II receptors… Expand
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Highly Cited
2002
Highly Cited
2002
Inhibition of Nodal signalling by Lefty mediated through interaction with common receptors and efficient diffusion.
BACKGROUND Two TGFbeta-related proteins, Nodal and Lefty, are implicated in early embryonic patterning of vertebrates. Genetic… Expand
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Highly Cited
2000
Highly Cited
2000
Activin receptor patterning of foregut organogenesis.
Foregut development produces a characteristic sequence of gastrointestinal and respiratory organs, but the signaling pathways… Expand
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Highly Cited
1998
Highly Cited
1998
Characterization of inhibin/activin subunit, activin receptor, and follistatin messenger ribonucleic acid in human and mouse oocytes: evidence for activin's paracrine signaling from granulosa cells…
Inhibin, activin, and follistatin (FS) are gonadal proteins that appear to have a role in regulating folliculogenesis through… Expand
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