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Sequence and Characterization of a Coactivator for the Steroid Hormone Receptor Superfamily
TLDR
Results indicate that SRC-1 encodes a coactivator that is required for full transcriptional activity of the steroid receptor superfamily. Expand
A Steroid Receptor Coactivator, SRA, Functions as an RNA and Is Present in an SRC-1 Complex
TLDR
Functional and mechanistic evidence is provided that SRA acts as an RNA transcript; transfected SRA, unlike other steroid receptor coregulators, functions in the presence of cycloheximide, and SRA mutants containing multiple translational stop signals retain their ability to activate steroid receptor-dependent gene expression. Expand
Steroid receptor coactivator-1 is a histone acetyltransferase
TLDR
It is shown that SRC-1 possesses intrinsic histone acetyltransferase activity and that it also interacts with another HAT, p300/CBP-associated factor (PCAF), which could be a mechanism by which the activation functions of steroid receptors and associated coactivators enhance formation of a stable preinitiation complex, thereby increasing transcription of specific genes from transcriptionally repressed chromatin templates. Expand
Suppression of Notch signalling by the COUP-TFII transcription factor regulates vein identity
TLDR
It is shown that COUP-TFII has a critical role in repressing Notch signalling to maintain vein identity, which suggests that vein identity is under genetic control and is not derived by a default pathway. Expand
Partial hormone resistance in mice with disruption of the steroid receptor coactivator-1 (SRC-1) gene.
TLDR
The results indicate that SRC-1 mediates steroid hormone responses in vivo and that loss of its coactivator function results in partial resistance to hormone. Expand
Lineage tracing demonstrates the venous origin of the mammalian lymphatic vasculature.
TLDR
From venous-derived lymph sacs, lymphatic endothelial cells sprouted, proliferated, and migrated to give rise to the entire lymphatic vasculature, and that hematopoietic cells did not contribute to the developing lymph sacS. Expand
Interaction of human thyroid hormone receptor beta with transcription factor TFIIB may mediate target gene derepression and activation by thyroid hormone.
TLDR
The data suggest that hTR beta acts as a transcriptional silencer by interacting with TFIIB and that thyroid hormone may act in part by preventing transcriptional repression at this level. Expand
Chick ovalbumin upstream promoter-transcription factors (COUP-TFs): coming of age.
TLDR
This work has shown that COUP-TFs acts as a “spatially aggregating force” to reprogram other members of the steroid/thyroid hormone receptor superfamily into a single gene family. Expand
Chicken ovalbumin upstream promoter transcription factor (COUP-TF) dimers bind to different GGTCA response elements, allowing COUP-TF to repress hormonal induction of the vitamin D3, thyroid hormone,
TLDR
A functional consequence of the promiscuous DNA binding of COUP-TF is its ability to down-regulate hormonal induction of target gene expression by other members of the steroid-thyroid hormone receptor superfamily such as the vitamin D3, thyroid hormone, and retinoic acid receptors. Expand
Selective phosphorylations of the SRC-3/AIB1 coactivator integrate genomic reponses to multiple cellular signaling pathways.
TLDR
The results uncovered an additional level of transcriptional regulation whereby specific modulations of SRC-3 phosphorylation allow this coactivator to function as a regulatable integrator for diverse signaling pathways in cells. Expand
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