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Sequence and Characterization of a Coactivator for the Steroid Hormone Receptor Superfamily
A yeast two-hybrid system was used to identify a protein that interacts with and enhances the human progesterone receptor (hPR) transcriptional activity without altering the basal activity of theExpand
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A Steroid Receptor Coactivator, SRA, Functions as an RNA and Is Present in an SRC-1 Complex
Nuclear receptors play critical roles in the regulation of eukaryotic gene expression. We report the isolation and functional characterization of a novel transcriptional coactivator, termed steroidExpand
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Steroid receptor coactivator-1 is a histone acetyltransferase
Steroid receptors and coactivator proteins are thought to stimulate gene expression by facilitating the assembly of basal transcription factors into a stable preinitiation complex. What is not clear,Expand
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Partial hormone resistance in mice with disruption of the steroid receptor coactivator-1 (SRC-1) gene.
The in vivo biological function of a steroid receptor coactivator was assessed in mice in which the SRC-1 gene was inactivated by gene targeting. Although in both sexes the homozygous mutants wereExpand
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Chick ovalbumin upstream promoter-transcription factors (COUP-TFs): coming of age.
I. Introduction II. The COUP-TF Gene Family A. Homology to other members of the steroid/thyroid hormone receptor superfamily B. Sequence homology within the COUP-TF gene family III. BiochemicalExpand
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Chicken ovalbumin upstream promoter transcription factor (COUP-TF) dimers bind to different GGTCA response elements, allowing COUP-TF to repress hormonal induction of the vitamin D3, thyroid hormone,
Alignment of natural chicken ovalbumin upstream promoter transcription factor (COUP-TF) response elements shows that, in addition to the predominant direct repeat of the GGTCA motif with a 2-bpExpand
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Selective phosphorylations of the SRC-3/AIB1 coactivator integrate genomic reponses to multiple cellular signaling pathways.
Although several lines of evidence have indicated that the activity of SRC-3/AIB1/ACTR/pCIP/RAC3/TRAM1 could be regulated by phosphorylation, an important question remained as to how differentExpand
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A regulatory system for use in gene transfer.
We recently have demonstrated that a C-terminal deletion mutant of the human progesterone receptor (hPRB891) fails to bind to progesterone but can bind RU 486 (Mifepristone) and other progesteroneExpand
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The tau 4 activation domain of the thyroid hormone receptor is required for release of a putative corepressor(s) necessary for transcriptional silencing.
The C terminus of nuclear hormone receptors is a complex structure that contains multiple functions. We are interested in the mechanism by which thyroid hormone converts its receptor from aExpand
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Bmp2 Is Critical for the Murine Uterine Decidual Response
ABSTRACT The process of implantation, necessary for all viviparous birth, consists of tightly regulated events, including apposition of the blastocyst, attachment to the uterine lumen, andExpand
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